Postoperative Atrial Fibrillation in Cardiac Surgery (POAF)
Incidence and Risk Factors of Postoperative Atrial Fibrillation in Cardiac Surgery Patients
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, with incidence rates reported between 15-30% after valve surgery and 18-74% after coronary artery bypass grafting. POAF typically occurs within 72 hours after surgery and is associated with increased morbidity, mortality, length of hospital stay, and healthcare costs.
The Society of Thoracic Surgeons has identified five major postoperative complications associated with cardiac surgery, including POAF, which can significantly affect patient outcomes. This multicenter observational study will examine the incidence and risk factors of POAF in cardiac surgery patients across three medical centers in Thailand: Srinagarind Hospital at Khon Kaen University, Northeastern Thailand Cardiac Center, and Surat Thani Hospital.
The study will collect data on patient demographics, comorbidities, preoperative laboratory values, perioperative characteristics, surgical procedures (valve surgery, CABG, combined procedures), and postoperative complications. By identifying risk factors associated with POAF, this study aims to develop preventive strategies and improve management protocols for patients at high risk for this complication.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Sirirat Tribuddharat, MD, PhD
- Phone Number: 66-81-6205921
- Email: sirirat.tribuddharat@gmail.com
Study Locations
-
-
-
Khon Kaen, Thailand, 40002
- Recruiting
- Faculty of Medicine, Khon Kaen University
-
Contact:
- Thepakorn Sathitkarnmanee, MD
- Phone Number: +66819547622
- Email: thepakorns@gmail.com
-
Principal Investigator:
- Sirirat Tribuddharat, MD, PhD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Age ≥ 18 years
- Patients undergoing cardiac valve surgery or coronary artery bypass grafting (CABG) procedures
Exclusion Criteria:
- Patients undergoing aortic surgery
- Patients undergoing MAZE procedure
- Incomplete medical records
- Patients who required mechanical circulatory support before surgery
- Patients who died during surgery or within 3 days after surgery
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Cardiac surgery
Patients undergoing cardiac surgery
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Patients receiving general anesthesia for cardiac surgery
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Incidence
Time Frame: 72 hours postoperatively
|
The incidence of POAF
|
72 hours postoperatively
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Risk factors
Time Frame: 72 hours postoperatively
|
Risk factors associated with POAF
|
72 hours postoperatively
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Thepakorn Sathitkarnmanee, MD, Khon Kaen University
Publications and helpful links
General Publications
- Echahidi N, Pibarot P, O'Hara G, Mathieu P. Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery. J Am Coll Cardiol. 2008 Feb 26;51(8):793-801. doi: 10.1016/j.jacc.2007.10.043.
- Lopes LA, Agrawal DK. Post-Operative Atrial Fibrillation: Current Treatments and Etiologies for a Persistent Surgical Complication. J Surg Res (Houst). 2022;5(1):159-172. doi: 10.26502/jsr.10020209. Epub 2022 Mar 28.
- Crawford TC, Magruder JT, Grimm JC, Suarez-Pierre A, Sciortino CM, Mandal K, Zehr KJ, Conte JV, Higgins RS, Cameron DE, Whitman GJ. Complications After Cardiac Operations: All Are Not Created Equal. Ann Thorac Surg. 2017 Jan;103(1):32-40. doi: 10.1016/j.athoracsur.2016.10.022. Epub 2016 Nov 22.
- Gudbjartsson T, Helgadottir S, Sigurdsson MI, Taha A, Jeppsson A, Christensen TD, Riber LPS. New-onset postoperative atrial fibrillation after heart surgery. Acta Anaesthesiol Scand. 2020 Feb;64(2):145-155. doi: 10.1111/aas.13507. Epub 2019 Dec 2.
- Melduni RM, Koshino Y, Shen WK. Management of arrhythmias in the perioperative setting. Clin Geriatr Med. 2012 Nov;28(4):729-43. doi: 10.1016/j.cger.2012.08.006.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HE671492
- Khon Kaen University (Other Identifier: Khon Kaen University)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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