Comparing Two Eccentric Protocols on Muscle Damage

A Novel Eccentric Resistance Training Strategy to Maximize Exercise Induced Muscle Damage in Young Adults

The purpose of this study will be to test whether a new way of weight training is more effective than typical weight training. The investigators expect that this new way will cause more exercise-induced muscle damage, which helps people build bigger muscles. Another purpose of this study will be to explore perceptions of how muscle soreness impacts participant activities of daily living.

Study Overview

• Status: Recruiting
• Conditions: Muscle Damage; Eccentric Hypertrophy
• Intervention / Treatment: Behavioral: Fast Eccentric; Behavioral: Slow Eccentric

Detailed Description

Participants will come to the lab for 3 sessions, plus two email follow-up questionnaires.

Session 1 (45 minutes)

• Complete a demographic questionnaire
• Self-assess muscle soreness
• Walk on the treadmill to warm-up
• Maximal voluntary contraction on the chest press
• Two sets of eccentric (lowering) bench press at 75% of max

Session 2 (45 minutes)

• Walk on the treadmill to warm up
• Maximal voluntary contraction on the chest press
• Three sets of 10 eccentric contractions at 75% of max
• Repeat the maximal voluntary contraction on the chest press

Session 2 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

Session 3 (45 minutes) Walk on the treadmill to warm up Maximal voluntary contraction on the chest press Three sets of 10 eccentric contractions at 75% of max Repeat the maximal voluntary contraction on the chest press

Session 3 Follow-up Rate muscle soreness for each of the three days following Session 2 Answer open-ended questions about perceptions of the muscle soreness

• Study Type: Interventional
• Enrollment (Estimated): 16
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Amerigo Rossi, Ed.D; Phone Number: 516 686-3884; Email: arossi01@nyit.edu

Study Locations

• United States
  • New York
    • Old Westbury, New York, United States, 11568
      • Recruiting
      • NYIT
      • Contact: Amerigo Rossi, EdD; Phone Number: 516-686-3884; Email: arossi01@nyit.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Sixteen young adults (ages 18-35) will be enrolled in this study.
• In order to be enrolled, they must have completed at least three months of resistance training in the past five years in order to minimize the learning effect and chance of injury.

Exclusion Criteria:

• Since regular resistance training reduces the primary outcomes, muscle damage and soreness, individuals who currently participate in chest press resistance training at least once per week will be excluded.
• Individuals who have musculoskeletal injuries in the shoulder, elbow or wrist that preclude pain-free resistance training, or who have underlying uncontrolled cardiovascular complications will also be excluded.
• Women who are pregnant, or may consider becoming pregnant over the subsequent 2 months, will be excluded

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Fast Eccentric; Participants will perform fast eccentric resistance training	Behavioral: Fast Eccentric; Resistance training done quickly
Active Comparator: Slow eccentric; Participants will perform slow eccentric resistance training	Behavioral: Slow Eccentric; Resistance training done slowly

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle soreness 1	Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness	1 day
Muscle soreness 2	Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness	2 days
Muscle soreness 3	Visual analog scale as indirect indicator of muscle damage. Scale of 1-5. Higher score = more soreness	3 days
Maximal Voluntary Isometric Contraction Change	Change in MVIC will be used to indicated muscle damage.	pre-intervention, immediately after the intervention

Collaborators and Investigators

• Sponsor: New York Institute of Technology
• Investigators: Principal Investigator: Amerigo Rossi, Ed.D, New York Institute of Technology

Study record dates

Study Major Dates

• Study Start (Actual): March 8, 2023
• Primary Completion (Estimated): June 1, 2025
• Study Completion (Estimated): June 1, 2025

Study Registration Dates

• First Submitted: March 9, 2023
• First Submitted That Met QC Criteria: May 19, 2025
• First Posted (Actual): May 28, 2025

Study Record Updates

• Last Update Posted (Actual): May 28, 2025
• Last Update Submitted That Met QC Criteria: May 19, 2025
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathological Conditions, Anatomical; Hypertrophy
• Other Study ID Numbers: BHS-1835

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No