Cannabis Use Patterns Among Young Adults and Associations With Social and Health Outcomes. (TRICCHOME)

Trajectoires Individuelles de Consommation de Cannabis en Situation Habituelle et Observations de Leurs Modalités en Contexte Écologique

The purpose of this study is to identify and characterize patterns of non-therapeutic cannabis consumption and their variation in time in regular/daily users aged 18-24 years using a multi-factor approach (frequency of use, product types, cannabinoid dosages) over a two-year period.

Study Overview

• Status: Recruiting
• Conditions: Cannabis Use
• Intervention / Treatment: Other: Mobile application

Detailed Description

Changes in the legal status of cannabis in Canada have highlighted the need for knowledge about the substance and its effects at individual, population and societal levels. In Quebec, in the past year, one in four cannabis users reported weekly use, and around 15% reported daily use. More specifically, young people between the ages of 18 and 24 account for the largest proportion of this consumption, representing a large proportion of these regular to daily users. Little information is currently available about the correlates, evolution and effects of regular, daily cannabis use in this age group, despite the fact that it is the most widely used in the province.

Such comprehensive longitudinal data on consumption dynamics within this population is crucial for our understanding of whether and how cannabis use trajectories vary over time, characterizing the health and social consequences of cannabis consumption at this critical stage in human development, and ultimately providing evidence for the development of strategies to prevent and mitigate potential harms to this specific population.

• Study Type: Observational
• Enrollment (Estimated): 350

Contacts and Locations

• Study Contact: Name: Pamela Lachance-Touchette, Ph.D.; Phone Number: 30938 514-890-8000; Email: pamela.lachance-touchette.chum@ssss.gouv.qc.ca
• Study Contact Backup: Name: François-Olivier Hébert, Ph.D.; Email: francois-olivier.hebert.chum@ssss.gouv.qc.ca

Study Locations

• Canada
  • Quebec
    • Montreal, Quebec, Canada, H2X0A9
      • Recruiting
      • Centre de recherche du Centre Hospitalier Universitaire de Montréal
      • Contact: Pamela Lachance-Touchette, Ph.D; Phone Number: 514 995 5338; Email: pamela.lachance-touchette.chum@ssss.gouv.qc.ca
      • Principal Investigator: Didier Jutras-Aswad, MD
      • Contact: Isabelle Boisvert, Ba.; Phone Number: 30411 514 890 8000; Email: isabelle.boisvert.ib.chum@ssss.gouv.qc.ca

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The target population for TRICCHOME is young adults between 18 and 24 years of age, who use cannabis regularly or daily.

Description

Inclusion Criteria:

• 18 to 24 years of age;
• Cannabis use frequency of at least 1 day/week in the past three months;
• Ability to speak and read French or English;
• willingness to comply with all study procedures;
• access to a mobile phone.

Exclusion Criteria:

• Planned extended absence during study period (e.g. pending legal action, surgery, incarceration, inpatient residential program) which, in the opinion of the research staff, might prevent completion of the study;
• Current or anticipated treatment for cannabis use disorder, confirmed via self-report;
• Medical document authorizing the use of cannabis for medical purposes;
• Participation in clinical studies or undergoing other investigational procedures involving cannabis or cannabinoids administration.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cannabis use patterns	Primary outcome measures of this study are specific assessments of cannabis use patterns, measured at baseline and daily using the mobile app. Primary outcome assessments related to cannabis use patterns will be tracked daily, taking advantage of a short but detailed series of questions taking approximately 1-5 minutes to answer, depending on the number of consumption events during the day. Participants will be advised to provide information even during non-consumption days, which in these cases will be limited to their general appreciation of the day, in addition to the fact that they did not consume that day. Participants will be able to retrospectively enter daily cannabis consumption data up to a maximum of seven days in the past, to minimize recall bias.	Baseline
Trajectories of consumption patterns over time_Route of administration	The investigators will use weekly reports on participants' habits surrounding cannabis use in the form of logbook entries, covering the route of administration for each product. This information will be collected for each consumption session during a use day.	From baseline (Day 1) up to two year (Day 730)
Trajectories of consumption patterns over time_product type	The investigators will use weekly reports on participants' habits surrounding cannabis use in the form of logbook entries, covering the product type for each product. This information will be collected for each consumption session during a use day.	From baseline (Day 1) up to two year (Day 730)
Trajectories of consumption patterns over time_THC constituent (%)	The investigators will use weekly reports on participants' habits surrounding cannabis use in the form of logbook entries, covering the THC constituent (%) for each product. This information will be collected for each consumption session during a use day.	From baseline (Day 1) up to two year (Day 730)
Trajectories of consumption patterns over time_CBD constituent (%)	The investigators will use weekly reports on participants' habits surrounding cannabis use in the form of logbook entries, covering the CBD constituent (%) for each product. This information will be collected for each consumption session during a use day.	From baseline (Day 1) up to two year (Day 730)
Trajectories of consumption patterns over time_amount per use	The investigators will use weekly reports on participants' habits surrounding cannabis use in the form of logbook entries, covering the amount per use for each product. This information will be collected for each consumption session during a use day.	From baseline (Day 1) up to two year (Day 730)
Trajectories of consumption patterns over time_supply source	The investigators will also capture information on supply source (choices are: cultivated by me or for me, family member or friend or acquaintance, SQDC, legal source from another province, health Canada licensed producer, illegal market) for each product used in the logbook.	From baseline (Day 1) up to two year (Day 730)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Socio-demographic and behavioral determinants	In addition to the information contained in the weekly logbook entries, for each cannabis use event we will collect socio-demographic variables to identify patterns of cannabis consumption. Based on this multi-factor approach, we hypothesize that users will fall into distinct clusters of consumption patterns (e.g., stable, chaotic/variable patterns, etc.), which will each be associated with specific psychosocial determinants and health outcomes.	From baseline (Day 1) up to two year (Day 730) and from week 1 to week 104 and every 4 months (Weeks16, 32, 48, 64, 96)
Socio-demographic and behavioral determinants	In addition to the information contained in the weekly logbook entries, for each cannabis use event and every four months, various social and health measures will be collected with the mobile application. Based on this multi-factor approach, we hypothesize that users will fall into distinct clusters of consumption patterns (e.g., stable, chaotic/variable patterns, etc.), which will each be associated with specific psychosocial determinants and health outcomes.	At Weeks 16, 32, 48, 64 and 96

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Association between variations in cannabis use patterns and health-related and social outcomes.	The following health-related outcomes will be measured at baseline and at 4-month intervals using the mobile app for a total of nine times. Genetic profiles of participant will be used to perform genotype to phenotype associations based on health-related outcomes. Participants will be genotyped at more than 700,000 genome-wide loci to determine if specific genetic variants are significantly associated with some of the patterns of use detected in objective 1. Associations between genetic variants and health-related outcomes will additionally be tested to identify potential genetic vulnerabilities to higher risks of experiencing health problems.	baseline, Weeks 16, 32, 48, 64 and 96

Collaborators and Investigators

• Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
• Investigators: Principal Investigator: Didier Jutras-Aswad, MD, MS, CRCHUM

Study record dates

Study Major Dates

• Study Start (Actual): September 16, 2025
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 1, 2027

Study Registration Dates

• First Submitted: May 12, 2025
• First Submitted That Met QC Criteria: July 2, 2025
• First Posted (Actual): July 14, 2025

Study Record Updates

• Last Update Posted (Actual): December 24, 2025
• Last Update Submitted That Met QC Criteria: December 18, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Marijuana Abuse
• Other Study ID Numbers: 2025-12297

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No