Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up

November 17, 2025 updated by: Furkan Salih Bilgi, Medipol University
The objective of this research was to identify which of the root canal sealers, AH Plus or WellRootST, yielded more effective outcomes regarding postoperative pain when applied to teeth diagnosed with apical periodontitis.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

A prospective cohort study was conducted at a single center, involving 120 patients diagnosed with chronic apical periodontitis (AP) admitted for endodontic treatment. Patients were categorized into two groups based on the type of root canal sealer used. Sixty patients treated with AH Plus sealer constituted Group 1, while sixty patients treated with WellRootST sealer comprised Group 2. Data collected for all participants included age, gender, findings from oral and dental examinations, tooth type, tooth number, duration of root canal treatment, and Visual Analog Scale (VAS) results recorded preoperatively, as well as at 24 hours, 48 hours, 72 hours, 1 week, and 1 month postoperatively.

Study Type

Interventional

Enrollment (Actual)

120

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

The inclusion criteria for this study were as follows:

  1. Participants had to be at least 18 years old
  2. One mature tooth showing signs or symptoms that required primary root canal treatment.
  3. Participants needed to be in good general health
  4. classified as ASA I or II, and able to follow the follow-up schedule.

Exclusion criteria criteria for this study were as follows:

  1. Included teeth with internal or external root resorption,
  2. Signs of perforation
  3. The need for post-core application, or previous restoration with fixed prosthetic appliances, such as crowns or bridges

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: AhPlus sealer
AH Plus sealer used
Procedure: AH-Plus Epoxy Resin Sealer
AhPlus sealer was used for group 1
Experimental: WellRootST sealer
WellRootST sealer used
Procedure: bioceramic sealer
WellRootSt wa used for group 2

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
postoperative pain evaluation by VAS scale
Time Frame: Baseline, 24 hour postoperatively, 48hour postoperatively, 72 hour postoperatively, Day 3 and Day 7
Study groups were compared in terms of VAS scores at the preoperative period and postoperative 24 hours, 48 hours, 72 hours, 1 week, and 1 month
Baseline, 24 hour postoperatively, 48hour postoperatively, 72 hour postoperatively, Day 3 and Day 7

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Medipol University

Investigators

  • Principal Investigator: Furkan S Bilgi, PhD, Medipol University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2024

Primary Completion (Actual)

November 1, 2024

Study Completion (Actual)

December 31, 2024

Study Registration Dates

First Submitted

November 14, 2025

First Submitted That Met QC Criteria

November 17, 2025

First Posted (Actual)

November 24, 2025

Study Record Updates

Last Update Posted (Actual)

November 24, 2025

Last Update Submitted That Met QC Criteria

November 17, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • E-10840098-772.02-243

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Upon request from the authors with a reasonable request, our data will be made open

IPD Sharing Time Frame

After the acceptance of our study

IPD Sharing Access Criteria

Our data will be shared via email

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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