BPIT 5-Week Multi-Site Study: Movement Efficiency, Mobility & Neuromuscular Adaptation (BPIT_5LINE_369)

December 8, 2025 updated by: MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.

Balanced Progressive Intensity Training (BPIT): A Five-Week Multi-Site Clinical Evaluation of Functional Movement, Mobility, and Neuromuscular Adaptation in Healthy Adults (18-65 Years)

This prospective, multi-site, single-arm interventional study evaluates the 5-Line Principle of Balanced Progressive Intensity Training (BPIT) over 5 weeks in healthy adults aged 18-65 years. All participants receive supervised BPIT sessions (3-5 per week) progressing through five intensity lines defined by anatomical landmarks and ground reaction force:

Ground-Based (Low) Knee-Level (Low-Moderate) Standing (Moderate) Head-Level (Moderate-High) Plyometric (High-Impact)

The study aims to quantify improvements in functional movement efficiency, joint mobility, postural control, strength adaptation, and heart-rate variability while monitoring safety and individual overload indicators.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Primary Outcome Measures

Change in Functional Movement Screen (FMS) total score from baseline to Week 5 Change in Y-Balance Test reach distance (composite score) Timeframe: Baseline and Week 5

Secondary Outcome Measures

Change in 1-RM or estimated strength (squat, deadlift, overhead press) Change in resting HRV (RMSSD) Change in joint range of motion (goniometry) and postural sway Incidence of training-related discomfort or minor injury Timeframe: Baseline, weekly, and Week 5

Arms/Intervention Experimental: BPIT 5-Line Training Group Intervention: Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method Description: 5-week supervised progressive training using the BPIT 5-Line framework (ground-based → plyometric) Eligibility

Ages Eligible: 18 Years to 65 Years Sexes Eligible: All Accepts Healthy Volunteers: Yes

Inclusion Criteria

Healthy adults with regular exercise history Able to attend 3-5 training sessions/week Signed informed consent

Exclusion Criteria

Recent injury (<3 months) Known cardiovascular, metabolic, or orthopaedic contraindications Pregnancy

Study Locations 13 Locations in India 2 Locations in USA, (Details of the location is uploaded on mmsxauthority.com webiste)

MMSx Authority , USA, GFFI Fitness Academy, New Delhi BodyGNTX USA BFS/AIHFT-approved facilities

Countries of Recruitment India U.S. FDA-regulated? No / No / No Human Subjects Protection Review Board Status Approved (or Submit for review if not yet) Board Name: Institutional Ethics Committee - MMSx Authority / GFFI Approval Number: BPIT-MULTI-2025-001 (or pending) Data Monitoring Committee No

Study Type

Interventional

Enrollment (Estimated)

369

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • India
    • Madhya Pradesh
      • Burhānpur, Madhya Pradesh, India, 450331
        • Recruiting
        • Indian Institute of Kinesiology & Biomechanics Science (IIKBS)
        • Contact:
          • Dr. Anya Petrova, M.D., Ph.D. (Sports Med)
          • Phone Number: +919990744422
          • Email: info@iikbs.org
        • Contact:
          • Laura Green, R.N.
          • Phone Number: +91-9990744422
          • Email: info@iikbs.org
        • Sub-Investigator:
          • Pankaj Mehta, MSc
    • National Capital Territory of Delhi
      • Delhi, National Capital Territory of Delhi, India, 110032
        • Recruiting
        • Shri Mahaveer Ortho Clinic
        • Contact:
          • Dr Karun Jain, MBBS, D'Ortho, MS Ortho
          • Phone Number: +91-8285257076
          • Email: karunjain@live.com
        • Contact:
          • Karun Jain, MBBS
        • Sub-Investigator:
          • Sumit Chaudhary, MMSx Pro, CPT,
      • New Delhi, National Capital Territory of Delhi, India, 110026
        • Recruiting
        • GFFI Fitness Academy
        • Contact:
        • Contact:
        • Principal Investigator:
          • Pankaj Mehta, M.P.Ed.
      • New Delhi, National Capital Territory of Delhi, India, 110063
        • Recruiting
        • Active India Health & Fitness Trust (AIHFT)
        • Sub-Investigator:
          • Pankaj Mehta, MSc
        • Contact:
        • Contact:
      • New Delhi, National Capital Territory of Delhi, India, 110092
        • Recruiting
        • Body Mechanics Gym P Ltd
        • Contact:
        • Contact:
        • Sub-Investigator:
          • Pankaj Mehta, M.P.Ed.
    • Uttar Pardesh
      • Greater Noida, Uttar Pardesh, India, 201310
        • Recruiting
        • Regain Fitness Zone
        • Sub-Investigator:
          • Sumit Chaudhary, MMSx Pro, CPT,
        • Sub-Investigator:
          • Pankaj Mehta, M.P.Ed.
        • Contact:
        • Contact:
    • Uttar Pradesh
      • Agra, Uttar Pradesh, India, 282005
  • United States
    • Ohio
      • Columbus, Ohio, United States, 43220
        • Recruiting
        • BodyGNTX Fitness Institute
        • Contact:
        • Contact:
        • Principal Investigator:
          • Neeraj Mehta, PhD
      • Powell, Ohio, United States, 43065
        • Recruiting
        • MMSx Authority Biomechanics Department
        • Contact:
        • Contact:
          • Sunita Malhotra, GCP
          • Phone Number: 6144776065
      • Powell, Ohio, United States, 43065
        • Recruiting
        • MMSx AUTHORITY INSTITUTE FOR MOVEMENT MECHANICS & BIOMECHANICS RESEARCH (COORDINATING CENTER)
        • Contact:
        • Principal Investigator:
          • Neeraj Mehta, PhD
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Adults aged 18-65 years Generally healthy with regular physical activity history (at least 1-2 sessions per week for the past 3 months) Able to commit to 3-5 supervised training sessions per week for 5 weeks Willing and able to provide written informed consent Cleared by pre-screening (no acute injury, no contraindications)

Exclusion Criteria:

  • Acute musculoskeletal injury within the past 3 months Known cardiovascular, metabolic, or orthopaedic conditions that contraindicate exercise Pregnancy or planning pregnancy Use of medications or supplements that significantly affect muscle recovery or performance (e.g., corticosteroids, anabolic agents) Inability to follow the BPIT protocol or attend required sessions

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: BPIT 5-Line Training Group
All participants receive the 5-week Balanced Progressive Intensity Training (BPIT) program using the 5-Line Principle (ground-based → knee-level → standing → head-level → plyometric) under supervised sessions 3-5 times per week.
Behavioral: Balanced Progressive Intensity Training (BPIT) 5-Line Method
5-week supervised progressive training using the BPIT 5-Line framework developed by Dr. Neeraj Mehta.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Movement Efficiency Score (MES, 0-10)
Time Frame: Baseline (Week 0) and end of study (Week 5)
Change from baseline in the proprietary Movement Efficiency Score (MES), a validated composite metric of biomechanical function, movement quality, and postural alignment (derived from MMSx Flaw Checklist, visual/video analysis, and functional mapping).
Baseline (Week 0) and end of study (Week 5)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Range of Motion (ROM)
Time Frame: Baseline and Week 5
Change from baseline in joint range of motion (degrees) measured by goniometry at key sites (shoulder, hip, spine, ankle).
Baseline and Week 5
VAS Pain Score
Time Frame: Baseline and Week 5
Change from baseline in participant-reported pain/discomfort on a 0-10 Visual Analog Scale.
Baseline and Week 5
Strength Index
Time Frame: Baseline and Week 5
Change from baseline in Strength Index calculated as Reps × Load (or estimated 1RM where applicable) for key movements.
Baseline and Week 5
Mobility Limitation (%)
Time Frame: Baseline and Week 5
Change from baseline in self-reported percentage limitation in daily functional tasks due to mobility restrictions.
Baseline and Week 5

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Heart Rate Variability (HRV - RMSSD)
Time Frame: Baseline and Week 5
Change from baseline in resting heart rate variability (RMSSD) as a biomarker of autonomic recovery.
Baseline and Week 5

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

MMSx Authority Institute for Movement Mechanics & Biomechanics Research Inc.

Collaborators

BodyGNTX Fitness Institute
GFFI Fitness Academy
Indian Institute of Kinesiology and Biomechanics Science (IIKBS)
Bureau of Fitness Standards (BFS)
Active India Health & Fitness Trust (AIHFT)
Body Mechanic Chain of Gyms
Shri Mahaveer Ortho Clinic
Regain Fitness Zone
MMSx Authority Biomechanics Department

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 10, 2025

Primary Completion (Estimated)

February 15, 2026

Study Completion (Estimated)

February 25, 2026

Study Registration Dates

First Submitted

November 18, 2025

First Submitted That Met QC Criteria

November 25, 2025

First Posted (Estimated)

December 1, 2025

Study Record Updates

Last Update Posted (Actual)

December 16, 2025

Last Update Submitted That Met QC Criteria

December 8, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • BPIT-MULTI-2025-001
  • MACREB-BPIT-2025-014 (Other Identifier: nstitutional Ethics Committee Approval Number (MMSx Authority / GFFI Ethics Committee))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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