Incidence, Treatment and Outcome After Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023. (AMIGO)

Incidence, Treatment of and Outcome of Acute Mesenteric Ischemia in the Region of Västra Götaland, 2000-2023 - a Retrospective Observational Study

The goal of this retrospective observational study is to describe the incidence and outcome of patients diagnosed with acute mesenteric ischemia (AMI) in the Västra Götaland region of Sweden between 2000-2023. The main questions it aims to answer are:

• What was the observed incidence and outcome, and how did it change during the time period?
• How did socioeconomic factors influence incidence and outcome of AMI?
• What main surgical approaches were selected for these patients?
• What was the distribution of anticoagulant use in the cohort, and what effect did the introduction of new oral anticoagulants (NOAC) have on incidence and mortality in AMI?
• What was the prevalence of Short Bowel Syndrome (SBS) after surgical intervention?

Participants were obtained from the regional diagnosis registry. Additional datapoints were obtained from the Swedish statistics bureau and pharmaceutical registers.

Study Overview

• Status: Active, not recruiting
• Conditions: Mesenteric Artery Ischemia

• Study Type: Observational
• Enrollment (Actual): 2446

Contacts and Locations

Study Locations

• Sweden
  • Gothenburg, Sweden
    • Sahlgrenska University Hospital
  • Västra Götaland County
    • Gothenburg, Västra Götaland County, Sweden, 41685
      • Sahlgrenska hospital/Östra hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Inhabitants of the Västra Götaland region in Sweden.

Description

Inclusion Criteria:

• all patients discharged from hospital with acute mesenteric ischemia (ICD K55.0 and K55.9)

Exclusion Criteria:

-

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
VG Region patients with AMI diagnosis 2000-2023; A cohort of all patients who were discharged with the diagnosis acute mesenteric ischemia (ICD-10: K55.0 or K55.9) in the Västra Götaland region of Sweden between 2000-01-01 and 2023-12-31.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of acute mesenteric ischemia	Annual incidence rate of acute mesenteric ischemia per 100,000 person-years in the Västra Götaland region.	Year 2000-2023
Mortality from acute mesenteric ischemia	All-cause mortality within up to 1 year of AMI diagnosis.	30 days, 90 days, 1 year.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Temporal trends in incidence and mortality	Change over time in incidence and mortality, including before and after introduction of non-vitamin K antagonist oral anticoagulants (NOACs).	Year 2000-2023
Socioeconomic determinants of incidence and outcome	Association between SES indicators (income, education, immigration status, geographic distance to care) and risk of AMI or mortality.	Year 2000-2023
Surgical management strategy	Proportion of patients undergoing bowel resection, revascularization (open or endovascular), or non-operative management.	Year 2000-2023
Prevalence of Short Bowel Syndrome (SBS)	Number and percentage of patients developing SBS (ICD-10 K91.2 and K90.8) after AMI.	Within 1 year of surgical intervention
Anticoagulant use patterns	Proportion of patients using vitamin-K antagonists, NOACs, antiplatelet therapy, or no anticoagulation; association with incidence and survival.	At AMI diagnosis; trends from 2000-2023

Collaborators and Investigators

• Sponsor: Sahlgrenska University Hospital
• Collaborators: Göteborg University; Gothia Forum - Center for Clinical Trial

Study record dates

Study Major Dates

• Study Start (Actual): February 24, 2025
• Primary Completion (Estimated): December 1, 2025
• Study Completion (Estimated): January 1, 2026

Study Registration Dates

• First Submitted: November 27, 2025
• First Submitted That Met QC Criteria: November 27, 2025
• First Posted (Actual): December 10, 2025

Study Record Updates

• Last Update Posted (Actual): December 10, 2025
• Last Update Submitted That Met QC Criteria: November 27, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Keywords: Epidemiology; Incidence; Mortality; Acute mesenteric ischemia; Mesenteric ischemia; Intestinal ischemia; Population-based cohort; Mesenteric arterial occlusion; Sweden / Västra Götaland
• Additional Relevant MeSH Terms: Vascular Diseases; Cardiovascular Diseases; Intestinal Diseases; Digestive System Diseases; Gastrointestinal Diseases; Peritoneal Diseases; Mesenteric Ischemia
• Other Study ID Numbers: 2024-04585-01

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data will not be shared. Due to Swedish data protection legislation and ethical restrictions, the de-identified dataset cannot be made publicly available. Only aggregated results will be published.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No