The Effect of Low Intensity With BFR on Stroke Patients

December 6, 2025 updated by: Ibrahim Ahmed Ibrahim Abu Ella, Delta University for Science and Technology

The Effect of Low Intensity Training With Blood Flow Restriction Versus Traditional Resistance Exercise on Lower Extermity Isokinetic Torque and Balance in Ischemic Stroke Patients

To compare the effects of low-intensity resistance training with blood flow restriction (BFR) versus traditional resistance training on lower limb isokinetic torque and dynamic balance in ischemic stroke survivors.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Ischemic stroke commonly results in reduced lower extremity muscle torque and impaired balance, affecting mobility and fall risk.

Traditional resistance training improves muscle function but may not be suitable for all patients due to the need for high mechanical loads.

Low-intensity resistance training with blood flow restriction (BFR) has emerged as an alternative that enhances muscular adaptation at lower loads. However, limited data exists on its effect on isokinetic torque and functional balance in stroke patients. This study aims to fill this gap using objective isokinetic measurements and validated balance scales.

Study Type

Interventional

Enrollment (Estimated)

80

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • • First-ever ischemic stroke (3-12 months post-stroke)

    • Aged 30-40 years
    • Can walk independently or with an aid
    • Medically stable and able to follow instructions

Exclusion Criteria:

  • •Hemorrhagic stroke

    • Deep vein thrombosis or peripheral vascular disease
    • Orthopedic conditions affecting lower limb
    • Severe cognitive impairment or uncontrolled hypertension

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Study group
Study group will receive low-intensity BFR resistance training
Other: low-intensity resistance training with blood flow restriction

"Low-Intensity" BFR Means (for Quads)

It involves resistance 20-30% 1RM combined with partial arterial + full venous restriction using a cuff placed on the proximal thigh.
Active Comparator: Control group
Control group will receive high intensity resistance training
Other: High intensity resistance training
High-intensity quadriceps training in stroke patients focuses on using 60-80% of 1RM to improve strength, motor unit recruitment, and functional mobility. Exercises such as loaded sit-to-stand, leg press, and step-ups are commonly used to target the quadriceps safely. Training intensity is guided by a perceived exertion of 7-9/10 while maintaining proper supervision to prevent falls. This approach enhances knee stability, gait efficiency, and overall functional independence.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Isokinetic torque
Time Frame: Baseline
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Delta University for Science and Technology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 13, 2025

Primary Completion (Estimated)

April 13, 2026

Study Completion (Estimated)

May 13, 2026

Study Registration Dates

First Submitted

December 6, 2025

First Submitted That Met QC Criteria

December 6, 2025

First Posted (Actual)

December 18, 2025

Study Record Updates

Last Update Posted (Actual)

December 18, 2025

Last Update Submitted That Met QC Criteria

December 6, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P.T.REC/012/005961

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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