"Facially Driven Digital Full-Mouth Rehabilitation"

Facially Driven Digital Workflow for Esthetic and Functional Full-mouth Rehabilitation

Participants with bite difficulties, smile dissatisfaction, and missing mandibular molars was rehabilitated using a fully digital, facially driven workflow. Integration of intraoral, facial, and CBCT data guided esthetic design, occlusion, and implant planning, resulting in precise alignment, functional occlusion, and esthetic restoration with veneers, zirconia crowns, TAD-assisted molar intrusion, and guided implants.

Study Overview

• Status: Recruiting
• Conditions: Malocclusion
• Intervention / Treatment: Device: Facially Driven, Fully Digital Full-Mouth Rehabilitation with Guided Implant Placement, TAD-Assisted Molar Intrusion, and Restorative Crowns/Veneers

Detailed Description

This Prospective study describes the comprehensive digital management of patients presenting with anterior open bite, smile dissatisfaction, and missing mandibular molars. A 3D virtual patient model was created by integrating intraoral scans, facial scans, and CBCT imaging, enabling prosthetically driven planning for esthetic and functional outcomes. Treatment involved conservative anterior rehabilitation with lithium disilicate veneers, full-coverage monolithic zirconia crowns, TAD-assisted intrusion of extruded molars, and guided implant placement for missing mandibular molars. The fully digital, facially guided workflow allowed precise restoration positioning, occlusal harmony, and predictable functional and esthetic results, demonstrating the utility of integrated digital planning in complex full-mouth rehabilitation.

• Study Type: Observational
• Enrollment (Estimated): 10

Contacts and Locations

• Study Contact: Name: Mohammed A. El-Sawy, PhD; Phone Number: 00201061314522; Email: Dr_sawy@windowslive.com

Study Locations

• Egypt
  • Menoufia
    • Shibīn al Kawm, Menoufia, Egypt
      • Recruiting
      • Faculty of Dentistry
      • Contact: Mohammed A. El-Sawy; Phone Number: 00201061314522; Email: Dr_sawy@windowslive.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 20-45 years with partial or complete edentulism, bite dysfunction, or esthetic concerns requiring full-mouth rehabilitation. Participants must be medically fit for implant and minor orthodontic procedures, have adequate bone for implant placement or be candidates for TAD-assisted tooth movement, and be willing to undergo treatment using a fully digital, facially guided workflow. Both male and female patients capable of providing informed consent and complying with follow-up visits are eligible.

Description

Inclusion Criteria:

• Adults aged 20-45 years with partial or complete edentulism requiring full-mouth rehabilitation.
• Patients with bite dysfunction, malocclusion, or esthetic concerns suitable for digital workflow treatment.
• Adequate bone volume for implant placement or candidates for TAD-assisted tooth movement.
• Willingness to undergo treatment using a fully digital, facially guided workflow and comply with follow-up visits.
• Ability to provide informed consent.

Exclusion Criteria:

• Systemic conditions contraindicating implant or surgical procedures (e.g., uncontrolled diabetes, immunosuppression).
• Active oral infections or untreated periodontal disease.
• Heavy smokers (>10 cigarettes/day) or substance abuse.
• History of head and neck radiation therapy or bisphosphonate use.
• Pregnancy or breastfeeding.
• Inability to comply with treatment or follow-up protocol.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Implant Stability	Clinical assessment: Absence of implant mobility assessed manually and using opposing instrument pressure. Radiographic assessment: Periapical radiographs using the paralleling technique to evaluate peri-implant bone levels. Success criteria: No progressive peri-implant radiolucency and marginal bone loss ≤ 1.5 mm during the first year, in accordance with Albrektsson et al. success criteria.	12 months post-treatment

Collaborators and Investigators

• Sponsor: Menoufia University
• Collaborators: Mansoura University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2024
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): December 30, 2026

Study Registration Dates

• First Submitted: December 2, 2025
• First Submitted That Met QC Criteria: December 30, 2025
• First Posted (Estimated): January 2, 2026

Study Record Updates

• Last Update Posted (Estimated): January 2, 2026
• Last Update Submitted That Met QC Criteria: December 30, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Stomatognathic Diseases; Tooth Diseases; Malocclusion
• Other Study ID Numbers: ADMNF-0051

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Up on reasonable request

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No