Glucose-fructose Ratio Pilot

January 14, 2026 updated by: Javier Gonzalez, University of Bath

PILOT TEST OF GLUCOSE-FRUCTOSE RATIOS ON EXOGENOUS CARBOHYDRATE OXIDATION RATES DURING EXERCISE

The aim of this pilot study is to estimate the effect size of changing the glucose-fructose ratio from 1:0.5 to 1:1 on exogenous carbohydrate oxidation rates during exercise, which can be used to power a future definitive study.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age: 18 years and above;
  • Performing endurance training for at least 5 hours per week
  • Capable of three hours of continuous exercise

Exclusion Criteria:

  • Glucose or lipid lowering, or weight loss medication
  • Diagnosis of cardiovascular disease, renal failure, liver disease or type 2 diabetes
  • Contraindications to exercise
  • Pregnant or lactating

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: One to One ratio
Glucose and fructose ingestion in a one-to-one ratio
Other: Glucose and fructose (one-to-one)
Glucose and fructose ingested in solution in a one-to-one ratio (135 grams per hour for 3 hours during exercise)
Active Comparator: Two to one ratio
Glucose and fructose ingestion in a two-to-one (1-to-0.5) ratio
Other: Glucose and fructose (two-to-one)
Glucose and fructose ingested in solution in a two-to-one ratio (135 grams per hour for 3 hours during exercise)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Exogenous carbohydrate oxidation rate (g/h)
Time Frame: 180 minutes
Total exogenous carbohydrate oxidation rate (g/h) over 180 minutes
180 minutes

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Peak exogenous carbohydrate oxidation rate (g/h)
Time Frame: 180 minutes
Highest recorded exogenous carbohydrate oxidation rate (g/h)
180 minutes
Whole-body carbohydrate oxidation rate (g/h)
Time Frame: 180 minutes
Total whole-body carbohydrate oxidation rate (g/h)
180 minutes
Endogenous carbohydrate oxidation rate (g/h)
Time Frame: 180 minutes
Total endogenous carbohydrate oxidation rate (g/h)
180 minutes
Whole-body fat oxidation rate (g/h)
Time Frame: 180 minutes
Total whole-body fat oxidation rate (g/h)
180 minutes
Blood lactate concentrations (mmol/L)
Time Frame: 180 mninutes
Mean blood lactate concentrations over 180 minutes
180 mninutes
Blood glucose concentrations (mmol/L)
Time Frame: 180 minutes
Mean blood glucose concentrations (mmol/L) over 180 minutes
180 minutes
Ratings of gut comfort (arbitrary units)
Time Frame: 180 minutes
Mean ratings of gut comfort (arbitrary units) over 180 minutes
180 minutes
Ratings of perceived exertion (arbitrary units)
Time Frame: 180 minutes
Mean ratings of perceived exertion (arbitrary units) over 180 minutes
180 minutes

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Exogenous carbohydrate oxidation over 2 hours (g/h)
Time Frame: 120 minutes
Total exogenous carbohydrate oxidation over 2 hours (g/h)
120 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Bath

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 14, 2026

Primary Completion (Estimated)

May 1, 2026

Study Completion (Estimated)

August 1, 2026

Study Registration Dates

First Submitted

January 14, 2026

First Submitted That Met QC Criteria

January 14, 2026

First Posted (Actual)

January 22, 2026

Study Record Updates

Last Update Posted (Actual)

January 22, 2026

Last Update Submitted That Met QC Criteria

January 14, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 11030 (DAIDS-ES)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Outcome measures in anonymised format.

IPD Sharing Time Frame

Upon publication in a peer-reviewed journal

IPD Sharing Access Criteria

Via the University of Bath Research Data Repository

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • ICF

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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