Evaluation of the Evolution of Proprioceptive Reweighting Abilities Following Anterior Cruciate Ligament Reconstruction Surgery (ReproEVO)

January 28, 2026 updated by: University Hospital, Brest

Evaluation of the Evolution of Proprioceptive Reweighting Abilities Following Anterior Cruciate Ligament Reconstruction Surgery - ReproEVO

Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%.

During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.

Athletes can thus be classified as plastic or rigid . Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Anterior cruciate ligament (ACL) injury is the most common knee injury among athletes who play contact sports involving pivoting. ACL reconstruction (ACLR) combined with rehabilitation is the standard treatment for ACL tears in athletes, and rehabilitation is one of the keys to success. The overall return to sport rate is 80%, but the return to pre-injury level of sport is only 65% and the return to the same level of competition is only 55%. The recurrence rate is close to 20%. Although the number of studies on the subject is growing, there is currently no consensus on rehabilitation protocols.

During rehabilitation and sports practice, proprioceptive information is essential for adjusting the muscle sensorimotor loop and enabling optimal movement.

We have demonstrated that athletes and athletes after ACL reconstruction show variability in the integration of proprioceptive information during a complex balance task.

Athletes can thus be classified as plastic (able to vary the source of proprioceptive information depending on conditions) or rigid (unable to do so).

Our hypothesis is to show that the proportion of "plastic" patients 9 months post-operative following ACL reconstruction is higher than that found in the same population 3 months post-operative, thus demonstrating the progression of proprioceptive integration abilities after ACL reconstruction surgery.

Study Type

Interventional

Enrollment (Estimated)

34

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
      • Brest, France, 29609
        • Brest University Hospital
        • Contact:
        • Principal Investigator:
          • Olivier REMY-NERIS, Professor
      • Montpellier, France, 34000
        • Montpellier University Hospital
        • Contact:
        • Principal Investigator:
          • Benoît ATTALIN, Doctor
      • Saint-Clément-de-Rivière, France, 34980
        • Dr. STER Clinic, Saint Clément de Rivière
        • Contact:
        • Principal Investigator:
          • François FEUVRIER, Doctor

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Aged between 15 and 40;
  • Patients with ACL rupture scheduled for ACL reconstruction surgery;
  • Patients able to maintain a stable bipedal standing position without technical assistance and with their eyes closed;
  • Consent of the patient, parents, legal guardians, or guardians to the recording (for minor patients) of data for research and publication purposes.

Exclusion Criteria:

  • Recent osteoarticular pathology (i.e., less than three months) of the lower limbs, whether traumatic or not, other than ACL rupture;
  • Proven disabling neurological pathology;
  • Pain in the musculoskeletal system during exercise (excluding the operated knee);
  • Fatigue assessed using the Borg scale > 6;
  • Skin allergy to an adhesive product.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Patients with Anterior Cruciate Ligament
Patients with Anterior Cruciate Ligament (ACL) rupture scheduled for ACL reconstruction surgery
Procedure: ReproEVO intervention

After the inclusion visit, each assessment will include an examination of standing balance in two support conditions: hard floor or soft floor and two conditions of vibration of the Achilles tendons or lumbar muscles, performed randomly over five trials for each condition. The subjects stand with their eyes covered by an opaque mask. Vibrators are positioned at both locations and vibrated randomly after a trial without recording to perceive the destabilizing effect induced by the vibration. The data is recorded using a force platform on the floor.

Subjects will be seated and strapped into a rigid device attached to their leg. The device is connected to a motor that maintains a constant speed. Maximum strength will be measured at two different speeds.

Finally, at each assessment, the subjects will complete questionnaires about their fear of pain, their assessment of their knee's capabilities, and the activities they engage in.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of progress in proprioceptive reweighting after knee ligament reconstruction
Time Frame: Baseline, 3 months after surgery and 9 months after surgery
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
Baseline, 3 months after surgery and 9 months after surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assesment of the variation in weighting between before and after the operation
Time Frame: Baseline and 3 months postoperatively
Difference between the mean proprioceptive reweighting coefficient (RPw) preoperatively and 3 months postoperatively
Baseline and 3 months postoperatively
Assess postural control
Time Frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Difference in the size of the shift in the center of pressure in a static standing position, with eyes open and closed
Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score
Time Frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess your Anterior Cruciate Ligament - Return to Sport and Injury (ACL-RSI) perception score (0 : Not at all sure; 10: Completely safe) at the inclusion visit (preoperative); at 3 months postoperatively and at 9 months postoperatively
Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess the subjective IKDC activity score
Time Frame: Baseline, at 3 months postoperatively and at 9 months postoperatively
Assess the subjective IKDC activity score (0: Never; 10: Always) at the inclusion visit (preoperative); at 3 months postoperatively and at 9 months postoperatively.
Baseline, at 3 months postoperatively and at 9 months postoperatively

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Brest

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

February 20, 2026

Primary Completion (Estimated)

May 20, 2028

Study Completion (Estimated)

May 20, 2028

Study Registration Dates

First Submitted

January 28, 2026

First Submitted That Met QC Criteria

January 28, 2026

First Posted (Actual)

February 5, 2026

Study Record Updates

Last Update Posted (Actual)

February 5, 2026

Last Update Submitted That Met QC Criteria

January 28, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 29BRC25.0312

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

All collected data that underlie results in a publication

IPD Sharing Time Frame

Data will be available after the publication of result and ending fifteen years following the last visit of the last patient

IPD Sharing Access Criteria

Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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