Pain Relief Following Laparoscopic Cholecystectomy While Comparing Intra Abdominal Versus Sub Cutaneous Local Anesthetic Administration

Comparative Evaluation of Analgesic Outcomes of Intra-peritoneal Versus Subcutaneous Infiltration of Bupivacaine for Laparoscopic Cholecystectomy Patients "

Laparoscopic cholecystectomy involves removal of gallbladder through small incision ports resulting in faster recovery. Small incisions are less painful and hence local anesthesis administered can be effective for pain management. This local anesthetic can be administered either within abdominal cavity or at sit of small incisions.

Study Overview

• Status: Recruiting
• Conditions: Local Anesthetic Infiltration; Laparoscopic Cholecystectomy Surgery; Analgeisa
• Intervention / Treatment: Drug: Intraoperitoneal local anesthetic administration; Drug: Sub cutaneous administration of local anesthetic

Detailed Description

Laparoscopic cholecystectomy is a minimally invasive surgical procedure involving removal of the gallbladder through multiple small trocar incisions. Compared with open surgery, this approach is associated with reduced postoperative pain, shorter hospital stay, and faster recovery. Despite its minimally invasive nature, postoperative pain remains a significant concern, particularly at port sites and from intraperitoneal irritation. Local anesthetic techniques have been shown to contribute to multimodal analgesia in laparoscopic surgery. Local anesthetic agents may be administered either intraperitoneally or by infiltration at trocar insertion sites to reduce postoperative pain and opioid requirements. However, the optimal route of local anesthetic administration for effective postoperative analgesia following laparoscopic cholecystectomy remains uncertain, warranting further clinical evaluation.

• Study Type: Interventional
• Enrollment (Estimated): 100
• Phase: Phase 4

Contacts and Locations

• Study Contact: Name: Nimrah Iqbal Prinicpal Investigator, MBBS; Phone Number: +92 335 0526611; Email: drnimrahiqbal@gmail.com

Study Locations

• Pakistan
  • Punjab Province
    • Rawalpindi, Punjab Province, Pakistan
      • Recruiting
      • Rawalpindi Teaching Hospital, Rawalpindi

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• ASA I and II

Exclusion Criteria:

• Allergic to local anesthetic Open cholecystectomy History of chronic pain History of abdominal surgery

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Intraperitoneal local anesthetic administration	Drug: Intraoperitoneal local anesthetic administration; Intraperitoneal infiltration of 20ml of 0.25% Bupivacaine will be done at the end of procedure by the surgeon.
Active Comparator: Sub cutaneous local anesthetic administration	Drug: Sub cutaneous administration of local anesthetic; port site infiltration of 20ml of 0.25% Bupivacaine will be done. 6ml for 10mm ports and 4ml for 5mm ports respectively.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Post opestive pain score	This will be measured using Visual Analog score upon arrival at post anesthesia care unit labelled as Time 0 then at time intervals 3h,6h, 12h and 24 hours post operatively
Rescue analgesia demand	This will be the number of patients requiring resuce analgesia in 24h post operative period. Rescue analgesia will be administered if VAS score >4

Collaborators and Investigators

• Sponsor: Rawalpindi Medical College
• Investigators: Study Chair: Waqas Anjum, Rawalpindi Medical College

Publications and helpful links

General Publications

• Bano N, Hayat N, Saleem S, Javaid F, Rehman A, Mudassir. Comparison of intraincisional and intraperitoneal infiltration of local anaesthetic in laparoscopic cholecystectomy to control early postoperative pain. Professional Med J 2021; 28(2):192-196. https://doi.org/10.29309/TPMJ/2021.28.02.6013

Study record dates

Study Major Dates

• Study Start (Actual): January 17, 2026
• Primary Completion (Estimated): June 17, 2026
• Study Completion (Estimated): June 17, 2026

Study Registration Dates

• First Submitted: January 19, 2026
• First Submitted That Met QC Criteria: February 12, 2026
• First Posted (Actual): February 13, 2026

Study Record Updates

• Last Update Posted (Actual): February 13, 2026
• Last Update Submitted That Met QC Criteria: February 12, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Keywords: Laparoscopic cholecystectomy; Post Operative analgesia; Local anesthetic administration
• Other Study ID Numbers: 4726/RTH/RWP

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Hospital ethical committee doesnt allow

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No