- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT07417475
Robot-Assisted Radical Prostatectomy: the HOOD Technique Versus Standard Anterior Reconstruction
February 11, 2026 updated by: Araz Musaev
Early Functional Outcomes After Robot-Assisted Radical Prostatectomy: A Prospective Comparison of the HOOD Technique Versus Standard Anterior Reconstruction
This prospective, non-randomized cohort study included consecutive patients undergoing robotic-assisted laparoscopic radical prostatectomy (RARP) between January 2024 and January 2026 following ethics committee approval.
Patients with clinically localized prostate cancer eligible for bilateral nerve-sparing surgery were enrolled.
Two surgical techniques-anterior-posterior reconstruction (APR) and the HOOD technique-were compared.
All procedures were performed by a single high-volume surgeon at a tertiary referral center.
The primary endpoint was early urinary continence recovery, assessed at catheter removal and at 3, 6, and 12 weeks postoperatively.
Secondary outcomes included postoperative complications, positive surgical margin rates, and early oncological outcomes.
Study Overview
Status
Completed
Conditions
Study Type
Interventional
Enrollment (Actual)
200
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Ankara, Turkey (Türkiye)
- Ankara Universtity School of medicine department of urology
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- life expectancy >10 years,
- clinically organ confined disease (cT1-cT2),
- biopsy ISUP GG ≤3,
- total serum prostate-specific antigen (PSA) ≤10 ng/ml
- normal preoperative continence and potency
Exclusion Criteria:
- high risk prosatate cancer
- cN1
- M1 prostate cancer (according to preoperative GA68 PSMA PET CT)
- pre-existing urinary incontinence,
- previous prostatic, urethral, bladder neck surgery
- neoadjuvant therapy
- prior pelvic radiotherapy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: HOOD technique
|
Prostatectomy with the HOOD (Hood technique) is a nerve-sparing approach in which the anterior periprostatic structures, including the detrusor apron and puboprostatic ligaments, are preserved to maintain anterior urethral support and neurovascular integrity, with the aim of improving early urinary continence and functional recovery after radical prostatectomy.
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Active Comparator: Anterior-Posterior reconstruction
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Prostatectomy with anterior-posterior reconstruction involves restoration of both the posterior musculofascial plate and the anterior periurethral support structures during vesicourethral anastomosis, aiming to re-establish normal pelvic anatomy and improve early postoperative urinary continence following radical prostatectomy.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Functional outcomes
Time Frame: 3 weeks , 6 weeks and 12 weeks after surgery.
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The Urinary continance recovery rates at the catheter removal, and subsequently at 3 weeks , 6 weeks and 12 weeks after surgery.
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3 weeks , 6 weeks and 12 weeks after surgery.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Heesakkers J, Farag F, Bauer RM, Sandhu J, De Ridder D, Stenzl A. Pathophysiology and Contributing Factors in Postprostatectomy Incontinence: A Review. Eur Urol. 2017 Jun;71(6):936-944. doi: 10.1016/j.eururo.2016.09.031. Epub 2016 Oct 6.
- Mandel A, Choudhary M, Tillu N, Maheshwari A, Kolanukuduru K, Wagaskar V, Tewari A. Hood Technique for Radical Prostatectomy. J Endourol. 2025 Mar;39(S1):S35-S38. doi: 10.1089/end.2024.0303.
- Turkolmez K, Akpinar C, Kubilay E, Suer E. Retzius-Sparing vs Modified Anatomical Structure Preserving and Retzius-Repairing Robotic-Assisted Radical Prostatectomy: A Prospective Randomized Comparison on Functional Outcomes with a 1-Year Follow-Up. J Endourol. 2022 Sep;36(9):1214-1222. doi: 10.1089/end.2022.0073. Epub 2022 Jun 2.
- Tewari AK, Bigelow K, Rao S, Takenaka A, El-Tabi N, Te A, Vaughan ED. Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar: a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy. Urology. 2007 Apr;69(4):726-31. doi: 10.1016/j.urology.2006.12.028.
- Student V Jr, Vidlar A, Grepl M, Hartmann I, Buresova E, Student V. Advanced Reconstruction of Vesicourethral Support (ARVUS) during Robot-assisted Radical Prostatectomy: One-year Functional Outcomes in a Two-group Randomised Controlled Trial. Eur Urol. 2017 May;71(5):822-830. doi: 10.1016/j.eururo.2016.05.032. Epub 2016 Jun 6.
- Porpiglia F, Bertolo R, Manfredi M, De Luca S, Checcucci E, Morra I, Passera R, Fiori C. Total Anatomical Reconstruction During Robot-assisted Radical Prostatectomy: Implications on Early Recovery of Urinary Continence. Eur Urol. 2016 Mar;69(3):485-95. doi: 10.1016/j.eururo.2015.08.005. Epub 2015 Aug 19.
- Mather JS. Impossible direct laryngoscopy in achondroplasia. A case report. Anaesthesia. 1966 Apr;21(2):244-8. doi: 10.1111/j.1365-2044.1966.tb02607.x. No abstract available.
- Cambio AJ, Evans CP. Minimising postoperative incontinence following radical prostatectomy: considerations and evidence. Eur Urol. 2006 Nov;50(5):903-13; discussion 913. doi: 10.1016/j.eururo.2006.08.009. Epub 2006 Aug 28.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2024
Primary Completion (Actual)
January 1, 2026
Study Completion (Actual)
January 1, 2026
Study Registration Dates
First Submitted
February 11, 2026
First Submitted That Met QC Criteria
February 11, 2026
First Posted (Actual)
February 18, 2026
Study Record Updates
Last Update Posted (Actual)
February 18, 2026
Last Update Submitted That Met QC Criteria
February 11, 2026
Last Verified
February 1, 2026
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Urogenital Diseases
- Genital Diseases
- Genital Neoplasms, Male
- Urogenital Neoplasms
- Neoplasms by Site
- Neoplasms
- Genital Diseases, Male
- Prostatic Diseases
- Male Urogenital Diseases
- Neoplasms by Histologic Type
- Neoplasms, Glandular and Epithelial
- Carcinoma
- Prostatic Neoplasms
- Adenocarcinoma
- Surgical Procedures, Operative
- Urologic Surgical Procedures
- Urogenital Surgical Procedures
- Urologic Surgical Procedures, Male
- Prostatectomy
Other Study ID Numbers
- İ01-86-26
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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