Comparison of Rate and Amount of Orthodontic Space Closure (Premolar)

February 28, 2026 updated by: Dow University of Health Sciences

Comparison of Rate and Amount of Orthodontic Space Closure After All First Premolars Extraction in Healed vs Fresh Extraction Sites. A Randomized Clinical Trial.

The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is to calculate rate and amount of space closure between fresh vs healed as well as maxilla and mandible.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The mandibular and maxillary arches of 34 patients will be included whose treatment plan decision was the extraction of all first premolars. Due to the split mouth approach, patients' maxillary and mandibular arches are randomly subdivided into two groups (right and left sides). First premolar extraction spaces in Group 1 will be closed once they have healed (6 week), while first premolar extraction spaces in Group 2 will be closed immediately after extraction. Both the upper and lower extraction spaces will be closed using coil springs (magnitude of force 30g per side). We'll specify the following time intervals: T1: Immediately prior to space closure; T2: 1 month after initial space closure; T3: 2 months after initial space closure T3: 3 months after initial space closure. Records will include measuring the rate and amount of space closure through Vernier calipers on dental cast as well as intraorally and will be evaluated at each time point.

Study Type

Interventional

Enrollment (Actual)

34

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
    • Sindh
      • Karachi, Sindh, Pakistan, 75300
        • Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Patients aged 18-35 years.
  • Patients undergoing fixed appliance treatment.
  • Good oral hygiene and periodontal support.
  • Patients with all first premolar's extraction treatment plan.
  • Atraumatic extraction.

Exclusion Criteria:

  • History of previous orthodontic treatment
  • Systemic diseases like diabetes, hypertension etc
  • Any bone pathology or taking medicines like bisphosphonates
  • Patients with clefts or any syndromic condition.
  • Patients with old extraction socket.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: fresh vs healed extraction socket
Comparison of rate and amount of space closure in fresh vs healed extraction socket
Procedure: Space Closure
Space Closure in fresh vs healed extraction socket
Other Names:
  • Extraction

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To compare rate of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.
Time Frame: four time points are taken. T0: Baseline, T1: One month, T2: Two months, T3: Three months
This study will be useful in making the timely decision for extraction of premolars and estimation of orthodontic treatment duration as well.
four time points are taken. T0: Baseline, T1: One month, T2: Two months, T3: Three months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To compare amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.
Time Frame: Space closure at T3 is subtracted from T0
Total space closure
Space closure at T3 is subtracted from T0

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Dow University of Health Sciences

Investigators

  • Study Director: Sadia Rizwan, BDS, FCPS, CHPE, Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 15, 2023

Primary Completion (Actual)

December 20, 2023

Study Completion (Actual)

February 9, 2024

Study Registration Dates

First Submitted

January 29, 2026

First Submitted That Met QC Criteria

February 28, 2026

First Posted (Actual)

March 3, 2026

Study Record Updates

Last Update Posted (Actual)

March 3, 2026

Last Update Submitted That Met QC Criteria

February 28, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • BAnis

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

There is no need to share individual participants data

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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