Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents (LAST)

March 10, 2026 updated by: Faruk Cicekci, Selcuk University

Evaluation of the Effectiveness of a Local Anesthetic Systemic Toxicity (LAST) Knowledge Training Program for Non-Anesthesiologist Surgical Residents

This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical residents. Guided by Kirkpatrick's evaluation model, the study investigates improvements in knowledge, technical and non-technical skills, and the retention of these competencies one month after training

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Detailed Description

Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication of regional anesthesia. Advances in ultrasound-guided blocks have reduced its incidence, yet LAST remains a major concern due to severe cardiovascular and neurological risks. The American Society of Regional Anesthesia and Pain Medicine (ASRA) recommends early lipid emulsion therapy and emphasizes proper training. Simulation-based multidisciplinary training provides a dynamic and immersive experience, improving both technical and behavioral skills. This trial applies Kirkpatrick's four-level model (reaction, learning, behavior, results) to assess the training program. Primary endpoint: improvement in knowledge test scores. Secondary endpoints: OSCE performance, satisfaction, and key performance indicators related to simulated LAST management.

Study Type

Interventional

Enrollment (Estimated)

102

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey (Türkiye)
      • Konya, Turkey (Türkiye), 42250
        • Selcuk Universitesi, School of Medicine, Anesthesiology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Surgical residents (General Surgery, Orthopedics, Obstetrics & Gynecology, Dentistry) on active rotation at Selçuk University Faculty of Medicine.
  2. Voluntary participation with written informed consent.
  3. No prior comprehensive LAST training in the last 12 months.

Exclusion Criteria:

  1. Prior comprehensive LAST training or instructor experience in the last 12 months.
  2. Anesthesiology residents or specialists.
  3. Unable to complete follow-up due to rotation change or leave.
  4. Declining or withdrawing consent.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Structured Training Group
Experimental: Structured Training Group - Local Anesthetic Systemic Toxicity (LAST) pretest application, then Kirkpatrick-based program (2-3 hours; theoretical + simulation/OSCE). Includes theoretical (pathophysiology, risk factors, prevention, lipid therapy algorithm) and practical modules (simulation scenario, OSCE checklist, structured feedback). Local Anesthetic Systemic Toxicity (LAST) lasttest application It is assumed that a higher test score indicates a higher level of knowledge on the topic.
Behavioral: Education
Local Anesthetic Systemic Toxicity (LAST); Simulation-based Education; Perioperative Training
Experimental: Control
Control: Standard Training Group (Wait-list Control) - Routine anesthesia training during standard rotation. Structured training provided after study completion.
Behavioral: Education
Local Anesthetic Systemic Toxicity (LAST); Simulation-based Education; Perioperative Training

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Knowledge improvement (Learning outcome)
Time Frame: Baseline (Day 0) to immediately post-training.
Local Anesthetic Systemic Toxicity (LAST) Knowledge Level and Awareness Test Change in 25-item multiple-choice test score (Δ = post-test - pre-test) Scoring: 0-25. It is accepted that as the score obtained for the test increases, the level of knowledge about the subject increases.
Baseline (Day 0) to immediately post-training.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Selcuk University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 15, 2025

Primary Completion (Estimated)

February 28, 2026

Study Completion (Estimated)

February 28, 2026

Study Registration Dates

First Submitted

September 22, 2025

First Submitted That Met QC Criteria

March 10, 2026

First Posted (Actual)

March 11, 2026

Study Record Updates

Last Update Posted (Actual)

March 11, 2026

Last Update Submitted That Met QC Criteria

March 10, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • farukcicekci9

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

De-identified individual participant data will be made available from the corresponding author upon reasonable request after publication of the article.

IPD Sharing Time Frame

1 year

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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