Effect of Scoliosis and Progressive Resistance Exercises on Clinical and Pulmonary Parameters in Adolescents With Idiopathic Scoliosis (SPRE-AIS)

March 31, 2026 updated by: Gökçe Doğrayıcı, Ankara City Hospital Bilkent

Effects of Scoliosis Exercises and Upper and Lower Extremity Progressive Resistance Exercises on Anthropometric, Clinical, and Pulmonary Parameters in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that may affect physical function and pulmonary capacity during adolescence. Exercise-based rehabilitation programs are frequently used in the conservative management of scoliosis.

The aim of this study is to investigate the effects of scoliosis-specific exercises combined with upper and lower extremity progressive resistance exercises on anthropometric, clinical, and pulmonary parameters in adolescents with idiopathic scoliosis.

Participants diagnosed with adolescent idiopathic scoliosis will participate in an exercise program including scoliosis-specific exercises and progressive resistance exercises targeting upper and lower extremities. Anthropometric measurements, clinical assessments, and pulmonary function parameters will be evaluated before and after the intervention.

The results of this study are expected to provide evidence regarding the effectiveness of combined exercise interventions on physical and respiratory outcomes in adolescents with idiopathic scoliosis.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Adolescent idiopathic scoliosis (AIS) is characterized by a three-dimensional spinal deformity that can influence posture, musculoskeletal balance, and respiratory function. Conservative treatment approaches often include physiotherapy-based exercise programs aimed at improving spinal alignment, muscle strength, and overall functional capacity.

In this study, adolescents diagnosed with idiopathic scoliosis will undergo an exercise intervention consisting of scoliosis-specific exercises combined with progressive resistance exercises targeting upper and lower extremity muscle groups. The intervention program aims to improve musculoskeletal strength, posture, and respiratory function.

Anthropometric measurements, clinical parameters, and pulmonary function values will be assessed before and after the exercise program. These outcomes will help evaluate the effectiveness of the intervention in improving physical and respiratory parameters in adolescents with idiopathic scoliosis.

The findings of this study may contribute to the development of effective rehabilitation strategies for adolescents with idiopathic scoliosis and support evidence-based physiotherapy practices.

Study Type

Interventional

Enrollment (Actual)

24

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Adolescents aged between 12 and 18 years diagnosed with adolescent idiopathic scoliosis (AIS)
  • Cobb angle between 10° and 25° confirmed by radiological evaluation
  • C-type scoliosis curve pattern

Exclusion Criteria:

  • Presence of congenital scoliosis
  • Presence of chromosomal abnormalities
  • Presence of skeletal dysplasia
  • Presence of connective tissue disease
  • Presence of neuromuscular disease
  • Presence of metabolic diseases affecting bone metabolism
  • Calcium metabolism disorders
  • Severe autoimmune diseases
  • Severe endocrine diseases
  • Severe cognitive impairment
  • Orthopedic conditions preventing participation in exercise
  • History of spinal surgery
  • History of excisional procedure or surgery involving paravertebral muscles

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Scoliosis Exercise Program
Participants perform scoliosis-specific exercises designed to improve spinal alignment, posture, and respiratory function.
Behavioral: Scoliosis Exercises
Scoliosis-specific exercise program designed to improve spinal alignment, posture, and respiratory function in adolescents with idiopathic scoliosis. The program includes supervised therapeutic exercises performed under physiotherapist guidance.
Experimental: Progressive Resistance Exercise Program
Participants perform upper and lower extremity progressive resistance exercises targeting major muscle groups.
Behavioral: Progressive Resistance Exercises
Progressive resistance exercise program targeting upper and lower extremity muscle groups including biceps, triceps, pectoral, back, quadriceps, and hamstring muscles.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Muscle Thickness Measured by Ultrasonography
Time Frame: Baseline (Week 0), Week 4, and Week 8
Changes in diaphragm, lumbar multifidus and pectoralis major muscle thickness measured by ultrasonography.
Baseline (Week 0), Week 4, and Week 8

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Sit and Reach Flexibility Test
Time Frame: Baseline (Week 0), Week 4, and Week 8
Flexibility assessment using the sit and reach test to evaluate hamstring and lower back flexibility before and after the intervention.
Baseline (Week 0), Week 4, and Week 8
Back Scratch Test
Time Frame: Baseline (Week 0), Week 4, and Week 8
Shoulder flexibility assessment using the back scratch test before and after the intervention.
Baseline (Week 0), Week 4, and Week 8
Hand Grip Strength
Time Frame: Baseline (Week 0), Week 4, and Week 8
Upper extremity muscle strength measured using a hand dynamometer.
Baseline (Week 0), Week 4, and Week 8
Pulmonary Function Test
Time Frame: Baseline (Week 0), Week 4, and Week 8
Pulmonary function parameters including FVC and FEV1 measured using spirometry.
Baseline (Week 0), Week 4, and Week 8

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ankara City Hospital Bilkent

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2025

Primary Completion (Actual)

January 30, 2026

Study Completion (Actual)

January 30, 2026

Study Registration Dates

First Submitted

March 15, 2026

First Submitted That Met QC Criteria

March 15, 2026

First Posted (Actual)

March 18, 2026

Study Record Updates

Last Update Posted (Actual)

April 6, 2026

Last Update Submitted That Met QC Criteria

March 31, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 481360

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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