Tinder Fungus as an Adjunct to Non-surgical Periodontal Therapy for Periodontitis

Tinder Fungus (Fomes Fomentarius) as an Adjunct to Non-surgical Periodontal Therapy for Periodontitis: A Randomized Controlled Trial

The goal of this interventional clinical study is to learn if a Tinder fungus-based formulation -specifically a toothpaste and oral supplement powder-works as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis.

The main questions it aims to answer is:

• Does the Tinder fungus-based formulation as an adjunct to NSPT reduce bleeding on probing more than a commercially available toothpaste as an adjunct to NSPT? Researchers will compare tinder fungus toothpaste and oral powder as an adjunct to NSPT to a commercially available toothpaste as an adjunct to NSPT to see if the Tinder fungus-based formulation works as adjuncts to NSPT in patients with periodontitis.

Participants will:

• Take tinder fungus toothpaste and oral powder or a commercially available toothpaste as an adjunct to NSPT twice daily for 30 consecutive days
• Visit the clinic at least twice including a visit before and after the intervention
• Keep a diary documenting their well-being and the number of times they used the toothpastes in the morning and evening.

Study Overview

• Status: Not yet recruiting
• Conditions: Periodontitis
• Intervention / Treatment: Other: Tinder fungus-based formulation; Other: Commercially available toothpaste

• Study Type: Interventional
• Enrollment (Estimated): 70
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Austria
  • Vienna
    • Vienna, Vienna, Austria, 1020
      • Dental Clinic of the Sigmund Freud Private University
      • Contact: Hady Haririan, Prof,Dr,PhD,MSc; Phone Number: +4317201966; Email: hady.haririan@med.sfu.ac.at
      • Principal Investigator: Brenda Laky, PD,MSc,PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Patients diagnosed with Stage III or IV periodontitis
• Patients who have not yet initiated periodontal therapy
• Patients who have at least 20 remaining teeth
• Patients who are willing to use an electric toothbrush
• Patients who are willing to use interdental brushes

Exclusion Criteria:

• Patients who have previously received treatment for periodontitis
• Patients who have already undergone or initiated periodontal therapy
• Patients with a known allergy or intolerance to any component of the toothpaste or the powder
• Patients who are already using a product that contains tinder fungus (Fomes fomentarius)
• Patients who, at the time of periodontal treatment, are undergoing active systemic cancer therapy (e.g., chemotherapy or immunotherapy) or radiotherapy in the head and neck region, or for whom such therapy is planned. Previous illnesses or completed therapies do not constitute an exclusion criterion, provided that no current or planned treatment exists that could influence the periodontal treatment outcome or pose an increased risk for the participants.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Tinder fungus-based formulation (toothpaste and oral supplement powder); Tinder fungus toothpaste plus oral supplement powder as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis	Other: Tinder fungus-based formulation; Participants will receive Tinder fungus (Fomes fomentarius)-based formulations including a toothpaste plus an oral supplement powder as adjuncts to non-surgical periodontal therapy (NSPT).
Active Comparator: commercially available toothpaste; Commercially available toothpaste as adjuncts to non-surgical periodontal therapy (NSPT) in patients with periodontitis	Other: Commercially available toothpaste; A standard commercially available toothpaste administered as an adjunct to NSPT.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Bleeding on probing (BoP in %) change	Bleeding on probing (BoP in %) changes from baseline (T0) to reevaluation (T1). BOP will be recorded as yes/no for each of 6 sites and reported as the percentage of affected sites per participant.	changes from baseline (T0; 1 day before intervention starts) to reevaluation (T1; 5 weeks (±1 week) after intervention start)

Collaborators and Investigators

• Sponsor: Sigmund Freud PrivatUniversitat

Study record dates

Study Major Dates

• Study Start (Estimated): February 1, 2026
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2028

Study Registration Dates

• First Submitted: March 10, 2026
• First Submitted That Met QC Criteria: March 16, 2026
• First Posted (Actual): March 19, 2026

Study Record Updates

• Last Update Posted (Actual): March 19, 2026
• Last Update Submitted That Met QC Criteria: March 16, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontitis
• Other Study ID Numbers: 19113705

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No