Comparison of the Effects of Different Chest Techniques on University Students With Smoking Addiction

Comparison of the Effects of Chest PNF Techniques and Chest Mobility Exercises on Respiratory Function, Chest Expansion, and Functional Capacity in University Students With Smoking Addiction: A Single-Blind Randomized Controlled Study

Smoking is a significant risk factor for heart, lung, and respiratory system diseases, and is particularly prevalent among young people and university students. In Turkey, tobacco use is high in the 15-24 age group, and smoking rates among university students are reported to be between 20% and 43%. Besides causing COPD and other respiratory diseases, smoking negatively impacts performance by increasing fatigue, dyspnea, and pain during exercise. It impairs lung function, reducing respiratory volumes such as FVC and FEV1. PNF and chest mobility exercises targeting the chest area can improve respiratory parameters by increasing respiratory muscle function and thoracic mobility. Recent studies show that chest PNF techniques have positive effects on lung function, chest expansion, and some physiological parameters, especially in smokers.

Study Overview

• Status: Recruiting
• Conditions: Smoking
• Intervention / Treatment: Other: Chest PNF Techniques Group; Other: Chest Mobility Exercises Group

Detailed Description

Smoking, due to the various chemical substances it contains, constitutes a risk factor for many diseases, primarily heart and lung diseases. It has been reported that smoking rates are higher among students living in underdeveloped or developing countries. Most users start smoking at a young age. Figures show that 31.9% of individuals aged 15-24 in Türkiye use tobacco (CDC, 2016). While there is no national study on universities across Turkey, studies report smoking prevalence rates ranging from 20.6% to 43.6%. Due to harmful substances like nicotine, smoking can lead to COPD, atherosclerosis, and other respiratory diseases. Furthermore, individuals who smoke are more likely to stop exercising due to fatigue, dyspnea, and pain. Smoking negatively impacts lung capacity, reducing FVC, FEV1, and FEV1/FVC volumes while increasing RV volume. Proprioceptive neuromuscular facilitation (PNF) techniques targeting the chest area are used in various populations to enhance respiratory muscle function and improve respiratory parameters. Improvements in range of motion, flexibility, and thoracic congruence can be achieved through both active and passive chest mobility exercises. Lengthening of the intercostal muscles allows for more efficient contraction. The underlying mechanism of chest mobility exercises involves increasing intercostal muscle length, facilitating effective muscle contraction. Facilitating the downward movement of the diaphragm and increasing the forward and backward movement capability of both the superior and inferior costal muscles improves the biomechanics of chest movement. Intercostal muscle rotation is best achieved by fully retracting the chest wall. Chest PNF technique has only recently begun to be used in smokers. Studies have shown that chest PNF techniques positively improve lung function and chest expansion in male smokers. A study conducted on female smokers showed that chest PNF technique followed by breathing exercises regulated blood pressure.

Objective: The aim of study is to compare the effectiveness of chest PNF techniques and chest mobility exercises in university students who are smokers. Study Hypotheses:

H0: There is no difference between chest PNF techniques and chest mobility exercises in respiratory functions, chest expansion, and functional capacity in university students who are smokers.

H1: There is a difference between chest PNF techniques and chest mobility exercises in respiratory functions, chest expansion, and functional capacity in university students who are smokers.

H2: The effects of chest PNF techniques on respiratory functions, chest expansion, and functional capacity in university students who are smokers are not different from the control group.

H3: The effects of chest PNF techniques on respiratory functions, chest expansion, and functional capacity in university students who are smokers are different from the control group.

H4: The effects of chest mobility exercises on respiratory functions, chest expansion, and functional capacity in university students who are smokers are not different from the control group. H5: The effects of chest mobility exercises on respiratory function, chest expansion, and functional capacity differ in university students who are smokers compared to the control group.

Scope: This research is a prospective experimental study. The study will be conducted on 30 individuals who meet the inclusion criteria. The study population will be formed through announcement and invitation, and interventions will be implemented at the Yalova University Physiotherapy and Rehabilitation Application and Research Center.

Method: In calculating the minimum sample size for the study, FEV1 was used as the primary variable, and the effect size was calculated by considering data from a previous study in the literature that investigated the effectiveness of exercise in smoking addiction. Using the GPower 3.1 program, with a 95% confidence interval, 90% power, and Cohen's f=0.7797218 effect size, the calculation revealed that the minimum sample size for the study should be 27 individuals. Considering participant dropout and data loss, 10% more participants will be included. Accordingly, the study is planned to be conducted with 30 people. Participants will be included in the study through invitation and announcement. The study will be conducted with individuals who meet the inclusion criteria. Participants will be randomized into 3 groups: Chest PNF Techniques, Chest Mobility Exercises, and Control. This randomization will be performed using randomizer.org, an open-access randomization site. Both groups will be evaluated during the initial interview, and after completing an informed consent form, the participants will be informed about the process. The study will be conducted on individuals with smoking addiction. The inclusion criteria include a Fagerström Nicotine Dependence Questionnaire score of ≥4, which is considered indicative of nicotine dependence. Turkish validity and reliability were established by Uysal et al.

Data Collection Tools:

Demographic Information, Pulmonary Function Test Measurements are taken with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) while the person is in a seated position, Dyspnea Assessment: Modified Medical Research Council, Functional Capacity Assessment: Six-Minute Walk Test - 6MWT, Depression Assessment: The Beck Depression Inventory (BDI), Quality of Life Assessment: Patients' quality of life will be assessed using the Short Form-36 (SF-36), Chest Expansion: Chest expansion was assessed by measuring the circumference of the chest wall at maximum inspiration and maximum expiration, Fatigue: Patients' fatigue was assessed using the Turkish adaptation of the Fatigue Severity Scale, Physical Activity Level Assessment: International Physical Activity Questionnaire Short Form - IPAQS, Harvard Step Test: This test, used to measure cardiopulmonary endurance and physical fitness, involves individuals climbing and descending steps for 5 minutes.

Group Exercise Programs:

The Chest PNF Techniques and Chest Mobility Exercises group will receive treatment for a total of 6 weeks, with 3 sessions of 30 minutes per week. The control group will not receive any treatment.

Chest PNF Techniques Group: Chest PNF exercises will be performed in supine, side, and prone positions. The combined isotonic contractions technique will be used to improve respiratory control. Each technique will be performed for 12 repetitions. In all positions, the patient is first asked to exhale. Pressure and stretching are applied in the opposite direction of the movement. While the patient inhales, the physiotherapist controls the resistance to allow movement. If necessary, more resistance is applied to stronger areas to distribute the force to weaker areas. Supine position: Both hands are placed on the sternum and pressure is applied obliquely downwards. The hands are placed parallel and diagonally on the lateral chest wall, over the lower ribs. To focus on the upper chest area, the hands are similarly placed on the pectoral muscles.

Side-lying position: Both hands are placed parallel and diagonally on the lateral chest wall, over the lower ribs. This position is beneficial in distributing the force to the upper chest movement as it will provide resistance to the lower chest movement.

Prone position: Hands are placed parallel and diagonally on the lower ribs. In the forearm support position, one hand is placed on the sternum and the other hand on the intercostal region Chest Mobility Exercises Group: Chest mobility exercises will be performed. The exercises will be performed in combination with diaphragmatic breathing exercises, with 18-20 repetitions and 30-second breaks.

Chest rotation: The person is in a supine position. They extend their arms into an inverted T position. The physiotherapist places their hands on the underside of the rib cage and applies stress in the opposite direction.

Passive lateral flexion in side lying position: The person is positioned in a side lying position with their arms hanging down from the stretcher, supported by a pillow. The therapist performs passive flexion of the rib cage from the head to the left and right sides, with slight overextension in the final range.

Thoracic facet joint mobilization in supine position: The physiotherapist places one hand on the person's thoracic region and the other on the chest, and performs mobilization with the person lying supine with their arms crossed in front.

Trunk rotation in sitting position: The physiotherapist stands behind the person in a sitting position. They actively and passively rotate the trunk on both sides.

Arm movement in front of the chest while sitting: While sitting, the person raises their arms. While exhaling, they raise their arms above their head, then slowly lower them while inhaling. Cat-camel exercise: While in a crawling position, inhale, arch your back, and bring your head forward. Then, exhale, lower your back towards the ground and extend your head backward.

Pectoral stretch: With elbows bent and hands clasped behind the neck, hold the shoulder in abduction and stretch the pectoralis major muscle. Breathe diaphragmatically through the nose for 4 seconds and exhale through the mouth for 6 seconds. Encourage chest opening while inhaling.

Chest movement in crawling position: While in a crawling position, try to bring one hand towards the opposite knee, return to the starting position, rotate the trunk, and perform upper extremity flexion and abduction. Repeat for the opposite side.

Control Group: No intervention will be performed. Statistical Analysis The data obtained in the study will be loaded into the SPSS 26.0 software package and analyzed. Numerical data will be presented as mean and standard deviation; categorical data will be presented as number and percentage. Normality will be analyzed using the Shapiro-Wilks test. For within-group comparisons between pre-tests and post-tests, a paired t-test will be used if the assumptions of normal distribution are met; otherwise, the Wilcoxon signed-rank test will be used. For between-group comparisons, a one-way ANOVA test and the Tukey test (post-hoc test) will be used if the assumptions of normal distribution are met; otherwise, the Kruskal-Wallis test and the Bonferroni correction (post-hoc test) will be applied. The significance level will be set at p<0.05.

• Study Type: Interventional
• Enrollment (Estimated): 30
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Gözde ARICA, MSc; Phone Number: +905318893236; Email: gozde.arica@yalova.edu.tr
• Study Contact Backup: Name: Büşra KAYABINAR, PhD; Phone Number: +905553156871; Email: busra.kayabinar@yalova.edu.tr

Study Locations

• Turkey (Türkiye)
  • Yalova
    • Yalova, Yalova, Turkey (Türkiye)
      • Recruiting
      • Yalova University
      • Contact: Gözde ARICA, MSc; Phone Number: 05318893236; Email: gozde.arica@yalova.edu.tr
      • Sub-Investigator: Gözde ARICA, MSc
      • Contact: Büşra KAYABINAR, PhD; Phone Number: +905553156871; Email: busra.kayabinar@yalova.edu.tr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Age of 18-24 years
• Fagerström Nicotine Dependence Questionnaire score ≥4
• Smoking for at least 2 years
• Daily smoking ≥5 cigarettes and at least 90 pack-years. Stable condition (no acute respiratory infection in the last 4 weeks).
• FEV1 ≥80%
• Voluntary participation in the study
• No orthopedic or neurological problems that would prevent participation in exercise

Exclusion Criteria:

• Cardiac event or lung surgery in the last 6 months
• Respiratory problems such as COPD, asthma
• Orthopedic and neurological problems
• Termination of volunteering

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Chest PNF Techniques Group; Chest PNF exercises will be performed in supine, side, and prone positions. Each technique will be performed 12 times.	Other: Chest PNF Techniques Group; The combined isotonic contraction technique will be used to improve respiratory control. In all positions, the patient is asked to exhale first. Pressure and stretching are applied in the opposite direction of the movement. As the patient inhales, resistance is controlled. Supine position: Both hands are placed on the sternum and oblique downward pressure is applied. The hands are placed parallel and diagonally along the lateral chest wall, above the lower ribs. To focus on the upper chest region, the hands are similarly placed on the pectoral muscles. Side-lying position: Both hands are placed parallel and diagonally along the lateral chest wall above the lower ribs. This position is beneficial to resist chest movement in the lower region and thus distribute the force to chest movement in the upper region. Prone position: The hands are placed parallel and diagonally along the lower ribs. In the forearm position, one hand is placed on the sternum and the other on the intercostal region
Experimental: Chest Mobility Exercises Group; Chest mobility exercises will be performed. The exercises will be done in combination with diaphragmatic breathing exercises, consisting of 18-20 repetitions with 30-second breaks.	Other: Chest Mobility Exercises Group; Chest rotation, Passive lateral flexion while lying on the side, Mobilization of the thoracic facet joint while lying on the back, Trunk rotation in sitting position, Moving the arm in front of the chest while sitting, Cat-camel exercise, Pectoral stretch, Chest mobility in crawling position.
No Intervention: Control; No action will be taken.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Dyspnea Assessment	Modified Medical Research Council -mMRC: The mMRC used for dyspnea assessment consists of five stages. Stage 0 represents mild dyspnea, and Stage 4 represents severe dyspnea (Bestall et al., 1999).	Baseline and through study completion, an average of 6 weeks
Pulmonary Function Testing	Measurements are taken with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) while the patient is in a seated position. Forced expiratory volume in one second (FEV1) is measured (Miller et al., 2005).	Baseline and through study completion, an average of 6 weeks
Pulmonary Function Testing	Measurements are taken with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) while the patient is in a seated position. Forced vital capacity (FVC) is measured (Miller et al., 2005).	Baseline and through study completion, an average of 6 weeks
Pulmonary Function Testing	Measurements are taken with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) while the patient is in a seated position. The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is measured (Miller et al., 2005).	Baseline and through study completion, an average of 6 weeks
Pulmonary Function Testing	Measurements are made with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) with the patient in a sitting position. Peak expiratory flow rate (PEF) are measured (Miller et al., 2005).	Baseline and through study completion, an average of 6 weeks
Pulmonary Function Testing	Measurements are made with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) with the patient in a sitting position. Flow rate at 25-75% of forced vital capacity (FEF 25-75%) are measured (Miller et al., 2005)	Baseline and through study completion, an average of 6 weeks
Pulmonary Function Testing	Measurements are made with a portable spirometer (Cosmed Pony FX, Cosmed, Rome, Italy) with the patient in a sitting position. Vital capacity (VC) are measured (Miller et al., 2005).	Baseline and through study completion, an average of 6 weeks
Respiratory Muscle Strength Measurement	Maximal inspiratory pressure measurements (MIP) will be taken. For the MIP measurement, the participant sits in a chair and, with a nose clip attached, is asked to take a maximum inspiration through the mouth for 1-3 seconds (Neder et al., 1999)	Baseline and through study completion, an average of 6 weeks
Respiratory Muscle Strength Measurement	Maximal expiratory pressure measurements (MEP) will be taken. For the MEP measurement, the participant is asked to take a maximum inspiration and then a maximum expiration for 1-3 seconds. After performing both measurements three times, the best reading is recorded (Neder et al., 1999).	Baseline and through study completion, an average of 6 weeks
Exercise Capacity Assessment	Six-Minute Walk Test - 6MWT: The six-minute walk test is one of the most frequently used field tests in clinical settings due to its practicality and low cost, assessing submaximal functional capacity. The test is conducted in a 30-meter corridor. After being informed about the test, the participant is asked to walk in a marked area in the corridor for six minutes, and the total distance is recorded. It is recommended that it be performed three times at regular intervals throughout the day, and the best distance recorded. The patient may stop and rest at any time and use assistive devices if available. Blood pressure, heart rate, oxygen saturation, fatigue, and dyspnea are measured before and after the test. In individuals with COPD, a walk of <350 meters is associated with lower exercise capacity and increased mortality risk (Ceylan, 2014). A 6-minute walk will result in a report calculating the total distance walked in meters.	Baseline and through study completion, an average of 6 weeks
Depression Assessment (Beck Depression Inventory-BDI)	The BDI is a scale used to assess depression. It consists of 21 items, each with four options. The scale has a scoring system of 0-3. The lowest score a participant can receive on this scale is 0 and the highest is 63. Higher scores indicate increasing levels of depression. Total scores are divided into 4 groups: 0-9 points: "minimal depression," 10-16 points: "mild depression," 17-29 points: "moderate depression," and 30 points and above: "severe depression." The Turkish reliability study of this scale was conducted by Hisli in 1988 (Hisli, 1989).	Baseline and through study completion, an average of 6 weeks
Physical Activity Level Assessment	Short Form of the International Physical Activity Questionnaire-IPAQ-SF: This questionnaire, whose validity and reliability in Turkish were developed by Sağlam et al., consists of 7 questions. It asks about vigorous and moderate physical activities, including walking and sitting activities, performed within the last week, on how many days per week and for how long. Sitting activity is not included in the scoring section (Sağlam et al., 2010). MET values of the activities were used as 8 METs for vigorous physical activities, 4 METs for moderate physical activities, and 3.3 METs for walking, and the total score was recorded as MET-min/week. The total duration (minutes) and frequency (days) of each are required for score calculation. The MET score is obtained by multiplying the MET value of the activity by the number of days and minutes. The results are evaluated in three categories: inactive, moderately active, and active: Inactive, Moderately active, Active (Craig et al., 2003).	Baseline and through study completion, an average of 6 weeks
Quality of Life Assessment	Patients' quality of life will be assessed using the Short Form-36 (SF-36). It consists of eight sub-items: physical function, social function, role limitations due to physical problems, pain, vitality, mental health, and general health perception. Each sub-item is scored between 0 and 100, and these scores are not added together. A high score indicates good health. The Turkish validity and reliability study of the scale was conducted by Demiral et al. (Demiral et al., 2006).	Baseline and through study completion, an average of 6 weeks
Chest Expansion Measurement	Chest expansion was assessed by measuring the circumference of the chest wall at maximum inspiration and maximum expiration. Measurements were taken with a measuring tape at the axillary (level of the 4th rib), epigastric (level of the xiphoid process), and subcostal (above the 11th and 12th ribs) levels while the person was in an upright sitting position. Participants were asked to perform maximum inspiration and expiration, and the difference between the two was recorded in centimeters. Each measurement was repeated three times for each of the three regions (Otman and Köse, 2014).	Baseline and through study completion, an average of 6 weeks
Fatigue Assessment	Patients' fatigue was assessed using the Turkish adaptation of the Fatigue Severity Scale (Appendix-6). The scale consists of 9 questions, and patients were asked to indicate their response using a number from 1 to 7, with 1 indicating complete disagreement and 7 indicating complete agreement. The possible score range for the questionnaire is 9-63 (Gencay-Can and Can, 2012; Armutlu et al., 2007).	Baseline and through study completion, an average of 6 weeks
Harvard Step Test	This test, used to measure cardiopulmonary endurance and physical fitness, involves individuals climbing and descending steps for 5 minutes. During ascent and descent, the feet must switch positions and remain side-by-side. Heart rate and oxygen levels are measured before and after the test. Heart rate is measured at 1, 2, and 3 minutes after the test ends. The result is calculated as: (Test duration (seconds) x 100) / (Sum of 2 x recovery heart rates) (Mackenzie, 2005). Results are scored as follows: 90 and above excellent, 80-89 good, 65-79 moderate, 55-64 poor, and 54 and below very poor (Babu et al., 2015).	Baseline and through study completion, an average of 6 weeks

Collaborators and Investigators

• Sponsor: University of Yalova
• Investigators: Principal Investigator: Büşra KAYABINAR, PhD, University of Yalova

Publications and helpful links

General Publications

• Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005 Aug;26(2):319-38. doi: 10.1183/09031936.05.00034805. No abstract available.
• Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB.
• Neder JA, Andreoni S, Lerario MC, Nery LE. Reference values for lung function tests. II. Maximal respiratory pressures and voluntary ventilation. Braz J Med Biol Res. 1999 Jun;32(6):719-27. doi: 10.1590/s0100-879x1999000600007.
• Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available.
• Sahin F, Yilmaz F, Ozmaden A, Kotevolu N, Sahin T, Kuran B. Reliability and validity of the Turkish version of the Berg Balance Scale. J Geriatr Phys Ther. 2008;31(1):32-7. doi: 10.1519/00139143-200831010-00006.
• Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA. Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999 Jul;54(7):581-6. doi: 10.1136/thx.54.7.581.
• Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O'Donnell DE; American Thoracic Society Committee on Dyspnea. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012 Feb 15;185(4):435-52. doi: 10.1164/rccm.201111-2042ST.
• Mong Y, Teo TW, Ng SS. 5-repetition sit-to-stand test in subjects with chronic stroke: reliability and validity. Arch Phys Med Rehabil. 2010 Mar;91(3):407-13. doi: 10.1016/j.apmr.2009.10.030.
• Gungen C, Ertan T, Eker E, Yasar R, Engin F. [Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg. 2002 Winter;13(4):273-81. Turkish.
• Yorgancioglu A, Polatli M, Aydemir O, Yilmaz Demirci N, Kirkil G, Nayci Atis S, Kokturk N, Uysal A, Akdemir SE, Ozgur ES, Gunakan G. [Reliability and validity of Turkish version of COPD assessment test]. Tuberk Toraks. 2012;60(4):314-20. doi: 10.5578/tt.4321. Turkish.
• Polatli M, Yorgancioglu A, Aydemir O, Yilmaz Demirci N, Kirkil G, Atis Nayci S, Kokturk N, Uysal A, Akdemir SE, Ozgur ES, Gunakan G. [Validity and reliability of Turkish version of St. George's respiratory questionnaire]. Tuberk Toraks. 2013;61(2):81-7. doi: 10.5578/tt.5404. Turkish.
• Beaumont M, Mialon P, Le Ber C, Le Mevel P, Peran L, Meurisse O, Morelot-Panzini C, Dion A, Couturaud F. Effects of inspiratory muscle training on dyspnoea in severe COPD patients during pulmonary rehabilitation: controlled randomised trial. Eur Respir J. 2018 Jan 25;51(1):1701107. doi: 10.1183/13993003.01107-2017. Print 2018 Jan.
• Tredgett MW, Davis TR. Rapid repeat testing of grip strength for detection of faked hand weakness. J Hand Surg Br. 2000 Aug;25(4):372-5. doi: 10.1054/jhsb.2000.0433.
• Li Z, Liu S, Wang L, Smith L. Mind-Body Exercise for Anxiety and Depression in COPD Patients: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019 Dec 18;17(1):22. doi: 10.3390/ijerph17010022.
• Ceylan, E. (2014). Kardiyopulmoner egzersiz testleri. Journal of Clinical and Experimental Investigations, 5(3), 504-509.
• Han B, Chen Z, Ruan B, Chen Y, Lv Y, Li C, Yu L. Effects of Inspiratory Muscle Training in People with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Life (Basel). 2024 Nov 12;14(11):1470. doi: 10.3390/life14111470.
• Ammous O, Feki W, Lotfi T, Khamis AM, Gosselink R, Rebai A, Kammoun S. Inspiratory muscle training, with or without concomitant pulmonary rehabilitation, for chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev. 2023 Jan 6;1(1):CD013778. doi: 10.1002/14651858.CD013778.pub2.
• Ekren, P. K., Gürgün, A. 2013. "KOAH'da pulmoner rehabilitasyon: kime, ne zaman, nasıl", Güncel Göğüs Hastalıkları Serisi, 1(1), 124-35.
• Firat, M., Saglam, M., Calik-Kutukcu, E., Inal-Ince, D., Ardali-Duzgun, S., Yildirim, T., Vardar-Yagli, N. 2024. Effect of functional inspiratory muscle training in chronic kidney disease", Eur Respir J, 64, 68.
• Gezgen, A., Erk, M., Müsellim, B., Demir, T., Mutlu, B. 2001. "KOAH'da Üst Ekstremite Egzersizlerinin Yaşam Kalitesine ve Solunum Fonksiyonlarına Etkisi", Solunum Dergisi, 3, 60-65.
• Global Initiative For Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Revised 2011.
• Gökçek, Ö., Doğru Hüzmeli, E., Katayıfçı, N. 2019. "Kronik obstrüktif akciğer hastalarında dispnenin yaşam kalitesi ve depresyona etkisi", ACU Sağlık Bil Dergisi, 10(1), 84-88.
• Huzmeli I, Katayifci N, Abay B, Akkus O, Ozer AY. The effectiveness of functional inspiratory muscle training on exercise capacity and peripheral muscle strength in patients with essential hypertension: a three-arm randomized controlled trial. BMC Sports Sci Med Rehabil. 2025 Feb 28;17(1):29. doi: 10.1186/s13102-025-01082-w.
• Keskin, T., Başkurt, Z. 2021. "KOAH Tanılı Yaşlı Bireylerde Pulmoner Rehabilitasyon", Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 8(1), 157-161.
• McConnell, A. 2013. Respiratory Muscle Training, Theory and Practice, Edinburg: Elsevier.
• Özdemir, F., Koca, T., Berber, N., Şahin, Ş. 2018. "Astım ve KOAH Hastalarının Fiziksel Aktivite Düzeylerinin Değerlendirilmesi", KSÜ Tıp Fakültesi Dergisi, 14(1), 20-23.
• Ozsoy I, Kahraman BO, Ozsoy G, Ilcin N, Tekin N, Savci S. Effects of an Integrated Exercise Program Including "Functional" Inspiratory Muscle Training in Geriatric Individuals with and without Chronic Obstructive Pulmonary Disease. Ann Geriatr Med Res. 2021 Mar;25(1):45-54. doi: 10.4235/agmr.21.0014. Epub 2021 Mar 30.
• Özyılmaz, S., Gürses, H. N. 2012. "KOAH'ta Göğüs Fizyoterapisi". KOAH'ta pulmoner rehabilitasyon. Editörler: Gürses HN, Biber Ç. TÜSAD Eğitim Kitapları Serisi. İstanbul: Probiz Ltd Şti.
• Pesci A, Balbi B, Majori M, Cacciani G, Bertacco S, Alciato P, Donner CF. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J. 1998 Aug;12(2):380-6. doi: 10.1183/09031936.98.12020380.
• Saetta M, Di Stefano A, Maestrelli P, Ferraresso A, Drigo R, Potena A, Ciaccia A, Fabbri LM. Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis. 1993 Feb;147(2):301-6. doi: 10.1164/ajrccm/147.2.301.
• Şahin, H., Pehlivan, E. 2022. "KOAH'da Pulmoner Rehabilitasyon". Kronik Obstrüktif Akciğer Hastalığı (KOAH). Ankara: Dünya Tıp Kitapevi.
• Saka S, Gurses HN, Bayram M. Effect of inspiratory muscle training on dyspnea-related kinesiophobia in chronic obstructive pulmonary disease: A randomized controlled trial. Complement Ther Clin Pract. 2021 Aug;44:101418. doi: 10.1016/j.ctcp.2021.101418. Epub 2021 May 14.
• Troosters T, Janssens W, Demeyer H, Rabinovich RA. Pulmonary rehabilitation and physical interventions. Eur Respir Rev. 2023 Jun 7;32(168):220222. doi: 10.1183/16000617.0222-2022. Print 2023 Jun 30.
• Tütüneken, YE. (2024), "Kronik İnmeli Hastalarda İnspiratuar Kas Eğitimine Karşı Fonksiyonel İnspiratuar Kas Eğitiminin Gövde Kontrolüne ve Solunum Fonksiyonlarına Etkisi''
• Yüksel, E. G., Ursavaş, A., Irdesel, J., Koç, M., Uzaslan, E. K., Güneş, S., Özyardimci, N. 2005. "Kronik Obstrüktif Akciğer Hastaliğinda Multidisipliner Pulmoner Rehabilitasyon Programinin Etkinliği", Turkiye Klinikleri Archives of Lung, 6(3), 115-119.
• de Paula Lima PO, de Oliveira RR, Costa LO, Laurentino GE. Measurement properties of the pressure biofeedback unit in the evaluation of transversus abdominis muscle activity: a systematic review. Physiotherapy. 2011 Jun;97(2):100-6. doi: 10.1016/j.physio.2010.08.004. Epub 2010 Oct 23.
• HİSLİ, N. (1989). "Beck Depresyon Envanterinin üniversite öğrencileri için geçerliği, güvenirliği", Psikoloji dergisi, cilt 7, sayi 23, ss. 3-13.
• Saka S, Savci S, Kutukcu EC, Saglam M, Yagli NV, Ince DI, Guclu MB, Ozalp O, Arikan H, Karakaya G, Coplu L. Validity and Reliability of the Turkish Version of the London Chest Activity of Daily Living Scale in Obstructive Lung Diseases. Turk Thorac J. 2020 Mar 1;21(2):116-121. doi: 10.5152/TurkThoracJ.2019.18155. Print 2020 Mar.
• Janaudis-Ferreira T, Beauchamp MK, Robles PG, Goldstein RS, Brooks D. Measurement of activities of daily living in patients with COPD: a systematic review. Chest. 2014 Feb;145(2):253-271. doi: 10.1378/chest.13-0016.
• Revicki DA, Meads DM, McKenna SP, Gale R, Glendenning GA, Pokrzywinski MHA. COPD and asthma fatigue scale (CAFS): development and psychometric assessment. Health Outcomes Res Med 2010; 1(1): 5-16.
• Kisner, C., Colby, L. A., & Borstad, J. (2017). Therapeutic exercise: foundations and techniques. Fa Davis.
• Ergün, P. 2019. "Pulmoner rehabilitasyon güncel yaklaşımlar" Güncel Göğüs Hastalıkları Serisi, 7, 7-18
• İnce, D., Savcı, S., Sağlam, M., Arıkan, H., Çöplü, L. 2011. "Kronik obstrüktif akciğer hastalarında sigara öyküsü ve fonksiyonel kapasite arasındaki ilişki", Fizyoterapi Rehabilitasyon, 22(1), 39-43.

Study record dates

Study Major Dates

• Study Start (Actual): March 9, 2026
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): December 31, 2026

Study Registration Dates

• First Submitted: March 17, 2026
• First Submitted That Met QC Criteria: March 17, 2026
• First Posted (Actual): March 23, 2026

Study Record Updates

• Last Update Posted (Actual): March 25, 2026
• Last Update Submitted That Met QC Criteria: March 22, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: Exercise; Smokers; Proprioceptive Neuromuscular Facilitation (PNF) Stretching
• Additional Relevant MeSH Terms: Behavior; Motor Activity; Smoking
• Other Study ID Numbers: 2025/552

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No