Sensory and Connectivity Abnormalities in Autism Spectrum Disorders

Inclusion Criteria:

• All of the following criteria must be met by all participants:

  • The participant or the participant's legal guardian is able to understand and is willing to comply with the requirements of the study
  • The participant meets the age requirements (14-32 years old)
  • The participant or legal guardian has signed an Informed Consent Form specific to this study, and is able to understand the consent form.
  • The participant must have English as their first language.
  • The participant must have a non-verbal IQ > 70

• For the ASD/language disorder group only:

  • Autism Spectrum Disorder: Participants must meet criteria for Autism Spectrum Disorder on the ADOS.

Exclusion Criteria:

• The following exclusion criteria apply to both control and autism groups:

  • Any volunteer for whom informed consent cannot be obtained
  • Volunteers with metal braces, extensive dental work involving metals, implanted electromagnetically activated medical equipment (cardiac pacemakers, neurostimulators, functioning infusion pumps), all of which would interfere with the MEG signal, will be excluded from the MEG portion of the study
  • Volunteers with any medically diagnosed sensory loss
  • Volunteers with a known genetic disorder (e.g. Tourette's syndrome, etc), or other medical condition affecting the brain, such as progressive encephalopathy as well as those who are on high doses of multiple anti-seizure medications and have frequent, uncontrolled seizures
  • Asphyxia at birth or any other time, premature birth (Fewer than 34 weeks gestation)

• For the control group only:

  • Volunteers diagnosed with a mental condition such as depression, anxiety, aggression, hyperactivity, attention deficit disorder (with or without hyperactivity).
  • Volunteers who score below the autism spectrum cut-off (in the normal range) on the ADOS and SCQ
  • Volunteers on any sort of neuro-psychopharmacological treatment (including antidepressants, stimulants, antipsychotics, anticonvulsants, benzodiazepines).

• For the autism group only:

  • Children or adults not meeting criteria for autism spectrum disorder
  • Volunteers with co-morbid disorders such as tuberous sclerosis or fragile X.