Stability of rTMS on Cognition and Brain Networks on Healthy Subjects.

Inclusion Criteria:

• Healthy male subjects aged between 18 and 40 years-old inclusive.
• Education level: at least secondary.
• Right-handed (Edinburgh Handedness Inventory).
• The subjects are in good health on the basis of the medical interview (medical history, symptoms), the physical examination and vital signs.
• No history of psychiatric disorders (assessed by Structured Clinical Interview for DSM IV Disorders (SCID) for Barcelona and by the Mini International Neuropsychiatric Interview (MINI) for Marseille).
• No history of neurological disorders
• No history of concussion (cranial or facial trauma) without or with loss of consciousness.
• Subject without history of brain disease (severe brain trauma, stroke, cerebral tumor...).
• Subject without lesion on MRI.
• Subject without abnormal electrical activities on standard clinical EEG.
• No history of drug or alcohol abuse.
• No smoker or ≤ 5 cg/ day.
• The subject can complete the neuropsychological test battery during the training session.
• Subject without contraindication to MRI.
• The subject is able to read and understand the Information Form and comply with the protocol instructions and restrictions.
• The subject is covered by a social insurance.
• The subject has provided written informed consent.

Exclusion Criteria:

• History or presence of psychiatric illness (Psychiatric interview).
• History or presence of neurologic illness.
• The subject, in the opinion of the investigator, is unlikely to comply with the study protocol or is unsuitable for any other reason.
• The subject participates in another clinical trial or is still being within a washout period of 1 month since last taking of a previous clinical trial, or subjects who have received more than 4500 Euros in the previous 12 months for participating in clinical trials.
• Presence of metallic objects within the body.
• Subjects with pacemaker.
• Claustrophobia.
• Individual and familial history of epileptic seizure.
• Any medication listed (see annexe) in the safety guidelines published by the Safety of TMS Consensus Group (Rossi et al., 2009) will be forbidden.
• Subject with a correct hit rate during the retrieval session of the memory task