A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon (CArDiAX)

The feasibility of xenon application compared to sevoflurane application will be assessed by:

• The depth of anaesthesia level
• The peri-anaesthetic respiratory profile
• The peri-anaesthetic haemodynamic profile

The following safety parameters will be assessed:

• Doses and concentration of study treatments
• Trans-esophageal echocardiography
• Measures of renal function
• Intra-operative blood loss and amount of transfused blood/products
• Need for hemodynamic and inotropic support
• The patient's regional cerebral tissue oxygenation rSO2
• The incidence of AE and SAE

The following secondary efficacy parameters will be assessed:

• the patients organ function status
• The severity of postoperative critical illness
• The incidence of Post-operative Delirium (POD)
• The duration of postoperative intensive care unit and in-hospital stay

Secondary safety parameters:

• hemodynamic and respiratory profile, including vital signs
• incidence of major adverse cardiac and cerebral events (MACCE)
• laboratory parameters -post-operative pain
• further AE and SAE