Effects of Intravenous Anesthetics and Inhaled Anesthetics on Postoperative Sleep in Patients Undergoing Gynecologic Laparoscopic Surgery

The Effects of Intravenous Anesthetics and Inhaled Anesthetics on Patients' Postoperative Sleep

Sponsors

Lead sponsor: Yanchao Yang

Source Shengjing Hospital
Brief Summary

Surgery is a very common treatment in clinical practice. As an important part of surgery, anesthesia is a safe and comfortable pain-free surgical environment, and it is easy to leave sequelae and other negative effects. General anesthesia can lead to postoperative sleep rhythm disorder, and severe cases can develop postoperative operative sleep disturbances (PSD). Postoperative sleep disorders were associated with postoperative hemorrhagic hypoxemia, postoperative pain sensitization, postoperative cognitive dysfunction, and cardiovascular complications such as blood pressure fluctuations caused by sympathetic excitation. In addition, postoperative sleep disorders can increase the number of apneas in patients with sleep apnea, and hypoxemia caused by apnea is an independent risk factor for nocturnal acute myocardial infarction. Normal sleep is divided into non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM). The sleep characteristic of REM is the presence of rapid eye movement during sleep, which is less stable than NREM and is associated with dreaming and muscle movement. The sleep characteristic of NREM is deep sleep, also known as slow wave sleep. The study found that most intravenous anesthetics and inhaled anesthetics can directly stimulate GABAergic neurons in the Ventrolateral preoptic area (VLPO), and induce anesthesia through endogenous sleep-regulated neural circuits. Among them, the anesthesia induced by intravenous anesthetic propofol can not only replace NREM sleep, but also replace REM sleep; while inhaled anesthetics can not meet REM sleep, and the rebound of REM sleep increases later. Therefore, the choice of anesthetic drugs during surgery has positive significance for the adjustment of postoperative sleep conditions.

Overall Status Not yet recruiting
Start Date May 20, 2020
Completion Date December 1, 2020
Primary Completion Date December 1, 2020
Study Type Observational [Patient Registry]
Primary Outcome
Measure Time Frame
postoperative sleep quality of one night after surgery one night after the surgery
postoperative sleep quality of the third night after surgery the third night after surgery
Enrollment 160
Condition
Intervention

Intervention type: Drug

Intervention name: Propofol

Description: Group Propofol was given propofol 4mg/kg/h intravenous pumping to assist sedation

Arm group label: Group Propofol

Other name: Intravenous Anesthetics

Intervention type: Drug

Intervention name: Sevoflurane

Description: Group Sevoflurane was given sevoflurane inhalation maintenance (concentration of 2% to 3% and mixed with 50% oxygen and air) to assist sedation;

Arm group label: Group Sevoflurane

Other name: Inhaled Anesthetics

Eligibility

Sampling method: Probability Sample

Criteria:

Inclusion Criteria:

ASA : GradeⅠtoⅡ Laparoscopic gynecological surgery

Exclusion Criteria:

history of sleep apnea; severe neuropsychiatric disorders; long-term use of sedatives or sleeping pills; can not implement multi-lead sleep monitoring and other sleep disorders

Gender: Female

Minimum age: 18 Years

Maximum age: 60 Years

Overall Contact

Last name: Shiyi Li

Phone: 15942323832

Email: [email protected]

Verification Date

May 2020

Responsible Party

Responsible party type: Sponsor-Investigator

Investigator affiliation: Shengjing Hospital

Investigator full name: Yanchao Yang

Investigator title: Principal investigator

Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Group Propofol

Description: Group Propofol was given propofol 4mg/kg/h intravenous pumping to assist sedation, remifentanil 0.2μg/kg/min intravenous pumping assisted analgesia

Arm group label: Group Sevoflurane

Description: Group Sevoflurane was given sevoflurane inhalation maintenance (concentration of 2% to 3% and mixed with 50% oxygen and air) to assist sedation, remifentanil 0.2μg/kg/min intravenous pumping assisted analgesia

Study Design Info

Observational model: Cohort

Time perspective: Prospective

Source: ClinicalTrials.gov