- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT01775111
Influence of Strength Training and Protein Supplementation on Fitness of Institutionalized Elderly
Influence of Strength Training and Nutritional Supplementation on Physical Performance and Well-being of Older People in Pensioner Homes
The aim of this randomized, observer-blind, controlled intervention study with parallel groups is to study the effect of strength training (2x/week for 6 months) with and without additional dietary supplementation (protein-enriched) on muscle strength, function and mass, oxidative stress parameters and the immune system in elderly institutionalized persons.
The participants (n = 120) are recruited from Viennese senior residencies (Kuratorium Wiener Pensionistenwohnheime). After a pre-participation screening participants will be distributed randomly but stratified by sex and age to one of the 3 intervention groups (cognitive training, strength training, strength training + supplement).
Study participants are eligible if they are male or female with an age over 65 years and if their cognitive status as well as their physical fitness level allows to participate at the strength training sessions. Exclusion criteria comprise chronic diseases which contraindicate the medical training therapy, serious cardiovascular disease, diabetic retinopathy and manifest osteoporosis, medication with anticoagulants or cortisone drugs and also regular strength training during the last six months.
Primary outcome measure is the change in isokinetic torque of knee extensors. Secondary outcome measures comprise anthropometric data, functional performance tests, immunological and oxidative stress parameters. The change in muscle signaling pathways will be assessed from muscle biopsies.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Type d'étude
Inscription (Anticipé)
Phase
- N'est pas applicable
Contacts et emplacements
Coordonnées de l'étude
- Nom: Michael Quittan, Prim. Univ.Prof. Dr.
- Numéro de téléphone: 3401 +43160191
- E-mail: michael.quittan@wienkav.at
Sauvegarde des contacts de l'étude
- Nom: Barbara Wessner, Ass.-Prof. DI Dr.
- Numéro de téléphone: 28772 +4314277
- E-mail: barbara.wessner@univie.ac.at
Lieux d'étude
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Vienna, L'Autriche, 1150
- Recrutement
- University of Vienna, Centre of Sports Science and University Sports
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Contact:
- Barbara Wessner, Ass.-Prof. DI Dr.
- Numéro de téléphone: 28772 +4314277
- E-mail: barbara.wessner@univie.ac.at
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Chercheur principal:
- Barbara Wessner, Ass.-Prof. DI Dr.
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Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Adequate mental condition in order to follow the instructions and to perform the resistance exercise independently (Mini-Mental-State >23)
- Ability to walk 10 meters independently (without orthopaedic devices)
- 4 or more points at the Short Physical Performance Battery
Exclusion Criteria:
- Chronic diseases, which contraindicate a medical training therapy
- Serious cardiovascular diseases (congestive chronic heart failure, severe or symptomatic aortic stenosis, unstable angina pectoris, untreated arterial hypertension, cardiac arrhythmias)
- Diabetic retinopathy
- Manifest osteoporosis
- Regular use of cortisone-containing drugs
- Regular strength training (> 1x / week) in the last 6 months before inclusion
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Recherche sur les services de santé
- Répartition: Randomisé
- Modèle interventionnel: Affectation parallèle
- Masquage: Seul
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
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Comparateur factice: Cognitive Training
Cognitive Training (riddles, skill games, ...) is performed twice a week in small groups
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Expérimental: Strength Training
Progressive strength training is applied, meaning that the intensity is adjusted continuously in order to obtain a sufficient training stimulus.
Exercises are chosen to involve the major muscle groups and are performed by using the own body weight or elastic bands.
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Expérimental: Strength Training and Supplement
In addition to strength training as described above, participants receive a water-soluble dietary supplement 9x/week (FortiFit, Nutricia) consisting of 20.7 g of protein (56 En%, 19.7 g whey protein, 3 g leucine,> 10 g essential amino acids), 9.3 g carbohydrates (25 En%, 0.8 BE), 3.0 g fat (18 En%), 1.2 g fiber (2 En%), 800 IU (20μg) of vitamin D, 250mg calcium, vitamins B6 and B12, folic acid and magnesium.
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Délai |
---|---|
change from baseline in isokinetic torque of knee extensors
Délai: baseline and 6 months
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baseline and 6 months
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Mesures de résultats secondaires
Mesure des résultats |
Délai |
---|---|
change from baseline in 6min walking test
Délai: baseline and 6 months
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baseline and 6 months
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change from baseline in handgrip strength
Délai: baseline and 6 months
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baseline and 6 months
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change from baseline in single leg balance stand
Délai: baseline and 6 months
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baseline and 6 months
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change from baseline in lean body mass
Délai: baseline and 6 months
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baseline and 6 months
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change from baseline in muscular myostatin expression
Délai: baseline and 6 months
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baseline and 6 months
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change from baseline in DNA strand breaks
Délai: baseline and 6 months
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baseline and 6 months
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change from baseline in high-sensitive C reactive protein
Délai: baseline and 6 months
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baseline and 6 months
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Autres mesures de résultats
Mesure des résultats |
Délai |
---|---|
change from baseline in isokinetic torque of knee extensors at 12 months
Délai: baseline and 12 months
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baseline and 12 months
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change from baseline in isokinetic torque of knee extensors at 18 months
Délai: baseline and 18 months
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baseline and 18 months
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Collaborateurs et enquêteurs
Parrainer
Collaborateurs
Les enquêteurs
- Chercheur principal: Barbara Wessner, Ass.-Prof. DI Dr., University of Vienna
Publications et liens utiles
Publications générales
- Franzke B, Schober-Halper B, Hofmann M, Oesen S, Tosevska A, Henriksen T, Poulsen HE, Strasser EM, Wessner B, Wagner KH. Age and the effect of exercise, nutrition and cognitive training on oxidative stress - The Vienna Active Aging Study (VAAS), a randomized controlled trial. Free Radic Biol Med. 2018 Jun;121:69-77. doi: 10.1016/j.freeradbiomed.2018.04.565. Epub 2018 Apr 24.
- Tosevska A, Franzke B, Hofmann M, Vierheilig I, Schober-Halper B, Oesen S, Neubauer O, Wessner B, Wagner KH. Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial. Sci Rep. 2016 Dec 1;6:38084. doi: 10.1038/srep38084.
- Grimpampi E, Oesen S, Halper B, Hofmann M, Wessner B, Mazza C. Reliability of gait variability assessment in older individuals during a six-minute walk test. J Biomech. 2015 Nov 26;48(15):4185-4189. doi: 10.1016/j.jbiomech.2015.10.008. Epub 2015 Oct 20.
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude
Achèvement primaire (Anticipé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Autres numéros d'identification d'étude
- ActiveAgeing
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