- ICH GCP
- Registre américain des essais cliniques
- Essai clinique NCT02461914
Evaluate the Pharmacokinetics of Warfarin When Coadministered With PEX168 in Healthy Adult Subjects
An Open-label,Sequential,Single-site Study to Evaluate the Pharmacokinetics of Warfarin When Coadministered With Polyethylene Glycol Loxenatide (PEX168) in Healthy Adult Subjects
To assess the effect of PEX168 doses on the pharmacokinetics of warfarin in healthy subjects.To provide a scientific basis for clinical drug combination of PEX168.
To evaluated the impact of pharmacodynamics coadministrated hypodermic PEX168 and warfarin in healthy subjects.
To assess the safety of single doses of warfarin administered with and without PEX168
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
This was an open-label, sequential, single-center study that evaluated the pharmacokinetics of warfarin when coadministered with PEX168 in healthy adult subjects. The total duration of each subject's participation in the study was approximately 13 weeks, which included up to a 14-day Screening Period, a 51-day Treatment Period, and an approximately 4-week Follow-up Period.
Center: This study was conducted at a single site in the first affiliate hospital of Zhejiang University.All subjects receives a single 5mg oral dose of warfarin on Day 1 followed by 5 weekly 200μg doses of PEX168 injected subcutaneously beginning on Day 8 and a second single 5mg oral dose of warfarin on Day 44.
Type d'étude
Inscription (Réel)
Phase
- La phase 1
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Healthy male aged 18 to 45 years (including both ends) at the time of signing the informed consent.
- Weighing not less than 50kg,Body Mass Index (BMI)of 18 to 25kg/m2. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (Tbil) are within the normal range during screening;
- Estimated creatinine clearance (Clcr) ≥90ml / min calculated by the Cockcroft-Gault (CG) formula ;
- Capable of giving written informed consent, which included compliance with the requirements and restrictions listed in the consent form.
Exclusion Criteria:
- The hepatitis B surface antigen, hepatitis C antibody, HIV antibody test positive;
- Having history of syncope, palpitations, bradycardia, tachycardia and other anomalies, or via a comprehensive physical examination , routine laboratory tests (blood count, blood biochemistry, urine, etc.), 12-lead ECG, abdominal B ultrasound, and other abnormalities and clinical significance persons before screening;
- Having Alcohol and drug abuse within first 6 months before screening;
- Smoked within 3 months before screening;
- In screening period, blood pressure greater than 140 / 90mmHg, retest after diagnosis or pulse rate is higher than 100bpm person;
- In screening period, ECG QTc> 450ms,diagnosed after retest;
- Having a history of drug or allergic reactions or allergic constitution have hypersensitivity to any of the following:
1) Warfarin and / or any of its ingredients or other similar drugs . 2) PEX168
8. Before screening, having a history of cardiovascular disease or a history of pulmonary disease ;
9. The history of thromboembolic disease or undergoing surgery or gastrointestinal bleeding within 6 months before screening, or excessive bleeding or a history of heparin-induced thrombocytopenia have significant bleeding history or family history;
10.In screening period,platelet count or international normalized ratio (INR) or activated partial thromboplastin time (APTT) greater than the upper limit of the normal range or fibrinogen is less than the lower limit of the normal range;
11. In screening period , fasting triglycerides test result was greater than the upper limit of normal range;
12. Currently there is a history of liver disease or liver disease or a known hepatobiliary abnormalities (except asymptomatic gallstones);
13. Participate in blood donation and donation amount ≥400ml within three months before screening;
14. In screening period, having thyroid dysfunction or a history;
15. The history of gastrointestinal surgery before screening;
16. The history of pancreatitis;
17. History of cholecystitis gallbladder disease or other disease history;
18. The history of inflammatory bowel disease or a history of irritable bowel syndrome;
19. The history of Type 2 multiple endocrine neoplasia;
20. The history of medullary thyroid cancer;
21. The family has type 2 multiple endocrine fibromatosis or a history of medullary thyroid cancer;
22. Three months before screening, participated in any drug or medical device trials are (including placebo);
23. Using any of the tested drugs may affect prescription drugs , non-prescription drugs, herbal (especially ginseng, oral hypoglycemic agents) or multivitamin supplements persons;
24. Drinking medication or caffeine-containing xanthine food and beverage (listed in annex 3), strenuous exercise, or other effects of drug absorption, distribution, metabolism, excretion and other factors 2 days before screening.
25. Received GLP-1 analogs (e.g. exenatide) treatment;
26. Reluctant to take an effective method of contraception during the test;
27. Researchers believe any situation that might lead to any subject cannot complete the study or to the subject of this study bring significant risk.
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Autre
- Répartition: N / A
- Modèle interventionnel: Affectation à un seul groupe
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
---|---|
Expérimental: Warfaring and PEX168(200µg)
Warfarin: 5mg, oral Administration.
PEX 168: 200µg,injected subcutaneously,once a week.
|
200µg,injecté par voie sous-cutanée,une fois par semaine.
Autres noms:
5mg,oral,two times.
Autres noms:
|
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
---|---|---|
Composite measure the plasma concentrations of warfarin
Délai: Baseline to Day51
|
Plasma concentrations of warfarin, and to calculate the pharmacokinetic parameters: Tmax、Cmax、AUC0-t、AUC0-∞、λz ,t1/2、Vd/F、CL/F etc.
|
Baseline to Day51
|
Mesures de résultats secondaires
Mesure des résultats |
Délai |
---|---|
Incidence of adverse events and serious adverse events
Délai: Baseline to Day78
|
Baseline to Day78
|
Collaborateurs et enquêteurs
Parrainer
Les enquêteurs
- Chercheur principal: Jianzhong Shentu, MD, The first affiliate of Zhejiang University
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Réel)
Achèvement de l'étude (Réel)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Estimation)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Mots clés
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- PEX168-Ii
Plan pour les données individuelles des participants (IPD)
Prévoyez-vous de partager les données individuelles des participants (DPI) ?
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Essais cliniques sur En bonne santé
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AstraZenecaParexelComplété
Essais cliniques sur PEX168
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Jiangsu Hansoh Pharmaceutical Co., Ltd.Inconnue
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Jiangsu Hansoh Pharmaceutical Co., Ltd.Inconnue
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Jiangsu HengRui Medicine Co., Ltd.Beijing Tongren HospitalComplété
-
Jiangsu HengRui Medicine Co., Ltd.People's Liberation Army General Hospital of Chengdu Military RegionComplété
-
Jiangsu Hansoh Pharmaceutical Co., Ltd.Inconnue
-
Jiangsu HengRui Medicine Co., Ltd.China-Japan Friendship HospitalComplété
-
First Affiliated Hospital Xi'an Jiaotong UniversityComplété
-
Jiangsu Hansoh Pharmaceutical Co., Ltd.Complété
-
Jiangsu Hansoh Pharmaceutical Co., Ltd.Complété
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Fudan UniversityRecrutementObésité | Hyperplasie endométriale atypique | Problèmes de fertilitéChine