Variabilità nei test dei pasti misti: fissa o adattata alla dose calorica del fabbisogno energetico
Background:
Researchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on how to decide the number of calories to give in each meal. Some use fixed meals, which are the same size for everyone, and some use adjusted meals, based on the size of the person s body. Researchers want to know which MMTT is best to use for future research.
Objective:
To learn how fixed vs adjusted meals affect blood glucose levels in healthy people.
Eligibility:
Healthy people aged 18 years or older.
Design:
Participants will have 3 or 4 clinic visits of up to 8 hours in 8 weeks.
Participants will have baseline tests:
Their height, weight, and waist size will be measured.
They will have an oral glucose tolerance test: A needle attached to a tube (IV) will be inserted into a vein in the arm. They will have a sugary drink. Blood samples will be taken from the tube at intervals up to 3 hours after the drink.
They will have a body scan.
Participants will have 2 MMTT visits. One will include a fixed meal and one will include an adjusted meal. They will have tests at both visits:
Resting metabolic rate: A clear hood will be placed over the participant s head while they rest for 20 minutes. This will measure the oxygen they breathe in and out.
MMTT. Participants will have 5 minutes to drink a liquid meal. Blood samples will be taken at intervals for the next 4 hours....
Panoramica dello studio
Stato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
Study Description:
This study will be an outpatient study completed in 3-4 separate visits. We will compare two methods of dosing (fixed and adjusted) a mixed meal tolerance test (MMTT) to determine which results in greater physiological variability in hormone response. Ultimately, the goal is to determine which method of dosing is more appropriate in a research setting.
Objectives:
Primary Objective:
To determine whether an adjusted energy dose MMTT or a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs.
Secondary Objectives:
To determine whether baseline body composition, blood parameters (lipids, hormones, etc), and resting metabolic rate are associated with MMTT responses and whether this association is moderated by MMTT condition (fixed vs. adjusted).
Endpoints:
Primary Endpoint: Glucose area under the curve (AUC)
Secondary Endpoints: Area under the curve (AUC), incremental area under the curve (iAUC), value and timing of the absolute maximum (peak), value and timing of the inflection point after the absolute maximum value, value and timing of the maximum rate of incline, value and timing of the maximum rate of decline, total number of critical points with body composition, blood parameters, and resting metabolic rate as predictors.
Tipo di studio
Iscrizione (Stimato)
Fase
- Non applicabile
Contatti e Sedi
Contatto studio
- Nome: Susanne M Votruba, Ph.D.
- Numero di telefono: (602) 200-5336
- Email: votrubas@mail.nih.gov
Luoghi di studio
-
-
Arizona
-
Phoenix, Arizona, Stati Uniti, 85014
- Reclutamento
- NIDDK, Phoenix
-
Contatto:
- Susi Votruba, Ph.D.
- Numero di telefono: 602-200-5336
- Email: votrubas@niddk.nih.gov
-
-
Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Descrizione
- INCLUSION CRITERIA:
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Provision of signed and dated informed consent form.
- Agreement to adhere to Lifestyle Considerations throughout study duration.
- Males and females; Age >= 18years
- Healthy, as determined by medical history, physical examination, and laboratory tests.
EXCLUSION CRITERIA:
An individual who meets any of the following criteria will be excluded from participation in this
study:
- Current use of medications, dietary supplements, or alternative therapies known to alter energy metabolism.
- Fasting plasma glucose >= 126 mg/dL
- Type I or Type II Diabetes Mellitus by self-report.
- Hematologic disorders including significant anemia (male hemoglobin < 13.0 g/dL or female hemoglobin < 11.0 g/dL)
- Current pregnancy, pregnancy within the past 6 months or currently lactating
- History or self-report of gastrointestinal disease, including inflammatory bowel diseases (e.g. Chron s disease and ulcerative colitis), malabsorption syndromes (e.g. celiac disease), gastric ulcer (active) which may alter metabolism or absorption of study food by self-report
- Evidence of alcohol abuse as defined by an 8-point score on the Alcohol consumption screening AUDIT questionnaire in adults.
- Participants who report taking large doses of acetaminophen (> 3 grams daily) who cannot stop acetaminophen 24 hours prior to and following the meal tests will be excluded from the study.
- Inability to consume provided food based on a food allergy or intolerance.
- Conditions not specifically mentioned above may serve as criteria for exclusion at the discretion of the investigators.
- Any disorder, unwillingness, or inability not covered by any other exclusion criteria which, in the investigator s and/or team s opinion, jeopardizes the safety of the participant or others or would interfere with adherence to the protocol (such as claustrophobia).
Conditions not specifically mentioned above may serve as criteria for exclusion at the discretion of the investigators.
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Scienza basilare
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione incrociata
- Mascheramento: Separare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Comparatore attivo: 1
Fixed Mixed Meal Test |
a FIXED dose meal that will be 900 kcal of a liquid meal |
|
Comparatore attivo: 2
Adjusted Mixed Meal Test |
a body weight ADJUSTED dose liquid meal. (30% of total daily energy requirements) |
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
To determine whether an adjusted energy dose MMTTor a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs.
Lasso di tempo: Baseline, Visit 3/4
|
Glucose AUC associated with MMTT conditions (fixed vs. adjusted). |
Baseline, Visit 3/4
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Body Composition
Lasso di tempo: Baseline, Visit 3/4
|
Change in energy expenditure associated with MMTT conditions (fixed vs. adjusted). |
Baseline, Visit 3/4
|
|
Resting Metabolic Rate
Lasso di tempo: Baseline, Visit 3/4
|
Change in energy expenditure associated with MMTT conditions (fixed vs. adjusted). |
Baseline, Visit 3/4
|
|
Lipids
Lasso di tempo: Baseline, Visit 3/4
|
Change in energy expenditure associated with MMTT conditions (fixed vs. adjusted). |
Baseline, Visit 3/4
|
Collaboratori e investigatori
Investigatori
- Investigatore principale: Susanne M Votruba, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pubblicazioni e link utili
Collegamenti utili
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Inizio studio (Effettivo)
Completamento primario (Stimato)
Completamento dello studio (Stimato)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Effettivo)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- 10001707
- 001707-DK
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