A Progressive Resistance Training Program in Patients With Haemophilia

실험적: Training group

Each subject will participate in 2 sessions each week during 8 weeks, with 3 days of difference (rest) between the sessions.

다른: Progressive resistance training

Progressive resistance training program

위약 비교기: Control group

Usual daily activities

다른: Normal daily activities

Usual daily activities

Change in Muscle strength

For measuring the isometric knee flexion and extension, ankle plantarflexion and dorsiflexion strength and isometric elbow flexion and extension strength, a portable hand-held dynamometer will be used (Nicholas Manual Muscle Tester, Lafayette Instruments, Indiana, USA).

Change in Timed Up and Go

The Timed Up and Go test (TUG) is a simple test used to assess a person's mobility and requires both static and dynamic balance.

It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down.

Change in Haemophilia Quality of life questionnaire (A36 Haemophilia-QoL® )

The Haemophilia-QoL questionnaire is a self-report modular instrument that assesses nine relevant HRQoL domains for patients with haemophilia (e.g. physical health, daily activities, joint damage, pain, treatment satisfaction, treatment difficulties, emotional functioning, mental health, relationships and social activity).

Change in Bleedings

Number of Bleedings During the study

Change in viscoelastic properties (rectus femoris)

Myoton Pro

Change in sit-to-stand test

The time taken for the participant to stand up and sit down from a standard 45 cm chair with arms three times, as quickly as possible, was measured.

Change in Haemophilia Activities List questionnaire

The Haemophilia Activities List questionnaire measures the impact of hemophilia on self-perceived functional abilities in adults.

It contains 42 multiple choice questions in seven domains:

Lying/sitting/kneeling/standing (8 items) Functions of the legs (9 items) Functions of the arms (4 items) Use of transportation (3 items) Self-care (5 items) Household tasks (6 items) Leisure activities and sports (7 items) The most important outcomes are the overall sum score and three component scores relating to upper extremity activities, basic lower extremity activities, and complex lower extremity activities. A domain score for each of the seven domains can also be calculated.

Change in The Haemophilia Joint Health Score (HJHS)

The HJHS measures joint health, in the domain of body structure and function (i.e. impairment), of the joints most commonly affected by bleeding in hemophilia: the knees, ankles, and elbows.The HJHS 2.1 provides a total score (higher score is worse; max=124), joint specific scores, and a global gait score.

Change in Pain

11-point numerical pain rating scale with higher score meaning higher pain

Change in workability index

workability index with single question

Change in analgesics use (days/week)

The number of days the participants used analgesics during the last week

Change in Range Of Motion (ROM)

elbow extensio/flexion, ankle dorsiflexion/plantar flexion and knee flexion/extension ROM with a goniometer

Change in Kinesiophobia

Tampa Scale of Kinesiophobia (TSK-11SV) used to assess changes in fear of movement