The Effect of Dexmedetomidine on Kidney Function in EVAR

The Effect of Dexmedetomidine on the Incidence of Acute Kidney Injury in EVAR

Sponsors

Hoofdsponsor: University of Thessaly

Bron University of Thessaly
Korte samenvatting

This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia

gedetailleerde beschrijving

This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.

Algemene status Not yet recruiting
Startdatum March 30, 2021
einddatum February 1, 2024
Primaire voltooiingsdatum November 30, 2023
Fase N/A
Studietype Interventional
Primaire uitkomst
Meten Tijdsspanne
Incidence of Acute Kidney Injury 1st Postoperative Day
Secundair resultaat
Meten Tijdsspanne
Incidence of postoperative ICU admission Operation day to 5th postoperative day
Incidence of arrhythmia Up to 24 hours after surgery
Incidence of Postoperative Delirium Operation day to 4th postoperative day
Inschrijving 200
Staat
Interventie

Type interventie: Drug

Interventienaam: Dexmedetomidine

Omschrijving: Administration of dexmedetomidine intraoperatively

Armgroeplabel: DEXMEDETOMIDINE AND AKI

Geschiktheid

Criteria:

Inclusion Criteria: - elective EVAR under general anesthesia - adult patients 18- 85 years old - American society of anesthesiologists (ASA) physical status I - IV Exclusion Criteria: - refusal to participate or sign the informed consent form - GFR < 50ml/mim - Bradyarrhythmia <50/min - Hemodynamic instability - Known allergy to Dexmedetomidine - Severe hepatic insufficiency

Geslacht: All

Minimum leeftijd: 18 Years

Maximale leeftijd: 85 Years

Gezonde vrijwilligers: No

Algemeen ambtenaar
Algemeen contact

Achternaam: Eleni Arnaoutoglou, MD, PhD

Telefoon: +306974301352

E-mail: [email protected]

Plaats
Faciliteit: Contact: Contact backup: Onderzoeker: Univeristy of Thessaly Eleni Arnaoutoglou, MD, PhD 2413501370 [email protected] Eleni Arnaoutoglou, MD, PhD Principal Investigator Metaxia Bareka, MD, PhD Sub-Investigator Konstantinos Stamoulis, MD, PhD Principal Investigator
Locatie Landen

Greece

Verificatiedatum

February 2021

Verantwoordelijke partij

Type: Principal Investigator

Aansluiting bij onderzoeker: University of Thessaly

Volledige naam van de onderzoeker: Elena Arnaoutoglou

Titel van de onderzoeker: Professor of anesthesiology

Sleutelwoorden
Heeft uitgebreide toegang No
Conditie Bladeren
Aantal wapens 2
Arm groep

Label: DEXMEDETOMIDINE AND AKI

Type: Active Comparator

Omschrijving: The patients of the group undergoing EVAR under general anesthesia will receive dexmedetomidine intraoperatively.

Label: CONTROL AND AKI

Type: No Intervention

Omschrijving: The patients of the group undergoing EVAR under general anesthesia will not receive dexmedetomidine intraoperatively.

Acroniem DEVAR
Patiëntgegevens No
Bestudeer ontwerpinformatie

Toewijzing: Randomized

Interventiemodel: Parallel Assignment

Primair doel: Prevention

Maskeren: Triple (Participant, Investigator, Outcomes Assessor)

Bron: ClinicalTrials.gov

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