The Effect of Dexmedetomidine on Kidney Function in EVAR
The Effect of Dexmedetomidine on the Incidence of Acute Kidney Injury in EVAR
| Sponsors |
Lead Sponsor: University of Thessaly |
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| Source | University of Thessaly | ||||||||
| Brief Summary | This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia |
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| Detailed Description | This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin. |
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| Overall Status | Not yet recruiting | ||||||||
| Start Date | March 30, 2021 | ||||||||
| Completion Date | February 1, 2024 | ||||||||
| Primary Completion Date | November 30, 2023 | ||||||||
| Phase | N/A | ||||||||
| Study Type | Interventional | ||||||||
| Primary Outcome |
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| Secondary Outcome |
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| Enrollment | 200 | ||||||||
| Condition | |||||||||
| Intervention |
Intervention Type: Drug Intervention Name: Dexmedetomidine Description: Administration of dexmedetomidine intraoperatively Arm Group Label: DEXMEDETOMIDINE AND AKI |
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| Eligibility |
Criteria:
Inclusion Criteria: - elective EVAR under general anesthesia - adult patients 18- 85 years old - American society of anesthesiologists (ASA) physical status I - IV Exclusion Criteria: - refusal to participate or sign the informed consent form - GFR < 50ml/mim - Bradyarrhythmia <50/min - Hemodynamic instability - Known allergy to Dexmedetomidine - Severe hepatic insufficiency Gender: All Minimum Age: 18 Years Maximum Age: 85 Years Healthy Volunteers: No |
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| Overall Official |
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| Overall Contact |
Last Name: Eleni Arnaoutoglou, MD, PhD Phone: +306974301352 Email: [email protected] |
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| Location |
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| Location Countries |
Greece |
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| Verification Date |
February 2021 |
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| Responsible Party |
Type: Principal Investigator Investigator Affiliation: University of Thessaly Investigator Full Name: Elena Arnaoutoglou Investigator Title: Professor of anesthesiology |
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| Keywords | |||||||||
| Has Expanded Access | No | ||||||||
| Condition Browse | |||||||||
| Number Of Arms | 2 | ||||||||
| Arm Group |
Label: DEXMEDETOMIDINE AND AKI Type: Active Comparator Description: The patients of the group undergoing EVAR under general anesthesia will receive dexmedetomidine intraoperatively. Label: CONTROL AND AKI Type: No Intervention Description: The patients of the group undergoing EVAR under general anesthesia will not receive dexmedetomidine intraoperatively. |
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| Acronym | DEVAR | ||||||||
| Patient Data | No | ||||||||
| Study Design Info |
Allocation: Randomized Intervention Model: Parallel Assignment Primary Purpose: Prevention Masking: Triple (Participant, Investigator, Outcomes Assessor) |
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