The Effect of Dexmedetomidine on Kidney Function in EVAR

The Effect of Dexmedetomidine on the Incidence of Acute Kidney Injury in EVAR

Patrocinadores

Patrocinador principal: University of Thessaly

Fuente University of Thessaly
Resumen breve

This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia

Descripción detallada

This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.

Estado general Not yet recruiting
Fecha de inicio March 30, 2021
Fecha de Terminación February 1, 2024
Fecha de finalización primaria November 30, 2023
Fase N/A
Tipo de estudio Interventional
Resultado primario
Medida Periodo de tiempo
Incidence of Acute Kidney Injury 1st Postoperative Day
Resultado secundario
Medida Periodo de tiempo
Incidence of postoperative ICU admission Operation day to 5th postoperative day
Incidence of arrhythmia Up to 24 hours after surgery
Incidence of Postoperative Delirium Operation day to 4th postoperative day
Inscripción 200
Condición
Intervención

Tipo de intervención: Drug

Nombre de intervención: Dexmedetomidine

Descripción: Administration of dexmedetomidine intraoperatively

Etiqueta de grupo de brazo: DEXMEDETOMIDINE AND AKI

Elegibilidad

Criterios:

Inclusion Criteria: - elective EVAR under general anesthesia - adult patients 18- 85 years old - American society of anesthesiologists (ASA) physical status I - IV Exclusion Criteria: - refusal to participate or sign the informed consent form - GFR < 50ml/mim - Bradyarrhythmia <50/min - Hemodynamic instability - Known allergy to Dexmedetomidine - Severe hepatic insufficiency

Género: All

Edad mínima: 18 Years

Edad máxima: 85 Years

Voluntarios Saludables: No

Oficial general
Contacto general

Apellido: Eleni Arnaoutoglou, MD, PhD

Teléfono: +306974301352

Email: [email protected]

Ubicación
Instalaciones: Contacto: Copia de seguridad de contactos: Investigador: Univeristy of Thessaly Eleni Arnaoutoglou, MD, PhD 2413501370 [email protected] Eleni Arnaoutoglou, MD, PhD Principal Investigator Metaxia Bareka, MD, PhD Sub-Investigator Konstantinos Stamoulis, MD, PhD Principal Investigator
Ubicacion Paises

Greece

Fecha de verificación

February 2021

Fiesta responsable

Tipo: Principal Investigator

Afiliación del investigador: University of Thessaly

Nombre completo del investigador: Elena Arnaoutoglou

Título del investigador: Professor of anesthesiology

Palabras clave
Tiene acceso ampliado No
Condición Examinar
Número de brazos 2
Grupo de brazo

Etiqueta: DEXMEDETOMIDINE AND AKI

Tipo: Active Comparator

Descripción: The patients of the group undergoing EVAR under general anesthesia will receive dexmedetomidine intraoperatively.

Etiqueta: CONTROL AND AKI

Tipo: No Intervention

Descripción: The patients of the group undergoing EVAR under general anesthesia will not receive dexmedetomidine intraoperatively.

Acrónimo DEVAR
Datos del paciente No
Información de diseño del estudio

Asignación: Randomized

Modelo de intervención: Parallel Assignment

Propósito primario: Prevention

Enmascaramiento: Triple (Participant, Investigator, Outcomes Assessor)

Fuente: ClinicalTrials.gov