- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT00042198
Treatment of Depression After Coronary Bypass Surgery
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
Depression is a very common problem for people who have had CABG surgery, and recent studies have shown that it may increase the risk of additional medical problems and death during the first few years after surgery. Cognitive behavior therapy (CBT) has been shown to be efficacious for depression in otherwise healthy individuals, and supportive stress management (SSM) interventions have also been shown to improve depressive symptoms. These therapies have not, however, been tested for depression in individuals who have undergone CABG surgery.
Participants will be screened for depression within 1 year after CABG surgery. Those who have depression will return for additional testing 1 week later. Eligible participants will be randomized to receive CBT, SSM, or usual care (UC), with no restrictions on nonstudy antidepressants, for 12 weeks. Patients will be monitored for worsening depression referred for additional care if needed. Depression, anxiety, and health-related quality of life will be assessed at baseline, 12 weeks after randomization, and 6 months after surgery (2 months after termination of CBT or SSM).
Studietype
Registrering (Faktiske)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
-
-
Missouri
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St. Louis, Missouri, Forente stater, 63108
- Washington University School of Medicine
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-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Coronary Artery Bypass Graft (CABG) surgery (alone or combined with valvular or carotid surgery) within past 12 months
- Meets DSM-IV criteria for major or minor depressive episode
Exclusion Criteria:
- Severe cognitive impairment
- Severe psychiatric comorbidity (e.g., alcoholism or schizophrenia)
- Severely debilitating or life-threatening illness other than coronary disease
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Enkelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
---|---|
Eksperimentell: 1
Cognitive Behavior Therapy.
The treatment modality was individual, face-to-face therapy with an experienced cognitive therapist.
Treatment consisted of up to 12 weekly, hour-long sessions.
|
Up to 12 weekly, individual, hour-long sessions
|
Aktiv komparator: 2
Supportive Stress Management.
The treatment modality was individual, face-to-face therapy with an experienced psychotherapist.
Treatment consisted of up to 12 weekly, hour-long sessions.
|
Up to 12 weekly, individual, hour-long sessions, focusing on application of relaxation and other stress management techniques to depressogenic stressors
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Ingen inngripen: 3
Usual Care, minimally enhanced.
Participants in all three arms were given information about depression.
There were no restrictions in any of the arms on usual care for depression, heart disease, or any other conditions, except that concurrent participation in nonstudy psychotherapy was not allowed.
Participants were allowed to continue or start on nonstudy antidepressants during the study, as prescribed by the participant's personal physician.
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Hamilton Rating Scale for Depression (HAM-D-17)
Tidsramme: 12 weeks post-randomization
|
The HAM-D-17 is an observer-rated measure of the severity of depression.
|
12 weeks post-randomization
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Beck Depression Inventory
Tidsramme: 12 weeks post-randomization
|
The BDI is a self-report measure of the severity of depression.
|
12 weeks post-randomization
|
Beck Anxiety Inventory
Tidsramme: 12 weeks post-randomization
|
The BAI is a self-report measure of the severity of anxiety symptoms.
|
12 weeks post-randomization
|
Beck Hopelessness Scale
Tidsramme: 12 weeks post-randomization
|
The BHS is a self-report measure of hopelessness.
|
12 weeks post-randomization
|
Perceived Stress Scale
Tidsramme: 12 weeks post-randomization
|
The PSS is a self-report measure of perceived stress
|
12 weeks post-randomization
|
SF-36
Tidsramme: 12 weeks post-randomization
|
The Medical Outcomes Study SF-36 is a measure of health-related quality of life.
The Physical and Mental factor scores will be reported.
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12 weeks post-randomization
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Samarbeidspartnere og etterforskere
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Kenneth E Freedland, Ph.D., Washington University School of Medicine
Publikasjoner og nyttige lenker
Hjelpsomme linker
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- R01MH060735 (U.S. NIH-stipend/kontrakt)
- DSIR AT-AS
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