- ICH GCP
- Registro degli studi clinici negli Stati Uniti
- Sperimentazione clinica NCT00042198
Treatment of Depression After Coronary Bypass Surgery
Panoramica dello studio
Stato
Condizioni
Intervento / Trattamento
Descrizione dettagliata
Depression is a very common problem for people who have had CABG surgery, and recent studies have shown that it may increase the risk of additional medical problems and death during the first few years after surgery. Cognitive behavior therapy (CBT) has been shown to be efficacious for depression in otherwise healthy individuals, and supportive stress management (SSM) interventions have also been shown to improve depressive symptoms. These therapies have not, however, been tested for depression in individuals who have undergone CABG surgery.
Participants will be screened for depression within 1 year after CABG surgery. Those who have depression will return for additional testing 1 week later. Eligible participants will be randomized to receive CBT, SSM, or usual care (UC), with no restrictions on nonstudy antidepressants, for 12 weeks. Patients will be monitored for worsening depression referred for additional care if needed. Depression, anxiety, and health-related quality of life will be assessed at baseline, 12 weeks after randomization, and 6 months after surgery (2 months after termination of CBT or SSM).
Tipo di studio
Iscrizione (Effettivo)
Fase
- Non applicabile
Contatti e Sedi
Luoghi di studio
-
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Missouri
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St. Louis, Missouri, Stati Uniti, 63108
- Washington University School of Medicine
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Criteri di partecipazione
Criteri di ammissibilità
Età idonea allo studio
Accetta volontari sani
Sessi ammissibili allo studio
Descrizione
Inclusion Criteria:
- Coronary Artery Bypass Graft (CABG) surgery (alone or combined with valvular or carotid surgery) within past 12 months
- Meets DSM-IV criteria for major or minor depressive episode
Exclusion Criteria:
- Severe cognitive impairment
- Severe psychiatric comorbidity (e.g., alcoholism or schizophrenia)
- Severely debilitating or life-threatening illness other than coronary disease
Piano di studio
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Separare
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
---|---|
Sperimentale: 1
Cognitive Behavior Therapy.
The treatment modality was individual, face-to-face therapy with an experienced cognitive therapist.
Treatment consisted of up to 12 weekly, hour-long sessions.
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Up to 12 weekly, individual, hour-long sessions
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Comparatore attivo: 2
Supportive Stress Management.
The treatment modality was individual, face-to-face therapy with an experienced psychotherapist.
Treatment consisted of up to 12 weekly, hour-long sessions.
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Up to 12 weekly, individual, hour-long sessions, focusing on application of relaxation and other stress management techniques to depressogenic stressors
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Nessun intervento: 3
Usual Care, minimally enhanced.
Participants in all three arms were given information about depression.
There were no restrictions in any of the arms on usual care for depression, heart disease, or any other conditions, except that concurrent participation in nonstudy psychotherapy was not allowed.
Participants were allowed to continue or start on nonstudy antidepressants during the study, as prescribed by the participant's personal physician.
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
Hamilton Rating Scale for Depression (HAM-D-17)
Lasso di tempo: 12 weeks post-randomization
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The HAM-D-17 is an observer-rated measure of the severity of depression.
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12 weeks post-randomization
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Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
---|---|---|
Beck Depression Inventory
Lasso di tempo: 12 weeks post-randomization
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The BDI is a self-report measure of the severity of depression.
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12 weeks post-randomization
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Beck Anxiety Inventory
Lasso di tempo: 12 weeks post-randomization
|
The BAI is a self-report measure of the severity of anxiety symptoms.
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12 weeks post-randomization
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Beck Hopelessness Scale
Lasso di tempo: 12 weeks post-randomization
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The BHS is a self-report measure of hopelessness.
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12 weeks post-randomization
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Perceived Stress Scale
Lasso di tempo: 12 weeks post-randomization
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The PSS is a self-report measure of perceived stress
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12 weeks post-randomization
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SF-36
Lasso di tempo: 12 weeks post-randomization
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The Medical Outcomes Study SF-36 is a measure of health-related quality of life.
The Physical and Mental factor scores will be reported.
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12 weeks post-randomization
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Collaboratori e investigatori
Collaboratori
Investigatori
- Investigatore principale: Kenneth E Freedland, Ph.D., Washington University School of Medicine
Pubblicazioni e link utili
Collegamenti utili
Studiare le date dei record
Studia le date principali
Inizio studio
Completamento primario (Effettivo)
Completamento dello studio (Effettivo)
Date di iscrizione allo studio
Primo inviato
Primo inviato che soddisfa i criteri di controllo qualità
Primo Inserito (Stima)
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Stima)
Ultimo aggiornamento inviato che soddisfa i criteri QC
Ultimo verificato
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- R01MH060735 (Sovvenzione/contratto NIH degli Stati Uniti)
- DSIR AT-AS
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .
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