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Precise Diagnosis, Treatment and Prognostic Evaluation of Complicated Adrenal Tumor Diseases

17. desember 2021 oppdatert av: Wang Weiqing, Shanghai Jiao Tong University School of Medicine

The adrenal gland is an important organ that produces life hormones. There are many types of adrenal tumors, which tend to occur in young adults and affect the whole body. It has the dual threat: hormone secretion and tumor metastasis. At present, there are four major dilemmas in the clinical diagnosis and treatment of adrenal tumors: 1) Pulse secretion of the hormones, which are affected by many factors; and the diagnostic value of single hormone is limited; 2) Traditional imaging cannot accurately reflect the characteristics of hormone secretion. The prognosis cannot be accurately predicted; 3) The molecular characteristics of tumor cells and the microenvironment are unclear, making it difficult to implement early diagnosis and precise treatment; 4) Traditional pathology cannot determine the nature and long-term prognosis of the tumor, which makes the treatment delay, and the disease prognosis is extremely poor. It threatens the lives of patients.

Starting from solving the above-mentioned key problems in the early stage, the research team has systematically established new clinical diagnostic technologies, hormone dynamic tests to accurately assess hormone secretion and segmented blood collection hormone determination technologies to accurately locate adrenal tumors; A series of important research results have been published in Science, Lancet Diabetes & Endocrinology, Cell Research, etc To sum up, the goal of this research is improving the early diagnosis rate of complicated adrenal tumors especially in malignant tumors, developing the optimal treatment plan, avoiding unnecessary surgical treatment, improving the quality of life of patients, reducing mortality. This project will further integrate the adrenal cortex and medulla hormone mass spectrometry detection and the molecular markers of adrenal tumors through phenotypic, functional imaging, and molecular pathological evaluations, and built a sensitive drug screening platform that integrates visual drug response and molecular characteristics, thereby achieving precise diagnosis and treatment of complicated adrenal tumors.

Studieoversikt

Status

Rekruttering

Forhold

Intervensjon / Behandling

Studietype

Observasjonsmessig

Registrering (Forventet)

1000

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Studer Kontakt Backup

  • Navn: Luming Wu, PhD
  • Telefonnummer: 8621-64370045
  • E-post: wulum@126.com

Studiesteder

  • Kina
    • Shanghai
      • Shanghai, Shanghai, Kina, 200025
        • Rekruttering
        • Ruijin Hospital
        • Ta kontakt med:
          • Yiran Jiang

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 75 år (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

Inclusion Criteria:

  • Age ≥ 18 years old and ≤ 75 years
  • Diagnosis of Patients with primary aldosteronism, pheochromocytoma, and cortical cancer
  • Gender: males and females
  • Provide written informed consent
  • Satisfactory compliance

Exclusion Criteria:

  1. Patients with renal insufficiency (Cr>2 times the upper limit of normal).
  2. Patients with a history of liver cirrhosis.
  3. Patients who are currently using corticosteroids.
  4. Patients with cardiac insufficiency (NYHA cardiac function classification grade 3 and above or EF<50%).
  5. Patients with stroke and acute myocardial infarction in the past 6 months.
  6. Patients during pregnancy and lactation

Beskrivelse

Inclusion Criteria:

  • Age ≥ 18 years old and ≤ 75 years
  • Diagnosis of Patients with primary aldosteronism, pheochromocytoma, and cortical cancer
  • Gender: males and females
  • Provide written informed consent
  • Satisfactory compliance

Exclusion Criteria:

  1. Patients with renal insufficiency (Cr>2 times the upper limit of normal).
  2. Patients with a history of liver cirrhosis.
  3. Patients who are currently using corticosteroids.
  4. Patients with cardiac insufficiency (NYHA cardiac function classification grade 3 and above or EF<50%).
  5. Patients with stroke and acute myocardial infarction in the past 6 months.
  6. Patients during pregnancy and lactation

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Kohorter og intervensjoner

Gruppe / Kohort
Intervensjon / Behandling
Primær aldosteronisme
Annen: surgery or drug
pheochromocytoma and adrenocortical carcinoma need surgery and primary aldosteronism need drug according to the genetic results
pheochromocytoma
Annen: surgery or drug
pheochromocytoma and adrenocortical carcinoma need surgery and primary aldosteronism need drug according to the genetic results
adrenocortical carcinoma
Annen: surgery or drug
pheochromocytoma and adrenocortical carcinoma need surgery and primary aldosteronism need drug according to the genetic results

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
tumor biochemical marker treatment response
Tidsramme: 20 years

  • Complete remission (normalization of tumor markers);

    • Partial remission (reduction of tumor markers ≥ 50%); ③No change (decrease of tumor markers <50% or increase ≤25%); ④Disease progression (tumor markers increased> 25%).
20 years
Tumor volume assessment: According to RECIST (version 1.1).
Tidsramme: 20 years

  • Complete response: All target lesions disappear, and the short axis of any pathological lymph nodes must be reduced to <10 mm.

    • Partial Response: The total diameter of the target lesions is reduced by at least 30% compared with the baseline.

      • Progressive Disease: Take the minimum value of the sum of the diameters of all target lesions measured during the study as the reference, and the relative increase in diameter sum by at least 20% ④Stable Disease: Based on the minimum value of the sum of the diameters of all target lesions measured during the study, the reduction of the target lesion did not reach PR, and the degree of increase did not reach PD, between PR and PD.
20 years

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Shanghai Jiao Tong University School of Medicine

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

30. august 2021

Primær fullføring (Forventet)

30. august 2040

Studiet fullført (Forventet)

30. august 2041

Datoer for studieregistrering

Først innsendt

24. august 2020

Først innsendt som oppfylte QC-kriteriene

24. august 2020

Først lagt ut (Faktiske)

27. august 2020

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

27. desember 2021

Siste oppdatering sendt inn som oppfylte QC-kriteriene

17. desember 2021

Sist bekreftet

1. desember 2021

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • CCEMD-2020-0825

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

UBESLUTTE

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Kliniske studier på Complicated Adrenal Tumor Diseases

Kliniske studier på surgery or drug

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