Imaging Airway Liquid Absorption in Cystic Fibrosis

Inclusion Criteria:

• Adult healthy control arm:

  • subjects 18 years old or older without a diagnosis of lung disease.

• Pediatric CF arm:

  • subjects 6-14 years with a diagnosis of cystic fibrosis as determined by sweat test or genotype
  • subjects who are clinically stable as determined by the pediatrician co-investigator
  • subjects must have a previously demonstrated ability to perform reproducible pulmonary function testing based on previous clinical visits.
• Females in all groups who are of child-bearing potential will need to have a negative urine pregnancy test.

Exclusion Criteria:

• Adult healthy control arm:

  • FEV1%p < 80% of predicted
  • nursing mother
  • positive urine pregnancy test or unwilling to test
  • cigarette smoker (regular smoking within 6 months of study).

• Pediatric CF arm:

  • FEV1%p < 40% of predicted
  • nursing mother
  • positive urine pregnancy test for females of childbearing potential
  • unable or unwilling to comply with test procedure
  • cigarette smoker (regular smoking within 6 months of study).
  • Subjects unable to lie recumbent without moving for the 80 minute imaging period will be excluded.