Pharmacokinetic Evaluation of EXPAREL in Adults Undergoing Tonsillectomy

Inclusion Criteria:

• Male or female, ≥18 years of age at the Screening Visit.
• Subjects undergoing tonsillectomy with or without removal of the adenoids.
• Able and willing to comply with all study visits and procedures.
• Willing and capable of providing written informed consent.

Exclusion Criteria:

• History of hypersensitivity or idiosyncratic reaction to amide-type local anesthetics.
• Received any investigational drug within 30 days prior to EXPAREL administration, and/or has planned administration of another investigational product or procedure while participating in this study.
• Currently pregnant, nursing, or planning to become pregnant during the study or within 1 month after EXPAREL administration. Female subjects must be surgically sterile, at least 2 years postmenopausal, or using an acceptable method of birth control. If of childbearing potential, must have a documented negative pregnancy test within 24 hours before EXPAREL administration.
• Subjects with significant medical conditions or laboratory results that, in the opinion of the Investigator, indicate an increased vulnerability to EXPAREL and/or procedures, or cause inability to comply with the study requirements.