Phospholipid and Sphingolipid Composition of High-density Lipoproteins (HDL) in Obese Non-diabetic Patients With Metabolic Syndrome (SPHINGO)

Inclusion Criteria:

• aged > 18 years
• fasting glycaemia < 1.10 g/l
• waist circumference > 102 cm for men and 88 cm for women (criteria NCEP/ATP III)
• 2 criteria among the following 3 (NCEP/ATP III criteria for metabolic syndrome):
• triglyceridaemia ≥ 1.50 g/l
• HDL cholesterol < 0.40 g/l for men and 0.50 g/l for women
• arterial blood pressure ≥ 130/85 mmHg or treatment for arterial hypertension
• patients who have provided written consent INCLUSION CRITERIA FOR HEALTHY SUBJECTS
• age > 18 years
• fasting glycaemia < 1.10 g/l
• waist circumference < 102 cm for men and 88 cm for women
• triglyceridaemia < 1.50 g/l
• HDL cholesterol ≥ 0.40 g/l for men and 0.50 g/l for women
• Healthy subjects who have provided written consent

Exclusion Criteria:

• Persons without national health insurance cover
• Diabetes
• Diseases that interfere with lipoprotein metabolism (dysthyroidism not controlled with the treatment, kidney or liver disease)
• Treatments that interfere with lipoprotein metabolism (lipid-lowering agents, oestrogens, corticoids, retinoids, antiretroviral agents)
• Pregnancy/breast feeding