- ICH GCP
- Registro de ensaios clínicos dos EUA
- Ensaio Clínico NCT03923205
Assessing the Effects of a Buckwheat Beverage on Postprandial Glucose Metabolism on Healthy and T2D Individuals (BUCKFOOD)
Buckwheat is a unique crop because is naturally rich in compounds that have shown beneficial effects on glucose metabolism.
A constant high glucose level in blood after meal consumption is an independent risk factor for cardiovascular complications and death. In order to prevent Type 2 Diabetes Mellitus (T2D) and/or its complications it is important to have a strict control of the blood glucose levels after a meal. There are known therapies for the control of the high glucose blood levels such as agents that act on intestinal digestion of carbohydrates and therapeutic agents that mimic the insulin response after a meal. The combination of these type of agents was commonly prescribed in the treatment of T2D.
The aim of the study is to assess the effect of a buckwheat beverage on postprandial glucose metabolism in healthy individuals and those with T2D controlled by medication and diet.
Visão geral do estudo
Status
Condições
Intervenção / Tratamento
Descrição detalhada
The ability of the buckwheat beverage to modulate postprandial sugar metabolism will be tested in a dietary study in healthy volunteers and people with T2D. Three groups will be recruited; healthy volunteers, individuals with T2D controlled by medication and individuals with T2D controlled by diet and lifestyle only.
For the human volunteers who have T2D controlled by medication, there will be targeted those who have been prescribed metformin only.
The volunteers will visit the Human Nutrition Unit (HNU) three times (a screening visit and two study visits) during the course of the study.
A minimum of two weeks between the study visits will be allowed.
Screening visit:
Once the consent form has been signed, the volunteers taking part in the study will answer a specific health questionnaire and have their blood sugar level measured. The HbA1c (glycated haemoglobin) will be measured using the AS-100 (finger spot blood). We will follow the NHS guideline to establish the values for HbA1c. A normal HbA1c target is below 48 mmol/mol (or 6.5%).
In addition, for the volunteers with T2D, a consultant from the study research team will access the medical records to ensure their eligibility for the study. Permission will be obtained from the volunteers for this via the study consent form.
Dietary study test meal and control meal:
The test meal The buckwheat beverage is prepared from sprouted buckwheat flour without adding any extra sugar, spices or aromas. The test meal contains 100 g of the buckwheat beverage and 75 g glucose dissolved in 300 mL water followed by 100 mL water.
The control meal The control meal will be a standard OGT test containing 75 g glucose dissolved in 300 mL of water followed by 100 mL water.
Both meals will be advised to be consumed within 5 minutes. The T2D volunteers which are on metformin will be advised to take their medication as usual. We will record the dose and time when the metformin will be taken by the volunteers.
Dietary study visits:
Following recruitment, screening and consent, the three groups of volunteers will start the study by random allocation to one of the test meals. On the study day, the volunteers will be advised to come to the HNU in the morning after an overnight fasting (10 h). A cannula will be inserted into the volunteers' arm and baseline blood will be collected. The cannulation and blood sampling will be performed by trained phlebotomists. Additionally a baseline urine sample will be collected. The urine sample either will be brought in by the volunteers in the morning or produced in HNU before the test meals. The volunteers will be served the control and test meal (depending on allocation) and advised that it is to be consumed within five minutes. Volunteers which are on metformin will be asked to take their medication as usual.
For each study visit, blood will be collected at 0, 15, 30, 45, 60, 75, 90, 105, 120, 150, 180 and 300 min. The blood will be collected in 4 mL lithium heparin tubes and 4 mL glucose (fluoride oxalate) tubes at each time point. A volume of 96 mL of blood will be collected at each study visit. Additionally a volume of 5 μL blood will be collected for each time point in order to instantly measure the glucose levels. At least two samples will be collected at t=0 in order to obtain a good baseline value.
The movements of the volunteers will be restricted to minimum for the entire blood collection period. They will be asked to stay resting and comfortable position and relaxed for the entire (300 min) sampling period and to not leave the HNU.
After five hours, once all the blood samples have been collected the cannula will be extracted from the volunteer's arm and lunch will be provided.
Tipo de estudo
Inscrição (Antecipado)
Estágio
- Não aplicável
Contactos e Locais
Locais de estudo
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Aberdeen, Reino Unido, AB 25 2ZD
- Recrutamento
- Rowett Institute, University of Aberdeen
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Contato:
- Madalina Neacsu, PhD
- Número de telefone: 00441224438760
- E-mail: m.neacsu@abdn.ac.uk
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
Aceita Voluntários Saudáveis
Gêneros Elegíveis para o Estudo
Descrição
Inclusion Criteria:
Healthy and T2D (controlled by diet and lifestyle or metformin) volunteers; Age 18+; males and females.
Exclusion Criteria:
For the healthy group:
- taking prescribed medication
- HbA1c above 48mmol/mol (or 6.5%)
- pregnant or breastfeeding
- blood donation in the last three months
- unable to give written informed consent
- eating disorders such as anorexia, bulimia, binge eating or night eating syndrome.
- significant health issue
- taking vitamin or mineral supplements (unless they agree to discontinue supplementation 2 weeks or more before the start of the study)
- Food allergies/intolerances
For the T2D groups:
- T2D controlled by medication other than metformin
- pregnant or breastfeeding
- blood donation in the last three months
- unable to give written informed consent
- eating disorders such as anorexia, bulimia, binge eating or night eating syndrome.
- any other significant health issue other than T2D
- taking vitamin or mineral supplements (unless they agree to discontinue supplementation 2 weeks before the start of the study)
- food allergies/intolerances
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Prevenção
- Alocação: Randomizado
- Modelo Intervencional: Atribuição Paralela
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
---|---|
Comparador Ativo: Control meal
The control meal will be a standard OGT test containing 75 g glucose dissolved in 300 mL of water followed by 100 mL water.
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The effect of a buckwheat beverage on postprandial glucose metabolism in healthy individuals and those with T2D controlled by medication and diet will be studied.
|
Comparador Ativo: The test meal
The test meal contains 100 g of the buckwheat beverage and 75 g glucose dissolved in 300 mL water followed by 100 mL water.
|
The effect of a buckwheat beverage on postprandial glucose metabolism in healthy individuals and those with T2D controlled by medication and diet will be studied.
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
---|---|---|
post prandial blood glucose (recording cmax)
Prazo: five hours
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Postprandial blood glucose levels after acute consumption of a buckwheat beverage, recording the maximum blood glucose concentration (c max) over the baseline after the consumption of a buckwheat beverage.
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five hours
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AUC for postprandial glucose
Prazo: five hours
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Area under the curve described by the postprandial glucose level during five hours time
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five hours
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
---|---|---|
post prandial blood insulin in blood ( including AUC)
Prazo: five hours
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Post prandial blood insulin levels after acute consumption of a buckwheat beverage.
AUC (area under curve) for insulin for five hour interval.
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five hours
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Buckwheat beverage key bioactives bioavailability and metabolism.
Prazo: five hours
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Plasma concentration of key bioactives (inositols and fagomines)
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five hours
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Urine ratio of myo and D-chiro inositol
Prazo: 0, 3 and 5 hours
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Urine ratio of myo and D-chiro inositol after the consumption of a buckwheat beverage.
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0, 3 and 5 hours
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Urine glucose concentration
Prazo: 0, 3 and 5 hours
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Glucose concentration in urine after the consumption of a buckwheat beverage.
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0, 3 and 5 hours
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Colaboradores e Investigadores
Patrocinador
Colaboradores
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Real)
Conclusão Primária (Antecipado)
Conclusão do estudo (Antecipado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- 2-088-18
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