University Hospital started a clinical trial of DNA Damage in Critically Ill COVID-19 Patients
University Hospital Hradec Kralove is commencing recruitment for the clinical trial of the DNA Damage in Critically Ill COVID-19 Patients.
The conditions are Covid19, Organ Failure, Multiple, DNA Damage.
A new clinical trial is recruiting patients in the following locations: Czechia.
The trial officially began on the November 23, 2020 and is planned to complete on July 30, 2021.
Critically ill patients with COVID-19 are exposed to high oxidative stress which is potential harm to the DNA. Peripheral lymphocytes' DNA will be investigated using the comet assay on changes in oxidative damage to the purine and pyrimidine bases and single-stranded DNA breaks.
Data from hospital documentation will be recorded for all patients: demographic data, clinical data (Horowitz index, the necessity of pronation position, opening maneuvers, connection to ECMO, state of the circulation and other organ functions), laboratory data: parameters of inflammatory activity and COVID-19 specific markers (blood count with differential leukocyte count, CRP, IL-6, ferritin, procalcitonin, D-dimers).
The population that can be enrolled into this study includes critically ill patients admitted to ICU with signs and symptoms of organ failure, mainly respiratory failure, need for means of respiratory and/or circulatory support and have a positive test of COVID-19: RT-PCR test or bed-side antigen test.
University of Hradec Králové (in Czech Univerzita Hradec Králové, in Latin Universitas Reginaegradecensis) was founded on June 21, 2000 by renaming the University College of Education (Vysoká škola pedagogická), which itself traces its roots back to 1959. It is attended by around 8,500 students.
It belongs to one of the most important education and research institutions in the Eastern Bohemia.
The current rector of the university is prof. Ing. Kamil Kuča, Ph.D.
The link to the complete study profile: https://ichgcp.net/clinical-trials-registry/NCT04772703
