DNA Analysis of Blood and Tissue From Patients With Lung Cancer
Molecular and Genetic Analysis of Lung Cancer
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future.
PURPOSE: This clinical trial is analyzing the DNA in blood and tissue samples from patients with lung cancer.
Studieöversikt
Status
Betingelser
Detaljerad beskrivning
OBJECTIVES:
- Assess the role of genetic polymorphisms in lung-cancer risk in patients with lung cancer.
- Assess the role of germline polymorphisms in DNA repair genes, p53 pathway genes, and a matrix metalloproteinase gene (tumor invasion factor) in lung-cancer risk, after adjusting for potential confounders.
- Assess the roles of gender and age in the genetic susceptibility of lung cancer.
- Assess the role of genetic polymorphisms in modifying the diet-lung cancer risk association (gene-diet and exploratory gene-gender-diet and gene-gene-diet interactions).
- Assess the role of polymorphisms on the risk of developing specific histologic subtypes of lung cancer in case-only analyses.
- Determine whether continued exposures to mainstream and/or second-hand tobacco smoking is associated with poorer clinical prognosis in patients treated for lung cancer.
OUTLINE: This began as a case-control study, but is currently case only.
Blood samples are collected from patients and controls. Samples are analyzed by polymerase chain reaction for gene polymorphisms. Genes to be studied include GSTP1, GSTM1, GSTT1, ERCC2, XRCC1, EPHX, NAT-2, p53 gene, CYP1A1, NQO1, MnSOD, and GPX1. Tissue samples collected from patients undergoing surgery and blood samples are archived for future studies.
Patients and controls complete questionnaires about diet, medical history, and occupational/environmental history.
PROJECTED ACCRUAL: A total of 3,400 patients and 3,400 controls will be accrued for this study.
Studietyp
Inskrivning (Förväntat)
Kontakter och platser
Studieorter
-
-
Massachusetts
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Boston, Massachusetts, Förenta staterna, 02114
- Rekrytering
- Massachusetts General Hospital
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Kontakt:
- Clinical Trials Office - Massachusetts General Hospital
- Telefonnummer: 877-726-5130
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Boston, Massachusetts, Förenta staterna, 02115
- Rekrytering
- Harvard School of Public Health
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Kontakt:
- David C. Christiani, MD
- Telefonnummer: 617-726-9274
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-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
DISEASE CHARACTERISTICS:
Patient:
Newly diagnosed primary lung cancer
- Patient at Massachusetts General Hospital (MGH) or Boston Medical Center Cancer Center
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
EXCLUSIONS:
Vulnerable populations are excluded. Patients with metastasis from another site to lung or mesothelioma are excluded.
Studieplan
Hur är studien utformad?
Designdetaljer
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Metabolic polymorphisms
Tidsram: 10 years
|
to compare differences among lung cancer patients
|
10 years
|
Samarbetspartners och utredare
Sponsor
Samarbetspartners
Utredare
- Huvudutredare: David C. Christiani, MD, Massachusetts General Hospital
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Förväntat)
Avslutad studie (Förväntat)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- CDR0000450128
- MGH-1999-P-004935/26 (Annan identifierare: Partners Institutional Review Board)
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
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