A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)

Experimentell: MK-0736

Participants will be orally administered 7 mg of MK-0736 once daily for 12 weeks

Läkemedel: Comparator: placebo (unspecified)

Matching Placebo once daily, orally at approximately the same time each morning for 12 weeks.

Placebo-jämförare: Placebo

Participants will be orally administered placebo once daily for 12 weeks.

Läkemedel: MK-0736

MK-0736; 7mg once daily, orally at approximately the same time each morning for 12 weeks.

Change From Baseline in Cluster of Differentiation 68 (CD68)

CD68 is a heavily glycosylated transmembrane protein resident to macrophage lysosomes, and is the standard immunohistochemical (IHC) marker for macrophages in human tissues. CD68 protein content as a measure of macrophage number is the most often reported marker in clinical studies of plaque instability. Blood samples were taken to determine the level of CD69 present at baseline (predose Day 1) and again after 12 weeks of study drug administration in participants with peripheral arterial disease of the lower extremity who are scheduled for excision of an atherosclerotic plaque.

Change From Baseline in Messenger Ribonucleic Acid (mRNA)

mRNA is a biomarker associated with the inflammatory response. Blood samples were taken to determine the level of mRNA present at baseline (predose Day 1) and again after 12 weeks of study drug administration in participants with peripheral arterial disease of the lower extremity who are scheduled for excision of an atherosclerotic plaque.

Number of Participants Who Were Discontinued From the Study Due to an Adverse Event (AE)

An AE is defined as any unfavorable and unintended change in the structure, function, or chemistry of the body temporally associated with the use of the study vaccine, whether or not considered related to the use of the study drug. Any worsening of a preexisting condition which is temporally associated with the use of the study drug is also an AE. The percentage of participants who were discontinued from the study due to an AE was summarized.