- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT02515331
Safety and Efficacy Study of LHW090 in Resistant Hypertension Patients
9 december 2020 uppdaterad av: Novartis Pharmaceuticals
A Randomized, Sponsor Open, Site and Subject Double Blind, Parallel Group, Placebo-controlled Study to Evaluate the Safety and Efficacy of LHW090 After 4 Weeks Treatment in Patients With Resistant Hypertension
The purpose of the present study was to determine whether LHW090 displays the clinical safety and efficacy profile to support further development in patients with resistant hypertension.
Studieöversikt
Status
Avslutad
Betingelser
Intervention / Behandling
Studietyp
Interventionell
Inskrivning (Faktisk)
64
Fas
- Fas 2
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
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Gentofte, Danmark, DK 2820
- Novartis Investigative Site
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Paris, Frankrike, 75015
- Novartis Investigative Site
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Alabama
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Birmingham, Alabama, Förenta staterna, 35294
- Novartis Investigative Site
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California
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North Hollywood, California, Förenta staterna, 91606
- Novartis Investigative Site
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Florida
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Atlantis, Florida, Förenta staterna, 33462
- Novartis Investigative Site
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Daytona Beach, Florida, Förenta staterna, 32117
- Novartis Investigative Site
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Jacksonville, Florida, Förenta staterna, 32216
- Novartis Investigative Site
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Hawaii
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Honolulu, Hawaii, Förenta staterna, 96814
- Novartis Investigative Site
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Tennessee
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Knoxville, Tennessee, Förenta staterna, 37920
- Novartis Investigative Site
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Meibergdreef 9, Nederländerna, 1105 AZ
- Novartis Investigative Site
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Basel, Schweiz, 4031
- Novartis Investigative Site
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Lausanne, Schweiz, 1011
- Novartis Investigative Site
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Berlin, Tyskland, 10098
- Novartis Investigative Site
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Duesseldorf, Tyskland, 40225
- Novartis Investigative Site
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Hannover, Tyskland, 30625
- Novartis Investigative Site
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Homburg, Tyskland, 66421
- Novartis Investigative Site
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Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
40 år till 85 år (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
- Male and female patients, age 40 to 85 years inclusive.
- • Patients with uncontrolled hypertension (here defined as having a mean daytime systolic BP ≥ 135 mmHg by ABPM at screening) despite treatment with a stable (at least 1 month) regimen that includes an optimal dose of an ARB plus a diuretic plus at least one additional class of anti-hypertensive medication.
For the purposes of this trial, optimal doses of anti-hypertensive medications are defined as:
- the highest dose listed in the clinical practice guideline from the American Society for Hypertension and the International Society for Hypertension or
- the highest allowable prescribed dose per the manufacturer's label or
- the highest dose tolerated by an individual patient or
- the highest dose appropriate for an individual patient in the judgment of the Investigator
- Subjects must weigh at least 45 kg to participate in the study and must have a body mass index (BMI) within the range of 18-38 kg/m^2.
Exclusion Criteria:
- Patients with an estimated GFR <60 ml/min/1.73m^2.
- Use of angiotensin converting enzyme inhibitors (ACE-inhibitors). Note: Patients who discontinue their ACE-inhibitor and substitute with an angiotensin receptor blocker may be eligible to be re-screened provided their anti-hypertensive regimen has been stable for at least 1 month. Any substitutions or changes to a patient's anti-hypertensive regimen should be done under the guidance of the patient's treating physician.
- Severe hypertension as defined by systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg at screening.
- A history of secondary hypertension of any etiology including but not limited to unilateral or bilateral renal artery stenosis, polycystic kidney disease, coarctation of the aorta, primary hyperaldosteronism, Cushing's disease, pheochromocytoma, and drug-induced hypertension.
- Known current significant left ventricular outflow obstruction, such as obstructive hypertrophic cardiomyopathy or significant severe valvular disease on prior or current echocardiogram).
- A history of known moderate or malignant retinopathy defined as moderate (retinal signs of hemorrhage), microaneurysms, cotton-wool spots, hard exudates, or a combination thereof) or malignant (signs of moderate retinopathy plus swelling of the optic disk). Patients with a stable ophthalmologic history in the past 6 months are eligible.
- To facilitate ABPM assessment, an upper arm circumference greater than 42 cm.
- History within the previous 6 months of myocardial infarction, coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI), hypertensive encephalopathy, stroke, or transient ischemic attack (TIA).
Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test.
• Women of child-bearing potential
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Trippel
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
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Experimentell: LHW090 100 mg
LHW090 100 mg once daily for 28 days
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Capsule - oral dose
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Experimentell: LHW090 200 mg
LHW090 200 mg once daily for 28 days
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Capsule - oral dose
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Placebo-jämförare: Placebo
Matching placebo to LHW090 oral dose for 28 days
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Capsule - oral dose
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Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
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Number of Participants With Reported Adverse Events (AEs), Serious Adverse Events (SAEs) and Deaths
Tidsram: 6 months
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Number of participants with AEs, SAEs and deaths were assessed.
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6 months
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Change From Baseline in Mean Daytime Blood Pressure
Tidsram: Baseline, day 27
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Change in the 12 hour average of systolic blood pressure (SBP) measured by ambulatory blood pressure was defined as the 12 hour daytime average SBP on Day 28 minus the 12 hour daytime average SBP on Day -1.
monitoring (ABPM).
A negative change from baseline indicates improvement.
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Baseline, day 27
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Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
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Pharmacokinetics of LHW090/LHV527 in Plasma: Observe Maximum Plasma Concentration Following LHW090 at Steady State in Patients (Cmax)
Tidsram: Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Blood samples were collected to assess Cmax.
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Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Pharmacokinetics of LHW090/LHV527 in Plasma: Time to Reach the Maximum Concentration After Administration of LHW090 (Tmax)
Tidsram: Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Blood samples were collected to assess Tmax.
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Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Pharmacokinetics of LHW090/LHV527 in Plasma: Area Under the Plasma Concentration-time Curve From Time Zero to the Time of Last Quantifiable Concentration (AUClast)
Tidsram: Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Blood samples were collected to assess AUClast.
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Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Pharmacokinetics of LHW090/LHV527 in Plasma: Last Measurable Plasma Concentration (Clast)
Tidsram: Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Blood samples were collected to assess Clast.
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Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Pharmacokinetics of LHW090/LHV527 in Plasma:Tlast
Tidsram: Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Blood samples were collected to assess Tlast.
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Within 60 min prior to dosing, post dose: +/- 5 min up to 3 hrs, +/- 10 min from ≥3 hrs up to 12 hrs on Day 1 and Day 28
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Användbara länkar
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
4 november 2015
Primärt slutförande (Faktisk)
17 augusti 2017
Avslutad studie (Faktisk)
17 augusti 2017
Studieregistreringsdatum
Först inskickad
31 juli 2015
Först inskickad som uppfyllde QC-kriterierna
31 juli 2015
Första postat (Uppskatta)
4 augusti 2015
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
5 januari 2021
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
9 december 2020
Senast verifierad
1 juni 2018
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- CLHW090X2202
- 2015-001890-42 (EudraCT-nummer)
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .
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