- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT03805321
The Validity of Peripheral Perfusion Index to Predict Fluid Responsiveness
The Validity of Peripheral Perfusion Index to Predict Fluid Responsiveness Using Mini-fluid Challenge Test
Studieöversikt
Status
Betingelser
Detaljerad beskrivning
The concept of fluid responsiveness has been suggested to guide fluid administration in critically ill patients to avoid either over or under-transfusion.
Several methods have been suggested to detect fluid responsiveness. Mini fluid challenge with concomitant monitoring of stroke volume is one of the most robust methods for pre-load challenge.
The main foreshortening of mini fluid challenge method is the need for a real-time cardiac output monitor, to track the instantaneous change of stroke vole with changing body position. Finding a surrogate to cardiac output to trace the effect of mini fluid challenge would make the test more applicable without the need for advanced hemodynamic monitors.
There is a growing interest in the use of perfusion indices in assessment of fluid responsiveness. Perfusion indices are measures for adequacy of oxygen delivery in peripheral tissues; thus, they were hypothesized to be possible surrogates of cardiac output. Peripheral perfusion index represents "the ratio between the pulsatile and non-pulsatile component of the light reaching the pulse oximeter" . Peripheral perfusion index has been considered as a numerical non-invasive measure for peripheral perfusion. PPI has the advantage over other perfusion indices that it a non-invasive, user-friendly monitor.
The aim of this work is to investigate the ability of peripheral perfusion index to predict the hemodynamic response to mini-fluid challenge in patients with septic shock.
Mini-fluid challenge test will be performed by infusion of 200 mL Lactated Ringer's solution over 1 minute. Velocity time integral will be monitored using Transthoracic echocardiography at the left ventricular outflow tract at the apical five-chamber view. Cardiac output will be calculated, and the patient will be considered fluid-responder if cardiac output increased by 10% after fluid challenge.
Studietyp
Inskrivning (Faktisk)
Kontakter och platser
Studieorter
-
-
-
Cairo, Egypten, 11432
- Ahmed Mohamed Hasanin
-
-
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- Septic shock patients
Exclusion Criteria:
- Evident blood loss
- Peripheral vascular disorders
- Upper limb injury or burns
Studieplan
Hur är studien utformad?
Designdetaljer
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Peripheral perfusion index
Tidsram: 2 hours
|
It is a number describing the ratio between pulsatile and non-pulsatile blood flow measured by pulse oximeter.
It is measured in percent.
with the best value of 20% and the worst value of 0.1%
|
2 hours
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
---|---|---|
Velocity time integral
Tidsram: 2 hours
|
it is a parameter measured from Doppler across the left ventricular outflow tract.
It is calculated by dividing the blood velocity by time and measured in cm
|
2 hours
|
Mean arterial blood pressure
Tidsram: 2 hours
|
Mean arterial blood pressure measured in mmHg
|
2 hours
|
Central venous pressure
Tidsram: 2 hours
|
Central venous pressure measured from a central venous catheter.
It is measured in cmH2o
|
2 hours
|
Systolic arterial blood pressure
Tidsram: 2 hours
|
Systolic arterial blood pressure measured in mmHg
|
2 hours
|
Diastolic arterial blood pressure
Tidsram: 2 hours
|
Diastolic arterial blood pressure measured in mmHg
|
2 hours
|
Cardiac output
Tidsram: 2 hours
|
The amount of blood pumped by the heart in one minute.
it is measured as liters per minute
|
2 hours
|
Samarbetspartners och utredare
Sponsor
Utredare
- Studierektor: Ahmed Shash, Professor, Head of department of anesthesia, Cairo University, Egypt
Publikationer och användbara länkar
Studieavstämningsdatum
Studera stora datum
Studiestart (Faktisk)
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Faktisk)
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- N-138-2018
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Studerar en amerikansk FDA-reglerad produktprodukt
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .
Kliniska prövningar på Septisk chock
-
Charles University, Czech RepublicOkändSeptisk chock | Åderkollapsbarhet | Intravaskulär Doppler | Volymrespons i Septic ShockTjeckien
-
Mongi Slim HospitalOkändTrans Cranial Doppler Ultrasonography in Heamodynamic Optimization in Septic ShockTunisien
-
Biomedizinische Forschungs gmbHMedical University of ViennaAvslutadSepsis | Toxic-Shock Syndrome
-
National Institute of Allergy and Infectious Diseases...Avslutad
-
Luzerner KantonsspitalRekrytering
-
Cairo UniversityAvslutad
-
Assistance Publique Hopitaux De MarseilleAvslutad
-
Cairo UniversityRekrytering
-
Nepal Health Research CouncilFogarty International Center of the National Institute of HealthRekrytering