Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality
The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality
研究概览
详细说明
In Guinea-Bissau, a combined OPV and VAS campaign took place in November 2002. Given the uncertainty about the best dose of VAS, we examined whether the half dose compared with the full dose currently recommended by WHO gave an equally good protection against childhood morbidity and mortality. Mortality after supplementation was lower, though not significantly so, for children who had received the half dose. However, there was a highly significant inversion of the effect for boys and girls; while the low dose was clearly better for girls, the full dose might have been slightly better for boys. The girls' responses to the high versus the low dose of vitamin A might have depended on the last vaccine received before the OPV and VAS campaign.
We believe that these findings call for confirmation. In connection with the OPV and VAS campaign in November 2004 in Guinea-Bissau, we intend to examined whether half the dose of the dose currently recommended by WHO as compared to the full dose has a more beneficial effect on mortality and morbidity in girls, and furthermore address the potential effect modification by the last vaccine received before the supplementation.
研究类型
注册
阶段
- 第四阶段
联系人和位置
学习地点
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Bissau、几内亚比绍
- Bandim Health Project, Apartado 861
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:Between 6 mo and 5 years of age and thus eligible for vitamin A and OPV campaign -
Exclusion Criteria:Overt signs of vitamin A deficiency
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学习计划
研究是如何设计的?
设计细节
- 主要用途:预防
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
研究衡量的是什么?
主要结果指标
结果测量 |
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死亡
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发病率
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All outcomes are investigated for interactions between vitamin A, sex, and last vaccine received
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次要结果测量
结果测量 |
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生长
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Rota infection
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Measles infection
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合作者和调查者
调查人员
- 首席研究员:Peter Aaby, DMSc、Bandim Health Project
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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维生素A的临床试验
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Johns Hopkins UniversityNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)完全的
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Aalborg UniversityAalborg University Hospital; CCBR Aalborg A/S, Aalborg, Denmark完全的