Bioequivalence Study of ARQ 197 Amorphous and Crystalline Polymorphs A and B in Normal Healthy Volunteers

Inclusion Criteria:

• Subject must provide written informed consent prior to any study related procedures
• Subjects must be between the ages of 18 and 65 years
• Male participants must have been surgically sterilized
• Female participants must have been surgically sterilized or be post menopausal and must have a negative serum pregnancy test
• All participants will be phenotypically extensive metabolizers based on their CYP C19 genotype.

Exclusion Criteria:

• Males who are not surgically sterilized
• Females of child-bearing potential who are not surgically sterilized
• Any clinically significant acute or unstable physical or psychological disease based on medical history or screening physical examination
• Any clinically significant abnormality in the screening laboratory tests or ECG
• Received any investigational drugs within four weeks
• Human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV) infection