Long-term Follow-up of Cognitive and Functional Evolutions of Persons With Isolated Cognitive Complaints or Mild Cognitive Deficits (Memento-Plus)
Memento-Plus : Long-term Follow-up of Cognitive and Functional Evolutions of Persons With Isolated Cognitive Complaints or Mild Cognitive Deficits
Dementia is a clinical syndrome that is the result of distinct underlying pathologies including Alzheimer's disease (AD). Despite more than two decades of research on prevention and treatment of dementia and aging-related cognitive decline, highly effective preventive and therapeutic strategies remain elusive.
Many features of dementia render it especially challenging. Indeed development of disease occurs insidiously over the course of years or decade. In addition, the causes of dementia and determinants of its severity are likely multi-factorial.
To overcome these challenges and better understand the causes and course of AD and related disorders, long term follow-up studies of persons at high risk of dementia are required including multidimensional and harmonized assessment of risk factors, phenotypes (cognition, neuropsychiatric symptoms, physical health, self rated health) and endophenotypes (blood markers, genetic markers, neuroimaging markers).
This project proposes an extension of the follow-up of Memento participants over 5 to 10 years with of focus on cognitive outcomes and comorbidities.
研究概览
地位
条件
研究类型
注册 (实际的)
联系人和位置
学习地点
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Amiens、法国
- CHU d'Amiens
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Bobigny、法国
- AP-HP - CHU Avicenne
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Bordeaux、法国
- CHU de Bordeaux - Pellegrin
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Clermont-ferrand、法国
- CHU de Clermont-Ferrand
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Colmar、法国、68000
- Hopitaux Civils de Colmar
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Dijon、法国
- CHU de Dijon
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Grenoble、法国
- CHU de Grenoble
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Lille、法国
- CHU de Lille
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Marseille、法国
- AP-HM
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Montpellier、法国
- CHU de Montpellier
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Nancy、法国
- CHU de nancy
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Nantes、法国
- CHU de Nantes
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Nice、法国
- CHRU de Nice - Institut Claude Pompidou
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Nice、法国
- CHU de Nice - Hôpital de Cimiez
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Paris、法国
- AP-HP - Hôpital BROCA
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Paris、法国
- AP-HP La Pitié-Salpétrière
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Paris、法国
- APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal
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Pessac、法国
- CHU de Bordeaux
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Poitiers、法国
- CHU de POITIERS
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Rouen、法国
- CHU de Rouen
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Saint-etienne、法国
- CHU DE SAINT-ETIENNE
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Strasbourg、法国
- CHU de Strasbourg
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Toulouse、法国
- CHU de Toulouse
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Toulouse、法国
- CHU de Toulouse - Hôpital Purpan
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Tours、法国
- CHU de Tours
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Villeurbanne、法国
- Hospice Civil de Lyon
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Participants aged over 18 year-old
- Being included in Memento cohort
- Affiliated person or beneficiary of a social security scheme.
- Participants capable of expressing non objection
- Non objection expressed by the tutor for participants under tutorship
- Non objection expressed by the participant assisted by their guardian for participants under guardianship
- Non objection expressed by the trusted person (in accordance with art. L1111-6 of Code de la Santé Publique) for participants without the capacity to express non-objection and who are not under legal protection measure
Exclusion Criteria:
- Expressing opposition to participate in Memento-Plus
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Individuals at high risk of developing Alzheimer's dementia
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
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Progression to clinical dementia stage according to standardized classifications (DSM-IV for dementia and NINCDS-ADRDA for Alzheimer's disease)
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Mortality
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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Loss of autonomy based on functional activity assessment
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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Rate of cognitive decline based on change in cognitive performances
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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Incidence of neurovascular and cardiovascular events (Stroke and Coronary events)
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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Quality of life: EQ-5D (EUROQOL)
大体时间：Each 12 months from baseline for 5 years
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EQ-5D (EUROQOL) questionnaire Subscales: VAS patient's self-rated health (0=worst, 100=best), mobility, self-care, usual activities, pain/discomfort and anxiety/depression (rated as no problems, slight problems, moderate problems, severe problems and extreme problems)
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Each 12 months from baseline for 5 years
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Incidence of prodromal AD (Pre-symptomatic dementia)
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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Incidence of institutionalization
大体时间：Each 12 months from baseline for 5 years
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Each 12 months from baseline for 5 years
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合作者和调查者
调查人员
- 首席研究员：Geneviève CHENE, Prof、CIC-1401 EC - ISPED - CHU de Bodeaux
- 学习椅：Geneviève CHENE, Prof、CIC-1401 EC - ISPED - CHU de Bodeaux
- 研究主任：Carole DUFOUIL, Director、CIC-1401 EC - ISPED - CHU de Bodeaux
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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