- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00000460
Training Levels Comparison Trial
Training Levels Comparison (TLC) Trial in Patients With Coronary Heart Disease
Study Overview
Status
Intervention / Treatment
Detailed Description
BACKGROUND:
A vast amount of literature exists on the improvements in work capacity, reduction of risk factors, and an increased feeling of well-being among coronary heart disease patients after physical training programs. Previous observations of short-term training programs which resulted in an increase in physical working capacity have not usually shown a cardiac change. The National Exercise and Heart Disease Project did not show such changes, but the exercise level may have been inadequate. Several other studies suggested that more prolonged and intense training could result in improved cardiac function.
DESIGN NARRATIVE:
Patients were randomized to high intensity or low intensity long-term exercise groups. Compliance was strengthened by randomizing following a sequence of eligibility visits and after a test period of subject reaction to an exercise program. The primary endpoint was change in exercise ejection fraction at one year. Secondary endpoints included changes in lipid levels, body composition, blood pressure and heart rate measurements, glucose tolerance, quality of life measures, compliance, and progression of disease. Patients were classified into one of four strata based on the documented history of myocardial infarction and resting left ventricular ejection fraction. Within each stratum, patients were assigned in equal numbers to the two intensity levels of exercise intervention. All exercise prescriptions were based on exercise testing of patients maintained on their usual medical regimen including drugs. Patients underwent standardized multistage treadmill exercise testing monitored by Doppler echocardiogram at baseline, just prior to randomization and at the three month, six month, one year and two year visits. Patients participated in the structured group exercise sessions three days per week. Each exercise session was preceded by and ended with a five to fifteen minute warm-up and cool-down session. Each patient was given an exercise prescription that included a 30 minute period of walking or of walking and jogging sequences and 15 minutes of arm-leg bicycle ergometer exercise. Recruitment started in May 1987. The last patient was enrolled in March 1990.
Study Type
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Low intensity exercise
|
|
High intensity exercise
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Albert Oberman, University of Alabama at Birmingham
Publications and helpful links
General Publications
- Lee JY, Oberman A, Fletcher GF, Raczynski JM, Fletcher BJ, Nanda NC, Jensen BE. Design of the training levels comparison trial. Control Clin Trials. 1994 Feb;15(1):59-76. doi: 10.1016/0197-2456(94)90028-0.
- Kim JR, Oberman A, Fletcher GF, Lee JY. Effect of exercise intensity and frequency on lipid levels in men with coronary heart disease: Training Level Comparison Trial. Am J Cardiol. 2001 Apr 15;87(8):942-6; A3. doi: 10.1016/s0002-9149(01)01425-4.
- Jensen BE, Fletcher BJ, Rupp JC, Fletcher GF, Lee JY, Oberman A. Training level comparison study. Effect of high and low intensity exercise on ventilatory threshold in men with coronary artery disease. J Cardiopulm Rehabil. 1996 Jul-Aug;16(4):227-32. doi: 10.1097/00008483-199607000-00003.
- Lee JY, Jensen BE, Oberman A, Fletcher GF, Fletcher BJ, Raczynski JM. Adherence in the training levels comparison trial. Med Sci Sports Exerc. 1996 Jan;28(1):47-52. doi: 10.1097/00005768-199601000-00013.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 49
- R01HL037597 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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