- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00386074
Iron-fortified Whole Maize Flour Trial
April 20, 2010 updated by: Wageningen University
The Efficacy of Iron Fortified Whole Maize Flour on the Iron Status of School Children in Kenya
The purpose of this study is to assess whether NaFeEDTA and electrolytic iron improve iron status of young school children, when added as iron fortificants in whole maize flour.
Study Overview
Detailed Description
Fortification of staple foods with iron may be an effective method of addressing the problem of iron deficiency.
Questions however remain of the type of iron fortificants to use, the appropriate fortification levels and suitable food vehicles.
Cereals form attractive vehicles because they are widely consumed in parts of the world that bear a large burden of the iron deficiency problem.
They are however high in phytates and would reduce the bioavailability of commonly used iron fortificants.
Isotope studies have shown that even in the presence of phytates, iron from NaFeEDTA is relatively more bioavailable than that from other fortificant sources.
Its efficacy has however not been assessed in human trials.
Electrolytic iron, on the other hand is widely used and was legislated as the iron fortificant of choice in South Africa.
Its efficacy in a high-phytate vehicle has also not been assessed.
We have therefore undertaken to assess the efficacy of NaFeEDTA at two doses, as an iron fortificant in whole flour, and the efficacy of electrolytic iron at a dose similar to the high-dose NaFeEDTA.
The results will contribute information on the suitability of these fortificants in whole maize flour, a food commonly consumed in sub-Saharan Africa.
Study Type
Interventional
Enrollment
412
Phase
- Phase 2
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
3 years to 8 years (Child)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:Children:
- 3-8 years age (for the purposes of this study this will include children born within the period December 15th 1995- May 1st 2001).
- Whohave been resident in the area for 6 months or more.
- Enrolled in the selected schools
- Able to consume the target amount of porridge, at least 50% of the time during the run-in period
- Will be present in the study area for the entire study period (April - December 2004).
Exclusion Criteria:
- Children below 3 years and above 8 years of age (born after December 15th 1995 and before May 1st 2001).
- Children who have been resident in the area for less than 6 months at the time of recruitment.
- Children with obvious physical and mental disability.
- Severely malnourished children.
- Severely anaemic children (Hb <70g/L).
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Haemoglobin
|
Plasma Ferritin
|
Plasma Transferrin receptor
|
Secondary Outcome Measures
Outcome Measure |
---|
Iron deficiency anaemia
|
Iron deficiency
|
Anaemia
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Pauline EA Andang'o, MND, Wageningen University
- Principal Investigator: David L Mwaniki, PhD, Kenya Medical Research Institute
- Principal Investigator: Hans Verhoef, PhD, Wageningen University
- Study Director: Saskia JM Osendarp, PhD, Unilever Food and Health Institute, Vlaardingen, The Netherlands
- Study Chair: Frans J Kok, PhD, Wageningen University
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2004
Study Completion
December 1, 2004
Study Registration Dates
First Submitted
October 10, 2006
First Submitted That Met QC Criteria
October 10, 2006
First Posted (Estimate)
October 11, 2006
Study Record Updates
Last Update Posted (Estimate)
April 21, 2010
Last Update Submitted That Met QC Criteria
April 20, 2010
Last Verified
April 1, 2010
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 6107050200
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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