- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00733187
Pharmacokinetic Study To Evaluate Effect of Food and Diurnal Variation on ABT-869
A Pharmacokinetic Study to Evaluate the Effect of Food on the Oral Bioavailability and Effect of Diurnal Variation on the Pharmacokinetics of ABT-869
Study Overview
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Phase 1
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Male or female and age is ≥ 18 years.
- Must have a histologically or cytologically confirmed non-hematologic malignancy that is refractory to standard therapies or for which a standard effective therapy does not exist.
- Has measurable or evaluable disease.
- Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-2.
Must have adequate bone marrow, renal and hepatic function as follows:
- Bone Marrow: Absolute neutrophil count (ANC) ≥ 1,500/mm³; Platelets ≥ 100,000/mm³; Hemoglobin ≥ 9.0 g/dL (1.4 mmol/L)
- Renal function: serum creatinine ≤ 2.0 mg/dL (0.81 mmol/L);
- Hepatic function: AST and ALT ≤ 1.5 × ULN unless liver metastases are present, then AST and ALT ≤ 5.0 × ULN; bilirubin ≤ 1.5 mg/dL (0.026 mmol/L)
- Must have PTT ≤ 1.5 × ULN and/or INR ≤ 1.5 .
Women of childbearing potential and men must agree to use adequate contraception (one of the following listed below) prior to study entry, for the duration of study participation and up to two months following completion of therapy. Women of childbearing potential must have a negative urine pregnancy test within 7 days prior to initiation of treatment and/or post menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential.
- total abstinence from sexual intercourse (minimum one complete menstrual cycle);
- a vasectomized partner;
- hormonal contraceptives (oral, parenteral or transdermal) for at least 3 months prior to study drug administration;
- intrauterine device; * double-barrier method (condoms, contraceptive sponge, diaphragm or vaginal ring with spermicidal jellies or cream)
- Is capable of understanding and complying with parameters as outlined in the protocol and able to sign the informed consent.
- Must voluntarily sign and date each informed consent, approved by an Independent Ethics Committee (IEC)/Institutional Review Board (IRB), prior to the initiation of any screening or study-specific procedures.
Exclusion Criteria:
- Has received anti-cancer therapy within 21 days or within a period defined by 5 half lives, whichever is shorter, prior to study drug administration. Has not recovered to less than or equal to Grade 1 clinically significant adverse effects/toxicities of the previous therapy. Avastin must not have been used less than 60 days prior to receiving ABT-869.
- Has had major surgery within 21 days of Study Day 1.
- Has untreated brain or meningeal metastases. Subjects with treated, stable, asymptomatic central nervous system lesions may be considered. Subject must have had stable disease for at least 4 weeks prior to study entry.
- Has been diagnosed with hepatocellular carcinoma.
- Pregnant or breastfeeding female.
- Is receiving therapeutic anticoagulation therapy. Low dose anticoagulation for catheter prophylaxis will be permitted.
- Has a history of/or currently exhibits clinically significant cancer related events of bleeding. The subject has a recent history of (within 4 weeks of Study Day 1) or currently exhibits other clinically significant signs of bleeding.
- Has proteinuria CTC Grade > 1 at baseline as measured by a UPC ratio of > 1 and confirmed by a 24 hour urine collection. . Currently exhibits symptomatic or persistent, uncontrolled hypertension defined as diastolic blood pressure (BP) > 100 mmHg; or systolic blood pressure (BP) > 150 mmHg.
- Has a history of myocardial infarction within 6 months of Study Day 1.
- Has known autoimmune disease with renal involvement.
- Is receiving combination anti-retroviral therapy for human immunodeficiency virus (HIV).
- Clinically significant uncontrolled condition(s).
- Has active ulcerative colitis, Crohn's disease or celiac disease.
- LV Ejection Fraction < 50%.
- Current or previous enrollment in another clinical study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 1
|
0.25 mg/kg
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pharmacokinetic
Time Frame: Various timepoints
|
Blood samples for the pharmacokinetics of linifanib will be collected for each subject and each regimen (fasting, fed, AM and PM dosings).
|
Various timepoints
|
ECG Evaluation
Time Frame: Various timepoints
|
Triplicate ECG will be performed at designated timepoints.
|
Various timepoints
|
Adverse Events
Time Frame: Throught the study
|
Only treatment emergent AEs will be included.
Toxicity grade, relationship to study drug and AEs leading to discontinuation will be evaluated.
|
Throught the study
|
Lab data and vital signs
Time Frame: Various timepoints
|
Blood chemistry and hematology will be analyzed based on the regimen and dosing and overall.
24 hr ABPM will be analyzed by regimen and dosing time and overall.
|
Various timepoints
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Director: Justin Ricker, MD, AbbVie
Publications and helpful links
General Publications
- Xiong H, Chiu YL, Ricker JL, LoRusso P. Results of a phase 1, randomized study evaluating the effects of food and diurnal variation on the pharmacokinetics of linifanib. Cancer Chemother Pharmacol. 2014 Jul;74(1):55-61. doi: 10.1007/s00280-014-2475-z. Epub 2014 May 9.
- Chiu YL, Lorusso P, Hosmane B, Ricker JL, Awni W, Carlson DM. Results of a phase I, open-label, randomized, crossover study evaluating the effects of linifanib on QTc intervals in patients with solid tumors. Cancer Chemother Pharmacol. 2014 Jan;73(1):213-7. doi: 10.1007/s00280-013-2351-2. Epub 2013 Nov 16.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- M10-384
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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