- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00754975
JACTAX LD Drug Eluting Stent Trial
February 28, 2017 updated by: Boston Scientific Corporation
A Clinical Trial Comparing the Performance of the JACTAX LD DES With the TAXUS™ Libertè™ DES
Prospective, multi-center, randomized trial.
A maximum of 130 patients will be enrolled, in a 2:1 ratio to receive either the JACTAX LD stent or the TAXUS™ Libertè™ stent to evaluate the efficacy of the product.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The JACTAX Drug Eluting Stent has been designed to minimize the amount of polymer in contact with the vessel surface, thus potentially reducing the incidence of untoward side effects.
The Juxtaposed Ablumenal Coating Process is capable of exclusive coating on the ablumenal side of pre-mounted bare metal stents.
Juxtaposed Ablumenal Coating is a proprietary formulation containing a bioerodable polymer.
The combination of the Juxtaposed Ablumenal Coating Process and Juxtaposed Ablumenal Coating create a unique microstructure surface, and reduces the amount of required polymer.
Study Type
Interventional
Enrollment (Actual)
130
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Bonn, Germany
- Universitätsklinikum Bonn
-
Frankfurt, Germany
- Cardiovascular Center Sankt Katharinen
-
Hamburg, Germany
- Hamburg University Cardiovascular Center
-
Siegburg, Germany
- Helios Klinikum
-
Trier, Germany
- Krankenhaus der Barmherzigen Brüder
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
General Inclusion Criteria:
- Patient is ≥ 18 years of age
- Patient with coronary artery disease, eligible for percutaneous coronary intervention (PCI)
- Patient demonstrates a LVEF of ≥ 25%
- Patient or legal guardian understands and agrees to comply with all specified study requirements and provides written informed consent to this effect.
Angiographic Inclusion Criteria
- Target lesion is de novo native coronary artery lesion (i.e., a coronary lesion not previously treated)
- The target lesion can be treated with a maximum of one stent, with adequate coverage onto the healthy tissue, as specified in visual estimate guidelines. Maximum lesion length is 20mm.
- The reference vessel diameter is between 2.75mm and 3.5mm
- Study lesion diameter stenosis is ≥70% (visual estimate) and <100% and a TIMI flow >1.
- Study lesion has been successfully pre-dilated
- Patients enrolled for treatment may demonstrate multiple lesions in target vessel. However lesions must be covered completely by one study stent.
- Patient must have no more than two lesions requiring treatments. These lesions must be in different vessel distributions. For example, if the target lesion is in the LAD, then the non target lesion must be present in either the circumflex or RCA. The non-study lesion may not be in a branch vessel or distal to the target vessel location.
- The non target lesion must be successfully treated prior to the treatment of the target lesion. The non target lesion must be treated with a TAXUS paclitaxel eluting stent or a bare metal stainless steel stent.
General Exclusion Criteria:
- The patient has a life expectancy of less than 24 months due to another medical condition
- Patient has a history of hypersensitivity to paclitaxel or structurally related compounds
- Patient exhibits cardiogenic shock (systolic pressure <80mmHg and PCWP >20mmHg or cardiac index <1.8 liters/minute/m or intra-aortic balloon pump or intravenous inotropes are needed to maintain a systolic pressure >80mmHg) for any time within 24 hours prior to index procedure
- Patient demonstrates evidence of acute or chronic renal dysfunction (serum creatinine >2.0 mg/dl or 177 umol/l)
- Planned cardiac surgery procedure <= 9 months post index procedure
- Patient demonstrates evidence of myocardial infarction (elevated CK, CKMB or Troponin) within 72 hours prior to the index procedure and/or CK >2X local lab's ULN, unless CK-MB is < 2X ULN
- Patient exhibits acute ST segment elevation MI within 72 hours prior to the index procedure
- CVA including stroke or TIA within previous 3 months
- Patient demonstrates evidence of leukopenia
- Patient demonstrates evidence of thrombocytopenia or thrombocytosis
- Patient is contraindicated to ASA, clopidogrel or ticlopidine
- Patient is currently taking warfarin or possibility of treatment with warfarin during the following 6 months post index procedure
- Patient has been treated with paclitaxel or other chemotherapeutic agents within 12 months prior to planned index procedure
- Anticipated treatment with paclitaxel or oral rapamycin during any period in the 9 months after the index procedure
- Patient has received a drug eluting stent within 12 months prior to planned index procedure
- Previous or planned treatment with intravascular brachytherapy in target vessel
- Known allergy to stainless steel
- Male or female with known intention to procreate within 3 months after the index procedure
- Female of childbearing potential with a positive pregnancy test within 7 days before the index procedure or lactating or intends to become pregnant during the 9 months post index procedure
Angiographic Exclusion Criteria
- Evidence of probable or definite thrombus of the study vessel, based on angiography or IVUS
- Study lesion is totally occluded (TIMI flow <= 1)either at baseline or before predilatation
- Study lesion or the study vessel proximal to the study lesion is moderately or severely calcified by visual estimate
- Study lesion is ostial in location (within 3.0 mm of vessel origin)
- Study lesion involving arterial segments with highly tortuous anatomy or where lesion is located within or distal to a > 60 degree bend in the vessel
- Study lesion involves a bifurcation with a diseased (>50% stenotic) branch vessel >2.0 mm in diameter
- Left main coronary artery disease (stenosis >50%) whether protected or unprotected
- Target lesion length >20mm based on visual estimate by operator
- Target vessel diameter >3.5mm based on visual estimate by operator
- Target vessel diameter <2.75 mm based on visual estimate by operator
- Pre-treatment of the target lesion (excluding predilation) with another interventional device
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: I
JACTAX LD DES
|
Drug Eluting Stent
|
Active Comparator: II
TAXUS™ Libertè™ DES
|
Drug Eluting Stent
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
MACE rate at 9 months
Time Frame: 9 months
|
9 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Eberhard Grube, Elizabeth Hospital, Essen Germany
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2008
Primary Completion (Actual)
May 1, 2009
Study Completion (Actual)
July 1, 2010
Study Registration Dates
First Submitted
September 16, 2008
First Submitted That Met QC Criteria
September 16, 2008
First Posted (Estimate)
September 18, 2008
Study Record Updates
Last Update Posted (Actual)
March 1, 2017
Last Update Submitted That Met QC Criteria
February 28, 2017
Last Verified
February 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LBCT-H02-07
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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