Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD (PAM)

June 8, 2010 updated by: The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative AMD to Develop Exudative AMD

Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

320

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Austria
      • Vienna, Austria, 1030
        • Recruiting
        • Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery
        • Contact:
        • Sub-Investigator:
          • Ilse Krebs, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

50 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

male or female persons aged over 50 years with dry AMD

Description

Inclusion Criteria:

  • Dry MD
  • Age over 50 years

Exclusion Criteria:

  • Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole)
  • Prior vitrectomy or buckle surgery
  • Uveitis posterior, multifocal chorioiditis
  • Pathologic myopia
  • Diabetic retinopathy
  • Visualization of the macula not possible (dens cataract, vitreous haemorrhage)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Dry AMD
male or female persons aged over 50 years with dry age-related macular degeneration
Device: ultrasound
A-scan and B-scan ultrasound at baseline and month 6,12,24
Device: OCT
Volume scans of spectralis OCT at baseline and month 6,12,24

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD
Time Frame: 24 months
24 months

Secondary Outcome Measures

Outcome Measure
Time Frame
Distance acuity
Time Frame: 24 months
24 months
Age
Time Frame: 24 months
24 months
Smoking
Time Frame: 24 months
24 months
Obesity
Time Frame: 24 months
24 months
Lesion classification (AREDS)
Time Frame: 24 months
24 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery

Investigators

  • Study Chair: Susanne Binder, Prof MD, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2009

Primary Completion (Anticipated)

December 1, 2012

Study Completion (Anticipated)

December 1, 2012

Study Registration Dates

First Submitted

June 23, 2009

First Submitted That Met QC Criteria

June 23, 2009

First Posted (Estimate)

June 24, 2009

Study Record Updates

Last Update Posted (Estimate)

June 9, 2010

Last Update Submitted That Met QC Criteria

June 8, 2010

Last Verified

June 1, 2010

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 09-052-0409

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Dry Age-related Macular Degeneration

Clinical Trials on ultrasound

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Israel

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe