- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01041092
Double Blind, Placebo-controlled Study of Raloxifene for Negative Symptoms of Schizophrenia in Postmenopausal Women
Double Blind, Placebo-controlled Study of Efficacy, Safety and Tolerance of Raloxifene as an Adjuvant Treatment for Negative Symptoms of Schizophrenia in Postmenopausal Women
Primary objective: To assess the efficacy of adding raloxifene as an adjunct to antipsychotic treatment to improve negative symptoms of schizophrenia in postmenopausal women.
This is a double-blind, randomized, placebo-controlled study of raloxifene as adjuvant treatment to antipsychotic treatment. Treatment period of 12 weeks.
The primary result obtained is that women treated with 60 mg of raloxifene compared to those treated with a placebo show greater improvement in psychotic symptoms. The investigators also found improved response in some aspects of social functioning and neuropsychological functioning.
Study Overview
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
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Esplugues de Llobregat, Spain
- Fundació Sant Joan de Deu
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Diagnosis of schizophrenia (DSM-IV criteria)
- Postmenopausal patients. Postmenopause is defined as after a period of one year of spontaneous amenorrhea and a serum follicle stimulating hormone (FSH) level > 20IU/L.
- Stable doses of their current antipsychotic medication for at least a month prior to study initiation.
- Presence of significant negative symptoms (defined as one or more negative symptom score greater than 4 in the PANSS scale) (Kay 1987)
- Patients have to give written informed consent to participate in the study.
Exclusion Criteria:
- Patients with a substance abuse/dependence diagnosis in the previous six months.
- Mental retardation.
- Endocrine abnormalities, acute or chronic liver disease, impaired kidney function.
- History of thromboembolism, breast cancer, abnormal uterine bleeding, history of cerebrovascular accident.
- Patients taking hormone replacement therapy.
- Patients taking mood stabilizer medication that cannot be discontinued.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Placebo Comparator: sugar pill
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Dose of raloxifene hydrochloride will be: 60mg /day.
Patients are required to continue taking their regular medications throughout the duration of the study.
No changes in dose will be required during the study period.
Double-blind treatment will continue for 12 weeks.
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Active Comparator: raloxifene hydrochloride
Dose of raloxifene hydrochloride will be: 60mg /day.
Patients are required to continue taking their regular medications throughout the duration of the study.
No changes in dose will be required during the study period.
Double-blind treatment will continue for 12 weeks.
|
Dose of raloxifene hydrochloride will be: 60mg /day.
Patients are required to continue taking their regular medications throughout the duration of the study.
No changes in dose will be required during the study period.
Double-blind treatment will continue for 12 weeks.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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The primary efficacy end-point will be the change in the score of the PANSS negative subscale from baseline to follow-up assessment.
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Secondary Outcome Measures
Outcome Measure |
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Patients social and neuropsychological functioning will be evaluated, comparing baseline ratings to end-point.
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Collaborators and Investigators
Sponsor
Publications and helpful links
General Publications
- Huerta-Ramos E, Iniesta R, Ochoa S, Cobo J, Miquel E, Roca M, Serrano-Blanco A, Teba F, Usall J. Effects of raloxifene on cognition in postmenopausal women with schizophrenia: a double-blind, randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2014 Feb;24(2):223-31. doi: 10.1016/j.euroneuro.2013.11.012. Epub 2013 Dec 1. Erratum In: Eur Neuropsychopharmacol. 2015 Jun;25(6):966.
- Usall J, Huerta-Ramos E, Iniesta R, Cobo J, Araya S, Roca M, Serrano-Blanco A, Teba F, Ochoa S. Raloxifene as an adjunctive treatment for postmenopausal women with schizophrenia: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry. 2011 Nov;72(11):1552-7. doi: 10.4088/JCP.10m06610. Epub 2011 Aug 23.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Mental Disorders
- Schizophrenia Spectrum and Other Psychotic Disorders
- Schizophrenia
- Physiological Effects of Drugs
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormone Antagonists
- Bone Density Conservation Agents
- Estrogen Antagonists
- Selective Estrogen Receptor Modulators
- Estrogen Receptor Modulators
- Raloxifene Hydrochloride
Other Study ID Numbers
- 04T-504
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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