- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01418560
Renal Sympathetic Modification in Patients With Chronic Renal Failure
March 18, 2019 updated by: Yuehui Yin, The Second Affiliated Hospital of Chongqing Medical University
The purpose of this study is to observe the incident of uremia and dialysis requirement after renal sympathetic modification using THERMOCOOL® catheter in patients with chronic renal failure, and evaluate safety and efficacy of the intervention.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Chronic renal failure is serial clinical manifestations because of kidney damage.
Previous studies found sympathetic nerves over activity in chronic renal failure patients.
Traditional therapies included medications and dialysis replacement therapy need to spend much money.
Renal ablation for sympathetic modification is a new method which is proved to be effective in decreasing sympathetic nerves activity.
We assume that modifying renal sympathetic activity by ablation is effective and safe in treatment of chronic renal failure.
This trial is going to recruit 200 patients (Ablation group VS Control group = 1:1) with a follow-up duration of 3 years.
Patients in ablation group will receive additional necessary medications besides expectant intervention, and patients in control group will receive appropriate medications only.
We aim to observe the effect of serum creatinine, creatinine clearance rate, glomerular filtration rate, urine microalbumin, urine microalbumin/creatinine, and composite cardio cerebrovascular events after renal sympathetic modification using THERMOCOOL® catheter, and evaluate safety and efficacy of the intervention.
Study Type
Interventional
Enrollment (Anticipated)
200
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Chongqing
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Chongqing, Chongqing, China, 400010
- Recruiting
- 2ndChongqingMU
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- ≥ 18 years old, and ≤ 75 years old of age
- at least three months history of definite kidney damage
- renal function of serum creatinine of < 354umol/L, and/or creatinine clearance rate of ≥ 30ml/min, and/or estimated glomerular filtration rate of ≥ 45ml/min for recent 2-3 times evaluation. Besides, the value of creatinine clearance rate fluctuated no more than 30% in recent three months, and 15% in the following two weeks.
- urine microalbumin, and/or urine microalbumin/creatinine is abnormal, and/or quantity of 24 hrs urine protein suggests kidney damage.
- is competent and willing to provide written, informed consent to participate in this clinical study
Exclusion Criteria:
- congenital renal diseases cause to chronic renal damage
- estimated glomerular filtration rate (eGFR) of < 45mL/min
- taking medicine of glucocorticosteroids, non-steroid anti-inflammatory drugs (NSAIDs), or cytotoxic drugs at present
- value of 24 hrs urine protein is of > 10g at least once in recent three months, or serum albumin of < 25g/L
- has the history of renal restenosis or renal stents implantation
- has experienced AMI (old myocardial infarction is not excluded), unstable angina pectoris, cerebrovascular accidents, and alimentary tract hemorrhage within 3 months
- carcinoma patients
- patients with sick sinus syndrome
- pregnant women
- mental disorders
- patients that have allergy to contrast agent
- patients that do not go with follow-up
- others such as researcher considers it is not appropriate to be included into the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NON_RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: renal sympathetic modification
Renal artery ablation to modify sympathetic activity in patients with chronic renal failure.
|
Device: THERMOCOOL® Catheter Renal sympathetic modification with a catheter-based procedure
Other Names:
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NO_INTERVENTION: Absolute medicine therapy
Maintenance of anti-renal failure medications only
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
the incident of uremia and dialysis requirement
Time Frame: three years
|
three years
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
serum creatinine increases into multiples in 1 month follow-up
Time Frame: three years
|
three years
|
effect of urine microalbumin, urine microalbumin/creatinine, serum creatinine, or 24 hrs urine protein value
Time Frame: three years
|
three years
|
incidence of composite cardiovascular events
Time Frame: three years
|
three years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
August 1, 2011
Primary Completion (ANTICIPATED)
December 1, 2019
Study Completion (ANTICIPATED)
June 1, 2020
Study Registration Dates
First Submitted
August 15, 2011
First Submitted That Met QC Criteria
August 16, 2011
First Posted (ESTIMATE)
August 17, 2011
Study Record Updates
Last Update Posted (ACTUAL)
March 19, 2019
Last Update Submitted That Met QC Criteria
March 18, 2019
Last Verified
March 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SWAN-RF
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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